COVID-19 Vaccine Adjuvant Potentials of Nichi Glucan Dietary Supplement From Japan
ß- glucan produced by AFO-202 strain of black yeast Aureobasidium Pullulans (Nichi Glucan), having immune enhancement potentials through all major pathways, has been recommended worth clinical studies for validation as a vaccine adjuvant in COVID-19 (https://doi.org/10.1080/21645515.2021.1880210). Pathogens entering through nasal or oral route are tackled by mucosal immunity and antibodies in saliva and once inside the body by innate and adaptive immune systems and the trained immunity (TRIM). Nichi Glucan may have beneficial effects through all the above, describes the scientific publication journal associated with the International Society of Vaccines.
This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20210303005365/en/
Nichi Glucan is reported to have potentials to act through all the four pathways of immune system viz., Mucosal immunity, Adaptive immunity, Innate immunity and Trained immunity. Research on novel beta-glucans is essential to help find ways to boost human immunity, keeping in mind the present Covid-19, mutating variants and future pandemics. (Graphic: Business Wire)
Nichi Glucan as vaccine adjuvant: Adjuvants are agents that supplement vaccines by enhancing or stabilizing them. Nichi glucan with immunomodulating potential is considered more advantageous as it’s vaccine adjuvant efficacy against Avian influenza (H5N1, H5N2) have been reported (https://pubmed.ncbi.nlm.nih.gov/21532325/), has a safety track record of consumption as a food supplement in Japan since 1996 and beneficial effects in general health documented in human studies described below.
- Immune enhancement and balancing benefits in studies in cancer patients, young adults and elderly healthy volunteers (https://doi.org/10.3389/fimmu.2020.01548)
- Coagulopathy related to COVID-19, could be tackled in populations at high-risk for blood clotting disorders; Thrombosis (https://doi.org/10.1186/s12959-020-00239-6)
- Balancing of blood sugar and cholesterol potential may reduce mortality in SARS-CoV-2 patients; Journal of Diabetes & Metabolic Disorders (https://doi.org/10.1007/s40200-020-00664-4).
- Beta glucans in Trained immunity is reported to be more robust as they act on bone marrow which produces blood components and immune cells.
Earlier, associates of GN Corporation were granted a patent on Influenza Neutralizing Antibody to identify vulnerable population for vaccine administration, accomplished in collaboration with Dr. Yoshikazu Kurosawa, a monoclonal antibody researcher, recognized by Prof. Susumu Tonegawa in his Nobel prize for medicine – lecture in 1987 (https://www.nobelprize.org/uploads/2018/06/tonegawa-lecture.pdf).
Human beings lack an ability to advantageously mutate their DNA or RNA unlike viruses; therefore, left with the only option of boosting their immune system for protection from evolving new pathogens and mutating viruses. Fungi having contributed significantly to human health yielding antimicrobial agents such as Penicillin and many anti-cancer agents, further research on this black yeast looks very promising said Dr. Gene Kurosawa, a co-author. Clinical studies on prebiotic potentials of Nichi Glucan to solve gut dysbiosis by balancing gut microbiota are underway.
Samuel JK Abraham
About Business Wire
For more than 50 years, Business Wire has been the global leader in press release distribution and regulatory disclosure.
Subscribe to releases from Business Wire
Subscribe to all the latest releases from Business Wire by registering your e-mail address below. You can unsubscribe at any time.
Latest releases from Business Wire
The Federation of Royal Colleges of Physicians Approves UpToDate Clinical Decision Support for CPD20.4.2021 16:30:00 EEST | Press release
UpToDate, the clinical decision support tool from Wolters Kluwer, Health has been approved by the Federation of the Royal Colleges of Physicians of the United Kingdom as a continuing professional development (CPD) activity. The organization is a collaboration between the Royal College of Physicians of London, Royal College of Physicians of Edinburgh, and Royal College of Physicians and Surgeons of Glasgow. The colleges have more than 50,000 members among them worldwide. The approval of UpToDate comes following new guidelines introduced by the Federation that recognize the use of online resources with current medical content (e-libraries) as CPD. Earning CPD while caring for patients Members will now be able to earn and track credits eligible for continuing professional development while using UpToDate to research clinical questions at the point of care. CPD credits are earned from UpToDate by consulting information relevant to a specific clinical question, thus broadening clinical know
MSCI Calls on Capital to Lead the Net-Zero Revolution20.4.2021 16:21:00 EEST | Press release
Addressing climate change will require the largest reconstruction of the global economy since the Industrial Revolution, according to a report published today by MSCI Inc. (NYSE: MSCI), a leading provider of critical decision support tools and services for the global investment community. ‘The Role of Capital in the Net-Zero Revolution’ highlights how capital markets participants must be a powerful and positive force to urgently drive the systemic transformation needed to avert climate catastrophe. This call to action identifies specific steps that companies as well as owners and managers of capital must take to drive the achievement of a net-zero economy by 2050. Analysis by MSCI of its All Country World Investable Markets Index (MSCI ACWI IMI) - a measure of approximately 9,000 publicly listed companies across 50 developed and emerging markets with a market value of over USD 70 trillion1 – revealed those companies annually emit an estimated 11.2 gigatons of carbon dioxide equivalent
PPG Reports Increased Sales of Sustainably Advantaged Products, Continued Progress on Sustainability Goals20.4.2021 16:04:00 EEST | Press release
PPG (NYSE:PPG) today launched its 2020 Sustainability Report, highlighting the company’s strong, continued progress against key environmental, social and governance (ESG) areas. The report is available at sustainability.ppg.com. “Our unwavering commitment to ‘protect and beautify the world’ guides our more than 46,000 employees to further advance our sustainability progress each day,” said Michael H. McGarry, PPG chairman and chief executive officer. “We continue to innovate, invest and develop sustainably advantaged products and processes that our customers and other stakeholders count on to create a more sustainable future. As highlighted in our latest Sustainability Report, we have made significant progress within our many ESG-related initiatives, and we continue to drive our ambitious targets forward.” Throughout last year, PPG improved the sustainability of its products, processes and operations, decreasing its overall global environmental footprint. Achievements included: 35% of
Magnitude Introduces Cloud-Scale Business Insights for ERP Systems20.4.2021 16:00:00 EEST | Press release
Magnitude Software, provider of continuous intelligence for the data-driven enterprise, today announced the release of Magnitude Angles Cloud, a cloud-based version of the company’s Angles process analytics solution. Angles Cloud greatly accelerates the delivery of powerful business insights from SAP and Oracle ERP systems directly to operational leaders in finance, supply chain, manufacturing and distribution, enabling them to make faster, more effective business decisions. Traditional business intelligence reporting requires custom development by teams of data scientists, skilled in translating the complex data schema of ERP systems, to build reports consumable by business users. Magnitude Angles provides a context-rich business data model that abstracts this complexity and includes thousands of pre-configured templates and reports to put operational analytics in the hands of business users. By eliminating the need for time-consuming custom development to provide near real-time busin
Tradeweb Joins Climate Bonds Initiative Partners Program20.4.2021 16:00:00 EEST | Press release
Tradeweb Markets Inc. (Nasdaq: TW), a leading, global operator of electronic marketplaces for rates, credit, equities and money markets, today announced it has joined the Climate Bonds Initiative’s Partners Program, a global movement seeking to mobilise bond markets for climate change solutions. Climate Bonds Initiative is an international, investor-focused not-for-profit organisation, promoting investment in projects and assets necessary for a rapid transition to a low carbon and climate resilient economy. The Climate Bonds Standard and Certification Scheme is a labelling scheme for bonds, loans and other debt instruments. The rigorous scientific criteria ensure consistency with the goals of the Paris Climate Agreement. The Scheme is used globally by bond issuers, governments, investors and the financial markets to prioritize investments, which genuinely contribute to addressing climate change. The Climate Bonds Initiative has been tracking the green labelled market since 2009. By par
Introducing the HARMAN Ignite Store Developers Portal: Dedicated Automotive Hub for Android Developers20.4.2021 16:00:00 EEST | Press release
HARMAN, a wholly-owned subsidiary of Samsung Electronics Co., Ltd. focused on connected technologies for automotive, consumer and enterprise markets, today announced the introduction of the HARMAN Ignite Store Developers Portal – a developer hub dedicated to the Android Automotive developer community. Through the Developers Portal, those developing to the Android Automotive open operating system can deploy automotive apps – which OEMs can then easily scale and manage to drive new digital touchpoints with their customers through the HARMAN Ignite Store. As the cloud continues to drive both disruption and opportunity across mobility, the Ignite Store Developers Portal applies HARMAN’s decades of expertise across automotive and technology segments to accelerate the creation, deployment, and consumer adoption of in-vehicle apps. Android developers now can benefit from toolkits, technical documentation, access to APIs, and HARMAN’s existing network of OEMs, while automotive manufacturers ca
BIO KOREA 2021 International Convention Is Ready - Showing What Makes Korea’s Bio-health Market at Record High20.4.2021 15:00:00 EEST | Press release
The 16th edition of BIO KOREA, the reference B2B event for global biotech and health industry professionals interested in opportunities in the Asian region, will be held online from 9th to 21st June 2021 with an onsite show at COEX in Seoul from 9th to 11th June. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20210420005089/en/ In the global market, the bio-health industry is notching an annual average growth rate of 4 percent, higher than the shipbuilding and auto-making industry at 2.9 percent and at 1.5 percent, respectively. Especially, the Korean bio-health industry shows remarkable growth – its bio-health industry set a new milestone in outbound shipments with a 50 percent jump last year, led by robust demand for COVID-19 test kits and biosimilar products. With the record high export figures, the bio-health sector joins the ranks of the mainstay export industry for the first time in its history. The game-changers of the
In our pressroom you can read all our latest releases, find our press contacts, images, documents and other relevant information about us.Visit our pressroom