Global survey reveals that physicians need more information to assess the impact of treatment sequencing on patient survival in EGFR mutation-positive NSCLC
Results from a new global survey revealed that more than one-third (36%) of the 310 physicians surveyed do not think they have sufficient information required to make informed decisions on how to sequence treatments for patients with epidermal growth factor receptor mutation-positive (EGFR M+) non-small cell lung cancer (NSCLC). The survey results will be presented today as a late-breaking abstract (P3.01-108) at the 2018 World Conference on Lung Cancer (WCLC) in Toronto, Canada.
The two most important treatment goals identified by those surveyed were increasing overall survival (OS) (77%), followed by quality of life (QoL) (69%), irrespective of the line of treatment.
Findings show that more than half (55%) of physicians strongly preferred a treatment sequence that offers patients the maximum time on targeted treatments. Furthermore, physicians reported that there is a strong need for information on potential treatment resistance mutations before changing their current treatment practice.
More information to make informed treatment decisions was needed depending on whether physicians preferred:
- a first-line targeted treatment with the longest progression-free survival (PFS), or
- a first-line targeted treatment which offers the potential to use a different targeted therapy in second-line.
43% of those who preferred a treatment offering the longest PFS said they needed more information to make an informed treatment decision on the sequencing of targeted treatments compared to 23% of those who favour a first-line targeted treatment which offers the potential to use a targeted therapy in second-line.
Prof. Dr. Thomas Wehler PhD, Evangelisches Krankenhaus, Hamm, Germany, commented, “The results of this study show that physicians are unclear as to the best way to sequence targeted treatments in order to increase survival times, which is the main goal when selecting treatments for patients with EGFR mutation-positive NSCLC. More information and guidance around the impact of treatment sequencing on overall survival is required to support physicians when making treatment decisions.”
Dr. Victoria Zazulina, Global Head of Solid Tumour Oncology, Medicine at Boehringer Ingelheim, commented, “The availability of more treatment options means physicians now have the opportunity to sequence targeted treatments for EGFR mutation-positive NSCLC patients and consider the bigger picture from diagnosis. We undertook this research to learn what considerations guide physicians’ decisions to sequence targeted therapies, and this study unveiled the gap in clinical data that could clearly inform such decisions. Consequently, we embarked on a real-world evidence study evaluating the EGFR tyrosine kinase inhibitor (TKI) treatment sequence in patients with EGFR-mutant NSCLC, and are looking forward to sharing the outcomes with the physician community later this year.”
About the survey
The Boehringer Ingelheim-sponsored survey evaluated 310 physicians (Oncologists, Pulmonologists, Respiratory Surgeons and Internal Respiratory Specialists) across four countries (China: 70, Germany: 70, Japan: 70 and USA: 100). The survey aimed to assess current attitudes towards decision making for TKI sequencing to determine what matters most when selecting a treatment and what challenges physicians face when initiating targeted treatment in EGFR M+ NSCLC patients.
Please click on the link for ‘Notes to Editors’ and ‘References’: http://www.boehringer-ingelheim.com/press-release/nsclctreatmentsequencingsurvey
For more information, please visit: www.boehringer-ingelheim.com
Media + PR
Phone: +49 6132 – 77 184867
Mobile: +49 (151) 14368601
Fax: +49 6132 – 77 6601
For more than 50 years, Business Wire has been the global leader in press release distribution and regulatory disclosure.
Tilaa tiedotteet sähköpostiisi
Haluatko tietää asioista ensimmäisten joukossa? Kun tilaat mediatiedotteemme, saat ne sähköpostiisi välittömästi julkaisuhetkellä. Tilauksen voit halutessasi perua milloin tahansa.
Lue lisää julkaisijalta Business Wire
Knopp Biosciences to Present at the Piper Jaffray 30th Annual Healthcare Conference21.11.2018 14:00 | Tiedote
Knopp Biosciences LLC, a privately held drug discovery and development company focused on delivering breakthrough treatments for inflammatory and neurological diseases of high unmet need, today announced that management will present at the Piper Jaffray 30th Annual Healthcare Conference to be held in New York, NY on November 27-29. Michael Bozik, M.D., President and CEO of Knopp Biosciences, is scheduled to present on Tuesday, November 27th at 12:50 p.m. Eastern Time. ABOUT KNOPP BIOSCIENCES LLC Knopp Biosciences is a privately held drug discovery and development company focused on delivering breakthrough treatments for inflammatory and neurological diseases of high unmet need. Knopp’s clinical-stage small molecule, dexpramipexole, is entering Phase 3 clinical studies in hypereosinophilic syndrome and Phase 2 clinical studies in eosinophilic asthma. Knopp’s preclinical Kv7 platform is directed to small molecule treatments for neonatal epileptic encephalopathy, other rare epilepsies, ti
REPLY: Syskoplan Reply Awarded with the SAP Quality Award in the Innovation Category21.11.2018 12:00 | Tiedote
Syskoplan Reply, the SAP technology specialist within the Reply Group, has been awarded with the SAP Quality Award from SAP in the Innovation category for a project for the SEA Group. The award honors the latest SAP solutions and it is presented annually at the SAP NOW event. Syskoplan Reply receives the renowned award for the fifth time in a row. The gold award winning project is an innovative SAP Hybris Marketing solution for SEA from Syskoplan Reply. The SEA Group manages both Milan Linate and Milan Malpensa airports and provides all services and related activities. The project consists of implementing SAP Hybris Marketing to design, create and monitor marketing initiatives. The aim is to increase the customer experience of passengers at Milan Malpensa Airport and make their stay a special experience. The cross-departmental, effective marketing campaign is based on the concept of gamification: in the multi-channel campaign, passengers can participate in a treasure hunt "Hashtag Hunt
Clientron to exhibit its embedded computing innovations at SPS IPC Drives 201821.11.2018 12:00 | Tiedote
Clientron Corp., a world-leading supplier of embedded systems, will introduce its intelligent embedded solutions including single board computers, embedded box PC, and industrial panel PC at SPS IPC Drives 2018, taking place at the Exhibition Centre Nuremberg (No.8-512, Hall 8) from 27 to 29 November in Nuremberg, Germany. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20181121005002/en/ Clientron to exhibit its brand new intelligent embedded systems at SPS IPC Drives 2018 (Photo: Business Wire) The SPS IPC Drives is the leading trade fair for electronic automation solutions. At the show, Clientron will proud to illustrate its embedded computing solutions for factory automation and food industry applications. The advantages of Clientron’s products are designed for high quality, durability, flexibility and maximum compatibility to facilitate the business transformation towards Industry 4.0. During the show, Clientron will intro
GSMA Launches New Industry-Wide Initiative to Support Development of Operator Edge Cloud AR/VR21.11.2018 12:00 | Tiedote
The GSMA today announced the launch of a new industry-wide initiative called The GSMA Cloud AR/VR Forum that will focus on the development of cloud virtual reality (VR) and augmented reality (AR) technology. The programme which was unveiled at Huawei’s 9th Global Mobile Broadband Forum in London, is backed by mobile operators including China Mobile, China Telecom, China Unicom, Deutsche Telekom, KDDI, KT Corp., NTT DOCOMO, SK Telecom, Telefónica, Telenor, TIM, Turkcell and Vodafone, as well as other industry partners including Huawei and HTC. The programme aims to encourage all parties to collaborate on accelerating the delivery and deployment of 5G cloud-based AR/VR services. “Both VR and AR are disruptive forms of immersive multimedia that, combined with operator edge cloud and 5G connectivity, will transform the cost structures of the enterprise and entertainment fields,” commented Alex Sinclair, Chief Technology Officer, GSMA. “Mobile operators will play a key role in its developme
Wireless charging makes a world’s first debut on South Western Railway trains in the UK.21.11.2018 12:00 | Tiedote
Baker Bellfield, one of the UK’s leading suppliers of commercial interior solutions for the rail sector, and Aircharge, global leader in wireless charging solutions for contract use, have announced today the launch of the world’s first fully rail compliant inductive phone wireless charging system. On-train wireless charging will debut on South Western Railway’s (SWR) refurbished and reconfigured class 444 Siemens Desiro five-car EMUs on the London Waterloo – Southampton – Bournmouth – Weymouth route from November 2018. When the refurbishment programme is completed, all 172 of SWR Desiro class trains will have this new feature. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20181121005180/en/ The Aircharge - Baker Bellfield mobile phone wireless charging solution for trains (Photo: Business Wire) With mobile devices becoming the best travel companions for personal and business purposes, including the use of mobile check-in appl
iCard and myPOS Enable JCB Contactless Acceptance in Europe21.11.2018 11:35 | Tiedote
JCB International, Co., Ltd. (JCBI), the international operations subsidiary of JCB Co., announced the rollout of JCB Contactless* acceptance with iCard, a licenced electronic money provider and myPOS Europe Ltd, an FCA Authorised (London) electronic money institution. iCard is the acquirer of the transactions behind the myPOS Service and the combined deal facilitates the acceptance of JCB’s branded contactless payment solutions, JCB Contactless, with merchants across Europe. JCB cardmembers will be able to pay for goods and services at merchants acquiring payments using myPOS contactless-enabled payment terminals with a tap of their card or smartphone. This is an important milestone for JCB´s global contactless reach as the company drives acceptance coverage across the European Economic Area (EEA) and Switzerland for its 117 million JCB cardmembers. Mr. Tsuyoshi Notani, Managing Director, JCB International (Europe) Ltd., said: “This is a significant new partnership for JCB’s advanced
Uutishuoneessa voit lukea tiedotteitamme ja muuta julkaisemaamme materiaalia. Löydät sieltä niin yhteyshenkilöidemme tiedot kuin vapaasti julkaistavissa olevia kuvia ja videoita. Uutishuoneessa voit nähdä myös sosiaalisen median sisältöjä. Kaikki STT Infossa julkaistu materiaali on vapaasti median käytettävissä.Tutustu uutishuoneeseemme