Business Wire

New data from Boehringer Ingelheim support the potential use of nintedanib in children and adolescents with fibrosing interstitial lung disease

Share

Today, Boehringer Ingelheim announced Phase III data from the InPedILD trial, which assessed the pharmacokinetics (dosing) and safety profile of nintedanib in children and adolescents between 6 and 17 years old with clinically significant fibrosing interstitial lung disease (ILD). The trial showed encouraging data for both primary endpoints and results were published in the European Respiratory Journal (ERJ) and presented at the European Respiratory Society International Congress (ERS) in Barcelona, Spain.1

“Based on the nintedanib mode of action, preclinical evidence and the clinical benefit in adults, there was a compelling rationale for examining its effect in children living with interstitial lung disease,” said the coordinating investigator, Prof. Robin Deterding, M.D., Director of the Breathing Institute, Children's Hospital Colorado. “This trial supports its potential use as a treatment with an acceptable safety profile for children and adolescents, for whom no approved evidence-based therapies exist.”

The InPedILD results showed that the weight-based dosing regimen of nintedanib in children and adolescents with fibrosing ILD resulted in comparable exposure to that observed in adult patients with fibrosing ILD. In addition, nintedanib had an acceptable safety and tolerability profile with no new safety signals observed when compared to adult patients with idiopathic pulmonary fibrosis (IPF), other progressive fibrosing interstitial lung disease (PF-ILD), and systemic sclerosis-associated interstitial lung disease (SSc-ILD).1 Based on these findings, regulatory applications will be submitted to the European Medicines Agency and U.S. Food and Drug Administration.

“While childhood interstitial lung diseases are very rare, their impact on children, teenagers and their loved ones can be devastating,” said Dr. Susanne Stowasser, Associate Head of Medicine Pulmonology at Boehringer Ingelheim. “The findings from InPedILD help meet the urgent need for well-characterized therapies for these children and adolescents living with ILD. These data further support Boehringer Ingelheim’s ongoing commitment to address unmet needs and advance research for people across all generations living with pulmonary fibrosis.”

Childhood interstitial lung disease (chILD) includes more than 200 rare disorders with debilitating symptoms that can include cough, difficulty breathing and rapid breathing.2,3 Its exact prevalence is unknown, but it can be considered very rare with a reported incidence ranging from 1.5 to 3.8 per million.2 Pulmonary fibrosis within chILD is even less frequent, with no known global prevalence estimates, and no international studies prior to InPedILD.2 chILD is associated with significant mortality and morbidity. When their condition deteriorates, many pediatric patients will need oxygen to go about their daily lives and require lung transplants.3,4 There are no established diagnostic criteria and few management guidelines.2,5,6 The current standard of care involves off-label use of treatments including steroids and steroid-sparing immunosuppressants, which have known adverse events and limited evidence for their use.2

Please click on the following link for ‘Notes to Editors’: https://www.boehringer-ingelheim.com/human-health/lung-diseases/pulmonary-fibrosis/new-data-nintedanib-children-fibrosing-ild

To view this piece of content from cts.businesswire.com, please give your consent at the top of this page.

Contact information

Boehringer Ingelheim
Corporate Communications
Media + PR

Dr Julia Fass
Phone: +49 (6132) 77 95614
Fax: +49 (6132) 77 6601
Email: press@boehringer-ingelheim.com

Additional information
www.boehringer-ingelheim.com

About Business Wire

For more than 50 years, Business Wire has been the global leader in press release distribution and regulatory disclosure.

Subscribe to releases from Business Wire

Subscribe to all the latest releases from Business Wire by registering your e-mail address below. You can unsubscribe at any time.

Latest releases from Business Wire

Seoul Semiconductor Participates in the World’s Biggest Lighting Expo Held in Germany to Showcase its High-Efficiency & Performance LED Lighting Systems30.9.2022 11:00:00 EEST | Press release

Seoul Semiconductor Co., Ltd. (KOSDAQ: 046890), a globally recognized optical semiconductor manufacturer, takes part in ‘Light + Building 2022’ held in Frankfurt, Germany, from October 2 to 6, 2022 to unveil its high-efficiency and high-performance LED lighting solutions. This lighting festival is one of the world’s largest lighting expos attended by more than 200,000 visitors from 55 nations in the world. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20220930005011/en/ [Photo] Seoul Semiconductor’s Booth for ‘Light + Building 2022’ (Photo: Business Wire) Seoul Semiconductor is expected to showcase differentiated lighting systems including ‘WICOP technology-based high-efficiency lighting solutions’ and ‘SunLike technology for reproducing natural light.’ WICOP high-efficiency lighting systems are mid- and high-power solutions that are mainly applied to landscape & horticulture lighting and street lamps. They outperform existin

Turkey is Calling Europe for Flight Trainings30.9.2022 10:30:00 EEST | Press release

Alfa Holding’s Aviation Services, Turkey’s rapidly growing private aviation services company, has met with leaders from European capitals to promote Turkey as a leading European flight training hub. Turkish civil aviation has received significant investment in recent years, developing into an important center for Europe in terms of civil aviation training. Turkey’s climate conditions and its first-rate, state-of-the-art equipped airports mean Turkey is vying with other countries to become a top aviation training hub in addition to offering other aviation-related businesses. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20220930005023/en/ Turkey is calling Europe for flight trainings (Photo: Business Wire) Alfa Aviation Services Chairman of the Board Mehmet Fatih Pakır, at his recent visit to France engaged in bilateral meetings with industry peers, commenting, “We are planning to cooperate with the European civil aviation aut

Enlighted Ushers in New Era of Smart Building IoT Data and Space Intelligence30.9.2022 10:01:00 EEST | Press release

Today Enlighted, a leading proptech company, released a curated portfolio of smart IoT building solutions to create customer value and further enable sustainable enterprises across industries and geographies. According to analyst firm Verdantix1, 75% of firms will use IoT data for space utilization monitoring. The solutions announced today, part of Siemens' open business platform Xcelerator, elevate the use of IoT building data to a new level of functionality for leaders seeking to improve productivity of their operations and to reach carbon neutrality. “We anticipate our new solutions and alignment with Siemens Xcelerator business platform will enable our customers to leverage their building’s IoT and activity data to vastly improve processes and decisions around the interactions of people and their spaces,” said Stefan Schwab, CEO, Enlighted. “Additionally, we will help them further transform their real estate portfolios with a focus on long-term sustainability to meet ESG goals. ” S

L&T Technology Services Joins Hands with Qualcomm to Provide Solutions for the Global 5G Private Network Industry30.9.2022 10:00:00 EEST | Press release

L&T Technology Services Limited (BSE: 540115, NSE: LTTS), a leading global pure-play engineering services company, today announced that it is collaborating with Qualcomm Technologies, Inc. to deploy end-to-end solutions for the global 5G Private Network Industry utilizing their combined core expertise in the Hi-Tech & Telecommunication domain. LTTS and Qualcomm Technologies will bring together core competencies in telecommunication solutions and services for the benefit of end-customers in the manufacturing and warehousing/logistics sector. As the demand for a connected world continues to grow rapidly, LTTS engineers are leveraging LTTS’ chip-to-cloud expertise to unleash the power of 5G and transform global manufacturing and supply chain processes. Qualcomm Technologies, an industry leader in 5G globally, is accelerating the expansion of 5G connectivity, and its end-to-end domain expertise is enabling the growth of the broader technology ecosystem spanning 5G Private Network RAN, devi

TRAWELL CO S.P.A. Confirms That Consumer Spending Is Strong in Airports Worldwide30.9.2022 09:05:00 EEST | Press release

The Board of Directors of TraWell Co S.p.A. (Euronext Growth Italia, ticker: TWL), which met yesterday afternoon, approved the consolidated half-yearly financial report as of 30 June 2022, which shows that passengers’ spending in airports is very strong. The group registered the following results for H1 2022: REVENUES of € 10.9 million, an increase of € 3.7 million (+ 52%); EBITDA equal to + € 2.0 million, up by € 2.2 million; NET PROFIT equal to + € 2.0 million, an increase of € 2.6 million. The revenues of 10.9 million euros (+ 52%) show a strong improvement of the spending environment compared to 2021. The analysis of Group’s revenues by geographical area confirms an ideal international diversification in H1 2022, with America as the first market of the Group with approximately 50% of revenues , Europe with 28% as the second market and Asia with approximately 22% of revenues. Rudolph Gentile, President and CEO of the TraWell Group: "Demand is high, and the industry is rebounding as

In our pressroom you can read all our latest releases, find our press contacts, images, documents and other relevant information about us.

Visit our pressroom