Heartseed raises 2 billion JPY in series D funding to accelerate development of iPSC-derived stem cell therapy for heart failure
Heartseed (Heartseed Inc.), a Tokyo-based biotechnology company developing iPSC-derived cardiomyocytes for heart failure (HF), today announced it has raised 2 billion JPY at Series D round, bringing its total financial backing to 10.2 billion JPY (approx. $74 million) since it was founded in 2015.
New investors are Japan Co-Invest IV Limited Partnership (GP: Sumitomo Mitsui Trust Investment), Arcus South East Asia, Atsushi Sakano (Partner of Aspex Management), Koei Tecmo Capital, Nikon-SBI Innovation Fund, etc. Among the existing investors, SMBC Venture Capital, Private Equity Co-Invest II Limited Partnership (GP: Sumitomo Mitsui Trust Investment), UTokyo Innovation Platform, Medical Incubator Japan, Keio Innovation Initiative (KII), etc. participated this round.
Heartseed plans to use the new funds to complete the Phase 1/2 clinical trial of our lead asset, HS-001 for HF in Japan, as well as to establish an organization for its launch. In addition, Heartseed will also examine a less invasive administration such as transendocardial injection using a catheter for global development by Novo Nordisk.
“Heartseed achieved the first human dosing of HS-001 in December 2022, and initial safety and early sings of efficacy are being confirmed.” said Keiichi Fukuda, co-founder and CEO at Heartseed. “The commitment from both new and existing investors in this round is a strong validation of our technology and strategic vision. With their support, we look forward to accelerating our development to deliver potentially curative therapy for heart failure across the globe.”
About HS-001 and LAPiS Study
HS-001, is allogeneic iPSC-derived, highly purified ventricular cardiomyocyte spheroids. By forming micro-tissue-like spheroids, retention rate and viability of cell transplant are improved. The expected mechanism of action is that the transplanted cardiomyocytes electrically couple with the patient's myocardium to improve cardiac output by remuscularization, and secretion of angiogenic factors to form new blood vessels around the transplant site (neovascularization).
LAPiS Study a 52-week, phase 1/2, open-label, dose-escalation study in patients with advanced heart failure caused by ischaemic heart disease, conducted at various study sites in Japan. The primary endpoint of the study is safety at 26 weeks post-transplantation, and secondary efficacy endpoints include left ventricular ejection fraction and myocardial wall motion.
For details: https://www.heartseed.jp/en/index.html
To view this piece of content from cts.businesswire.com, please give your consent at the top of this page.
View source version on businesswire.com: https://www.businesswire.com/news/home/20230525005069/en/
COO, Heartseed Inc.
About Business Wire
For more than 50 years, Business Wire has been the global leader in press release distribution and regulatory disclosure.
Subscribe to releases from Business Wire
Subscribe to all the latest releases from Business Wire by registering your e-mail address below. You can unsubscribe at any time.
Latest releases from Business Wire
Lenovo ranks Eighth in the Gartner® Supply Chain Top 25 for 202330.5.2023 20:11:00 EEST | Press release
Lenovo has once again been named in the Gartner Supply Chain Top 25 for 2023, ranking eighth in this list of global companies with supply chains. The Gartner Supply Chain Top 25 identifies, celebrates and profiles supply chain excellence on a global scale, and by target region and industry. Now in its 19th year, the global ranking is a peer benchmark for chief supply chain officers (CSCO) and their teams, inspiring innovation and leadership. The Supply Chain Top 25 ranking comprises two main components: business performance and opinion. Business performance in the form of public financial and ESG (environmental, social, governance) data provides a view into how companies have performed in the past three years, while the opinion component offers an eye to future potential and reflects leadership in the supply chain community. These two components are combined into a total composite score. Lenovo has fully embraced digital transformation within its complex and global supply chain, and by
Wemade’s MMORPG MIR M Reveals New Content ‘Monster Dungeon’30.5.2023 16:00:00 EEST | Press release
Wemade's MMORPG MIR M: Vanguard and Vagabond showcased new content, "Monster Dungeon," on May 30th. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20230530005249/en/ MIR M reveals new “Monster Invasion” content on May 30. (Graphic: Wemade) Users can obtain the "Demonic Stones" of field monsters they have defeated. Each "Demonic Stone" can be used to summon that monster in Monster Dungeon. By defeating all summoned monsters, users can obtain "Essence" items as rewards. "Essence" items can be registered to the Monster Codex to increase character stats. MIR M will be holding the event "Grand Operation Defeat Giant Scarecrow" until the update on June 13th. Users can defeat the Giant Scarecrow that appears in the Ginkgo Valley area to obtain gifts such as "Giant Scarecrow Raid Chests" and "Giant Scarecrow Demonic Stones." By using "Giant Scarecrow Demonic Stones," users can obtain Demonic Stones that can be used to summon boss mons
Q4 Inc. Set to Transform IR Effectiveness with Generative AI on the Q4 Platform30.5.2023 14:30:00 EEST | Press release
Q4 Inc. (TSX: QFOR) (“Q4” or “the Company”), the leading capital markets access platform, is excited to announce progress on pioneering generative artificial intelligence (“AI”) that is purpose built for Investor Relations (“IR”) effectiveness to help automate common tasks and accelerate decision making. By combining AI with the industry’s only end-to-end IR platform, IROs will be able to find insights exclusive to them built on a pool of their own proprietary program data and capital markets data aggregated on the Q4 Platform. “We are embarking on one of the most exciting product cycles in our history,” remarked Darrell Heaps, Founder and CEO of Q4. “Our offerings will unlock tremendous new opportunities for our clients to benefit from the unmatched richness and scale of our proprietary data with the integration of generative AI. The result for clients will simply be effective investor relations and better insights for our investment banking and equity capital markets clients.” In the
Kinaxis RapidResponse Available on Google Cloud Marketplace30.5.2023 14:00:00 EEST | Press release
Kinaxis ® Inc. (TSX: KXS), the authority in driving agility for fast, confident decision-making in an unpredictable world, announced today announced that the market’s leading supply chain management solution, Kinaxis RapidResponse® is available on Google Cloud and in the Marketplace. RapidResponse supports key business processes such as demand and supply planning, integrated business planning, sales and operations planning (S&OP) and inventory management, and delivers end-to-end transparency with its control tower capabilities. Concurrent planning breaks down organizational silos, unifies disparate data under a single all-inclusive data model, and codifies business-wide trust through the continuous alignment of everyone and everything across a company’s end-to-end supply chain. “We’re pleased the Kinaxis platform is now available on Google Cloud,” said Dai Vu, Managing Director, Cloud Marketplace & ISV GTM Initiatives at Google Cloud. “Customers can deploy Kinaxis via the Google Cloud
New Clinical Data on Vuse Illustrates Beneficial Public Health Impact of Tobacco Harm Reduction30.5.2023 13:00:00 EEST | Press release
New results from one of the largest ever vapour product studies, which analysed BAT’s flagship vapour brand Vuse, have been published in the journal of Internal and Emergency Medicine (https://link.springer.com/article/10.1007/s11739-023-03294-9). This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20230530005321/en/ One of the largest ever vapour product studies compared clinical measurements from exclusive Vuse consumers with smokers (Graphic: Business Wire) The study compared clinical measurements from exclusive Vuse consumers with smokers. The results of the study show that participating Vuse consumers had favourable differences in biomarkers of exposure (BoE) and biomarkers of potential harm (BoPH) relevant to smoking-related diseases when compared to smokers. Vuse users have shown significantly lower biomarkers of exposure for priority cigarette smoke toxicants as defined by the World Health Organization (WHO)iii. The data al
In our pressroom you can read all our latest releases, find our press contacts, images, documents and other relevant information about us.Visit our pressroom