Business Wire

Abzena and Lipum AB Sign Integrated CMC Agreement to Produce a Novel Biologic for Autoimmune Inflammatory Diseases

Jaa

Abzena, the global biologics gene to GMP partner research organization, announced it has signed an agreement to support an integrated CMC program with Lipum, a company developing treatments for chronic inflammatory diseases.

Abzena will support Lipum’s anti-BSSL antibody IND program to help develop a novel therapeutic option for autoimmune inflammatory diseases, including juvenile idiopathic arthritis. The 18-month program includes: development of a research cell bank using Abzena’s proprietary cell line and ambr® 15 automated high throughput bioreactors, generation of master cell banks, scale up using an ambr® 250 during process development, followed by cGMP manufacturing in Sartorius 500 L single use stirred tank bioreactors for clinical material. The work will take place at Abzena’s sites in Cambridge, UK and San Diego, USA.

Jonathan Goldman, CEO of Abzena, said:

“Autoimmune inflammatory diseases such as juvenile idiopathic arthritis represent significant unmet medical need. We are delighted to leverage our expertise and integrated capabilities to accelerate the timeline to first in man evaluation. Lipum is an innovative science driven organization with visionary leadership and I am personally very excited about the potential for anti-BSSL therapeutics to transform patient outcomes.”

Einar Pontén, CEO of Lipum, said:

“A lead drug candidate has been selected, so this is an exciting step in Lipum's development. Our antibody is directed towards a novel target protein and will meet a significant medical need. It is essential to have such a competent partner as Abzena. We have a very positive impression of both their resources and staff. It will be stimulating to work with them.”

About anti-BSSL

BSSL (bile salt-stimulated lipase) is a novel target for treatment of autoimmune inflammatory diseases which acts by promoting recruitment of inflammatory and immune cells to the site of acute inflammation, which in the normal case helps to control the inflammation. However, when an inflammation becomes “chronic” the effect of BSSL instead contributes to sustaining the inflammation. The anti-BSSL antibody being developed aims to inhibit this inflammatory process. The efficacy has been demonstrated in several different animal inflammation models. Lipum is evaluating the possibility to address Juvenile Idiopathic Arthritis (JIA) as the first indication for the product.

Lipum has received funding from the European Commission, Executive Agency for Small and Medium-Sized Enterprises (EASME), under the EU Framework Programme for Research and Technological Development (Horizon 2020) for the purpose of developing its BSSL antibody for treatment of various autoimmune diseases.

About Abzena

Abzena provides the most complete set of solutions in integrated early discovery to mid-phase biotherapeutic and ADC drug development services in the pharmaceutical industry. The company maintains resources around the world, with facilities in the US and UK. Abzena is partnered with Welsh, Carson, Anderson & Stowe, one of the world’s leading private equity investors. For more information, please see www.abzena.com.

About Lipum

Lipum is a Swedish company aiming for better quality of life for the millions suffering from chronic inflammatory diseases, including children. They intend to increase their quality of life and decrease the considerable health care and societal costs. Lipum is currently developing an alternative to current biological treatments for patients not responding, or responding transiently to current TNFα inhibitors. For more information, visit www.lipum.se.

Contact information

Abzena
Joseph Reeds
joseph.reeds@abzena.com
+44 1223 903367

Lipum
Dr Einar Pontén
einar.ponten@lipum.se
+46 90 3403430

Tietoja julkaisijasta

For more than 50 years, Business Wire has been the global leader in press release distribution and regulatory disclosure.

Tilaa tiedotteet sähköpostiisi

Haluatko tietää asioista ensimmäisten joukossa? Kun tilaat mediatiedotteemme, saat ne sähköpostiisi välittömästi julkaisuhetkellä. Tilauksen voit halutessasi perua milloin tahansa.

Lue lisää julkaisijalta Business Wire

Andersen Global Expands Africa Presence; Signs Collaboration Agreement in Economic Hub of South Africa18.4.2019 16:30:00 EESTTiedote

Andersen Global is excited to announce the addition of its first collaborating firm in South Africa. Tabacks Attorneys and Corporate Law Advisors, headquartered in Johannesburg, South Africa, has signed a Collaboration Agreement with Andersen Global, an international association of member and collaborating firms. South Africa marks the tenth country in Africa in which Andersen Global has a presence. Led by Chairman David Woodhouse, Tabacks has a team of 27 lawyers who offer legal assistance and commercial advice to a diverse clientele in construction, manufacturing, energy, mining, explosives, retail, hospitality, logistics, pharmaceutical, property and banking industries. The firm is considered a leading law firm in South Africa, and its practice areas include competition law, commercial law, mining, employment law, environmental health & safety law, tax and litigation. “The global economy is rapidly changing, which brings unique challenges to corporate and commercial law,” said David

Amazon and Google Announce Official YouTube Apps to Launch on Fire TV; Prime Video App Coming to Chromecast and Android TV18.4.2019 16:00:00 EESTTiedote

Today, Amazon (NASDAQ: AMZN) and Google (NASDAQ: GOOGL) announced that in the coming months, the two companies will launch the official YouTube app on Amazon Fire TV devices and Fire TV Edition smart TVs, as well as the Prime Video app for streaming to Chromecast and Chromecast built-in devices. In addition, Prime Video will be broadly available across Android TV device partners, and the YouTube TV and YouTube Kids apps will also come to Fire TV later this year. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20190418005212/en/ “We are excited to work with Amazon to launch the official YouTube apps on Fire TV devices worldwide,” said Heather Rivera, Global Head of Product Partnerships at YouTube. “Bringing our flagship YouTube experience to Amazon Fire TV gives our users even more ways to watch the videos and creators they love.” “We’re excited to bring the Prime Video app to Chromecast and Android TV devices, and to give our c

KCI Files Registration Statement for Proposed Initial Public Offering18.4.2019 16:00:00 EESTTiedote

Acelity announced today that its affiliate, KCI Holdings, Inc. (“KCI”), filed a registration statement on Form S-1 with the U.S. Securities and Exchange Commission (“SEC”), relating to a proposed initial public offering of KCI’s common stock. Prior to the effectiveness of the registration statement, there will be a restructuring as a result of which KCI will become the holding company of the businesses currently conducted by Acelity L.P. Inc. and its subsidiaries. The number of shares to be offered and the price range for the proposed offering have not yet been determined. J.P. Morgan, Goldman Sachs & Co. LLC and BofA Merrill Lynch are acting as joint book-running managers for the proposed offering. The offering will be made only by means of a prospectus. When available, a copy of the preliminary prospectus related to the offering may be obtained from: J.P. Morgan, Attention: Prospectus Department c/o Broadridge Financial Solutions, 1155 Long Island Avenue, Edgewood, NY 11717, via tele

Strasbourg Approves the Covered Bond Legislative Package: a Milestone for the Future of the Industry and the Capital Markets Union18.4.2019 15:06:00 EESTTiedote

Following the trilogue negotiations with the Council and the European Commission on the proposal for a Covered Bond Legislative Package, the European Parliament’s Plenary adopted today in Strasbourg the text which had been approved by the Council (Coreper) on 20 March and then by the European Parliament’s Economic and Monetary Affairs (ECON) Committee on 1 April 2019. In this context, the European Mortgage Federation - European Covered Bond Council (EMF-ECBC ) welcomes the adoption of the Covered Bond Legislative Package, which aims at completing the Capital Markets Union (CMU) in Europe. The Package provides a basis for enhanced harmonisation of the European covered bond market, in line with the objectives of the CMU, reinforcing a European common qualitative benchmark for international investors and respecting well-functioning traditional markets. It moreover paves the way for the smooth introduction of this asset class in newer and emerging covered bond markets in the Union, such as

Schlumberger Announces First-Quarter 2019 Results18.4.2019 14:00:00 EESTTiedote

Schlumberger Limited (NYSE: SLB) today reported results for the first quarter of 2019. (Stated in millions, except per share amounts) Three Months Ended Change Mar. 31, 2019 Dec. 31, 2018 Mar. 31, 2018 Sequential Year-on-year Revenue $7,879 $8,180 $7,829 -4% 1% Pretax operating income $908 $967 $974 -6% -7% Pretax operating margin 11.5 % 11.8 % 12.4 % -30 bps -91 bps Net income - GAAP basis $421 $538 $525 -22% -20% Net income, excluding charges & credits* $421 $498 $525 -15% -20% Diluted EPS - GAAP basis $0.30 $0.39 $0.38 -23% -21% Diluted EPS, excluding charges & credits* $0.30 $0.36 $0.38 -17% -21% North America revenue $2,738 $2,820 $2,835 -3% -3% International revenue $5,037 $5,283 $4,883 -5% 3% North America revenue, excluding Cameron $2,178 $2,265 $2,285 -4% -5% International revenue, excluding Cameron $4,469 $4,581 $4,147 -2% 8% *These are non-GAAP financial measures. See section titled "Charges & Credits" for details. Schlumberger Chairman and CEO Paal Kibsgaard commented, “Fir

IDEMIA Provides NOS with eSIM Management Solutions18.4.2019 13:49:00 EESTTiedote

At the occasion of the launch of the first ever eSIM (embedded SIM) service on the Portuguese market, NOS today introduces with IDEMIA an eSIM subscription management commercial service for the consumer market, based on a physical voucher approach and future evolution towards a digital voucher. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20190418005321/en/ (Photo: IDEMIA) As a major actor in the telecom field, IDEMIA is at the forefront of the digital revolution and is committed to bringing protected and convenient experiences to mobile operator customers. IDEMIA will be providing NOS its eSIM management solutions that will provide instant digital connectivity that allows users to connect any electronic device straight out-of-the-box and link multiple devices to the same mobile subscription. eSIM offers a streamlined user experience when it comes to managing cellular connectivity for Enterprises. According to ABI Research,

Uutishuoneessa voit lukea tiedotteitamme ja muuta julkaisemaamme materiaalia. Löydät sieltä niin yhteyshenkilöidemme tiedot kuin vapaasti julkaistavissa olevia kuvia ja videoita. Uutishuoneessa voit nähdä myös sosiaalisen median sisältöjä. Kaikki STT Infossa julkaistu materiaali on vapaasti median käytettävissä.

Tutustu uutishuoneeseemme