Business Wire

Morinaga Milk Study Suggests Infant-Type Human-Residential Bifidobacteria May Benefit Infant Health by Improving Digestion of Peptides in Milk and Grains


Scientists at Morinaga Milk Industry Co., Ltd. (TOKYO:2264) have long theorized that Human-Residential Bifidobacteria (HRB) are superior to non-Human-Residential Bifidobacteria (non-HRB) in promoting good health outcomes. The results of a new study strengthen the evidence for this theory, showing that infant-type HRB may be able to break down incompletely digested peptides in the infants’ gastrointestinal systems and thus contribute to their overall health.

This press release features multimedia. View the full release here:

Fig 1. Food-derived opioid peptides are potential risk factors for human health (Graphic: Business W ...

Fig 1. Food-derived opioid peptides are potential risk factors for human health (Graphic: Business Wire)

Human-Residential Bifidobacteria for Humans

Morinaga Milk has been conducting research on bifidobacteria for many years, and studies over the past decades have shown that bifidobacteria play a vital role in various aspects of human health. There are two major groups of bifidobacteria: Human-Residential Bifidobacteria, which naturally reside in the human intestines, especially in infants, and non-Human-Residential Bifidobacteria, which are natural inhabitants of animals or the environment.

Research on the physiological properties that differentiate HRB and non-HRB species has made it clear that HRB are particularly effective at utilizing the human milk oligosaccharides (HMOs) in breast milk and are highly tolerant to lysozyme, a natural antibacterial factor present in human body. These characteristics allow HRB species to effectively colonize the infant gut, thereby contributing to the development and maturation of a healthy microbiome. Based on these findings, Morinaga Milk believes that HRB are beneficial, natural, and suitable for consumption by infants.

Opioid Peptides and Infant Health

Opioid peptides are peptides that bind to opioid receptors in the brain and can influence the release of neurotransmitters. Some opioid peptides are manufactured by the body, but others come from food. Incomplete digestion of proteins found in milk and cereals can create food-derived opioid peptides in the intestines. In healthy people, these peptides are hydrolyzed (or broken down) by enzymes and cause no harm. However, in the case of people with dysbiosis (impaired microbiota) or leaky gut, opioid peptides can cross the intestinal and blood-brain barriers, ultimately affecting the opioid and central nervous systems (Fig. 1). There is strong evidence that food-derived opioid peptides may cause serious diseases in sensitive people, such as those with mental disorders (Sokolov et al., 2014) and celiac disease (Hardy and Tye-Din, 2016, Kumar et al., 2017).

Because infants have an underdeveloped intestinal barrier, food-derived opioid peptides are more likely to cross into their brains. Consequently, infants with their immature central nervous systems are more susceptible to health disorders associated with opioid peptides, such as sudden infant death syndrome, atopic dermatitis, and autism. Considering these facts, Morinaga Milk conducted a study focused on the relationship between opioid peptides and infant health — specifically whether bifidobacteria can break down potentially harmful food-derived opioid peptides.

Degradation of food-derived opioid peptide

Morinaga Milk tested the ability of 18 strains of bifidobacteria, including both HRB and non-HRB, to degrade three different types of food-derived opioid peptides: beta-casomorphin-7 (BCM-7) from human milk, BCM-7 from bovine milk, and gliadorphin-7 (GD-7) from wheat gluten. Various strains of infant-type HRB proved capable of degrading food-derived opioid peptides much more effectively than strains of HRB more commonly found in adults or non-HRBs (Fig. 2). Several kinds of peptides were 100 percent hydrolyzed by infant-type HRB, while adult HRB and non-HRB never exceeded 15 percent hydrolyzation. This finding indicates the potentially crucial role of infant-type HRB in the intestines of infants to eliminate food-derived opioid peptides. The exact mechanisms of action by which infant-type HRB eliminate food-derived opioid peptides remain unclear, so more research is needed to better understand the ultimate impact of bifidobacteria on infant development. Morinaga Milk will continue to investigate the functional health benefits of HRB in humans.

About Bifidobacterium infantis M-63

Bifidobacterium infantis M-63 (MCC1872), which was proved capable of effectively degrading food-derived opioid peptides, is one of the best-studied HRB strains by Morinaga Milk. It is highly capable of utilizing human milk oligosaccharide in breast milk. M-63 is considered highly adapted to the intestinal environment of humans, especially infants. The results of an in vitro study show that M-63 prevented the growth of rotavirus. In addition, its efficacy for improving irritable bowel syndrome has also been substantiated in clinical studies.

About Morinaga Milk

Morinaga Milk Industry Co., Ltd., is one of the largest dairy product companies in Japan. Morinaga Milk excels in innovative technology and offers various dairy products and other beneficial functional ingredients to customers around the world. Morinaga Milk started research on bifidobacteria in the 1960s, inspired by the fact that bifidobacteria are the predominant bacteria residing in the intestines of breast-fed infants. In 1969, Morinaga Milk isolated its flagship strain Bifidobacterium longum BB536 from a healthy breast-fed infant. Since then, Morinaga has been conducting original research to contribute to healthy, fruitful lives for all people.
For more information about our probiotics and functional ingredients, please contact us at:

Contact information

Morinaga Milk Industry Co., Ltd.
Saki Yamashita, +81-3-3798-0152

Tietoja julkaisijasta

For more than 50 years, Business Wire has been the global leader in press release distribution and regulatory disclosure.

Tilaa tiedotteet sähköpostiisi

Haluatko tietää asioista ensimmäisten joukossa? Kun tilaat mediatiedotteemme, saat ne sähköpostiisi välittömästi julkaisuhetkellä. Tilauksen voit halutessasi perua milloin tahansa.

Lue lisää julkaisijalta Business Wire

FLIR Introduces Assisted Docking Technology and First Boat Manufacturer Partner22.1.2019 12:00Tiedote

FLIR Systems, Inc. (NASDAQ: FLIR) today announced the Raymarine DockSense™ assisted docking system, the marine industry’s first intelligent object recognition and motion sensing assisted docking solution for recreational boating. DockSense system uses FLIR machine vision camera technology and video analytics to integrate intelligence gathered from surrounding imagery with the vessel’s propulsion and steering system to assist boat owners in tight quarter docking maneuvering. Additionally, FLIR announced that Prestige Yachts, a Groupe Beneteau brand, will become the first to demonstrate the technology. This press release features multimedia. View the full release here: Docking a boat can be a stressful experience, even for the most experienced captains. Often wind and tides make the task more difficult, and docking mishaps can become expensive repairs and safety hazards. The DockSense system is designed to augment a captain's boat

BIOCERES and UNION ACQUISITION CORP. announce Bioceres’ unaudited quarterly operating results for the period ended December 31, 201822.1.2019 11:52Tiedote

Bioceres, a leading Latin American agricultural biotech company (the “Company”), and Union Acquisition Corp. (NYSE: LTN) (“UAC”), a special purpose acquisition company, today announced the Company’s unaudited operating results for the quarter ended December 31, 2018. The parties had previously announced the execution of a definitive share exchange agreement (the “Exchange Agreement”) pursuant to which the Company will contribute its agricultural solutions business in exchange for equity of UAC. The Company reported unaudited revenues of $62.6 million during the quarter ended December 31, 2018, which represents a 33% growth rate over the same period a year ago. The adjustments and the translation mechanism from the application of IAS 29 had a positive impact of $8.7 million during the quarter ended December 31, 2018. Additionally, the Company’s management team expects Gross Profit and EBITDA margin performance to exceed that of the same period a year ago. Members of UAC’s sponsor and, o

Tradeshift Announces Record Year and Exceptional Growth in Every Category Heading Into 201922.1.2019 11:00Tiedote

Tradeshift, the leader in supply chain payments and marketplaces, today announced results from the fourth quarter of 2018, marking the eleventh quarter in a row of successive growth and beating targets. Tradeshift’s fourth quarter growth stats announced today include: YoY new bookings grew 250 percent New total contract value grew by $59M in Q4 YoY revenue grew 178 percent (trailing 12 months) Gross Merchandise Volume (GMV) more than doubled, growing by 112 percent YoY Tradeshift Go experienced high growth with 12 deals signed in Q4 Signed App partner Transfermate, allowing Tradeshift customers to easily receive and make foreign currency payments Expanded Partner ecosystem with two additional BPO partners signed The company’s customer roster continued strong growth this quarter adding a record 49 new customers, including Charter Hall, HSBC, Econocom and more. “2018 was a record setting operational year for us,” said Christian Lanng, CEO and co-founder of Tradeshift. “It’s been so grati

Bridgestone Europe To Acquire TomTom Telematics For €910 Million Cash Consideration22.1.2019 09:58Tiedote

Bridgestone Europe NV/SA (“Bridgestone”), a subsidiary of Bridgestone Corporation in EMEA, has entered into an agreement with TomTom to acquire its telematics business, for a cash consideration of €910 million. The transaction will bring together the world’s largest tyre and rubber company with the number one provider of digital fleet solutions in Europe, creating a leading data platform for connected vehicles. TomTom Telematics will accelerate Bridgestone on its journey to becoming a mobility solutions leader in the region, and the combination of both companies’ offerings will allow Bridgestone to cross-sell tyres and solutions to a larger customer base. Furthermore, the data access will enhance Bridgestone’s virtual tyre development and testing as well as connected tyre innovation benefiting all customers including OEMs. New social, economic and technological megatrends are pushing the pace of change in the automotive industry and the future of vehicles is connected, autonomous, shar

GA Telesis Board Appoints Norman Liu as an Independent Director22.1.2019 09:00Tiedote

GA Telesis, LLC, a leading global commercial aviation integrated services provider, announces that its Board of Directors will appoint Norman C.T. Liu as an Independent Board Member effective February 1, 2019. Norm brings over 35 years of experience in aviation financing, infrastructure investing and investment banking. He is the former Chairman, President and CEO of GE Capital Aviation Services (“GECAS"), a world leader in commercial aircraft leasing and financing. He retired from GE at the end of 2016 after 30 years of service and is currently a senior advisor to various companies in the infrastructure and aviation sectors. He was an Advanced Leadership Fellow at Harvard in 2017 and also serves as an Adjunct Professor at University College Dublin in Ireland. He received his bachelor’s degree from Yale University and his MBA from Harvard Business School. “We are pleased that Norm will be joining our Board to participate in the explosive growth of our franchise,” said Abdol Moabery, Pr

Updated Analysis of Pivotal Study Reveals: Proactive, High Dosage of Venofer® Significantly Reduces Risk of Death or Major Cardiovascular Events in Haemodialysis Patients22.1.2019 09:00Tiedote

Regulatory News: This press release features multimedia. View the full release here: Further to the announcement on 29 October 2018, Vifor Pharma provides an update to the results of the Proactive IV irOn Therapy in haemodiALysis patients (PIVOTAL) trial. This update was necessitated by identification of a programming error in the original analysis by the investigators. The re-analysis of the data revealed a statistically significant improvement in the treatment effects of a higher dose of Venofer® (i.v. iron sucrose) compared with a lower dose. These results supersede those presented at the High-Impact Clinical Trial session at ASN Kidney Week 2018 and published on The New England Journal of Medicine website,, on 26 October 2018. The updated results can be viewed on: (DOI: 10.1056/NEJMoa1810742). In the updated results, the primary endpoint ‒ which was the composite of nonfatal myocardial infarction, nonfa

Uutishuoneessa voit lukea tiedotteitamme ja muuta julkaisemaamme materiaalia. Löydät sieltä niin yhteyshenkilöidemme tiedot kuin vapaasti julkaistavissa olevia kuvia ja videoita. Uutishuoneessa voit nähdä myös sosiaalisen median sisältöjä. Kaikki STT Infossa julkaistu materiaali on vapaasti median käytettävissä.

Tutustu uutishuoneeseemme