Business Wire

VALBIOTIS Selected to Present 3 Studies on TOTUM-63 by the European Association for the Study of Diabetes (EASD)

Share

Regulatory News:

VALBIOTIS (Paris:ALVAL) (FR0013254851 - ALVAL, eligible for the PEA/SME), a Research & Development company committed to scientific innovation for preventing and combating metabolic diseases, announces the selection of 3 studies on TOTUM-63 by the European Association for the Study of Diabetes (EASD), which will be presented at the association's annual meeting in September 2020.

For the third consecutive year, VALBIOTIS has seen its results on TOTUM-63, its active substance designed to reduce the risk of type 2 diabetes, selected by the main European diabetes meeting. This year, VALBIOTIS will present 3 studies at this major event, to be held from 22 to 25 September in virtual format due to the COVID-19 pandemic.

The clinical results of the international Phase II study of TOTUM-63 will first be presented by Prof. Jean-Marie Bard in the form of an e-poster (Abstract #621). Completed in the summer of 2019, this study showed a significant reduction in the main risk factors for type 2 diabetes (glycemic parameters, waist circumference, body weight) in prediabetic people, compared to a placebo. Already selected by the American Diabetes Association last June, these results have now been accepted by the two main scientific societies in the field of diabetes worldwide.

Murielle CAZAUBIEL, member of the Management Board and Director of Development and Medical Affairs at VALBIOTIS, comments: "The excellent results of the TOTUM-63 Phase II clinical study exceeded our expectations and enabled us to enter into a strategic partnership with Nestlé Health Science last February. In 2020, we have launched a strategy for the scientific communication of these results, which has already led to selection for presentations at the two largest diabetes meetings in the world, the ADA and EASD, within three months. These publications constitute indisputable recognition of the quality of our work. They are also a great source of pride and an additional incentive to complete the clinical development of TOTUM-63 with our partner Nestlé Health Science."

In addition to these clinical results, two preclinical studies demonstrating the positive effects of TOTUM-63 on obesity and carbohydrate metabolism disorders have also been selected by the EASD (Abstract #448 and #623). These studies highlight the efficacy of TOTUM-63 through two protocols: a protocol for the prevention of weight gain and associated metabolic disorders, carried out by the VALBIOTIS teams, and a protocol for the management of obesity and acquired disorders, carried out by the team of Dr Bruno Guigas (University of Leiden, Netherlands) with Vanderbilt University (Nashville, USA), one of the American expert centers for the study of diabetes. This preclinical work shows a reduction in body weight thanks to TOTUM-63 as well as an improvement in carbohydrate parameters in both protocols. It also provides a better understanding of the multi-targeted mode of action of TOTUM-63: reduced intestinal absorption of lipids and glucose, increased sensitivity of peripheral tissues to insulin and increased energy expenditure.

Pascal SIRVENT, member of the Management Board, Director of Discovery, Preclinical and Translational Research, states: "Since 2014, we have been conducting extensive preclinical work on TOTUM-63 in partnership with French and international universities, such as Leiden (the Netherlands) or Vanderbilt (USA) universities. These additional studies are essential, as they guide the clinical development of the active substances and document their mode of action. The two studies selected have demonstrated promising additional effects on the prevention and reversal of weight gain and its consequences on carbohydrate metabolism. We are now very proud to present them to the European diabetology community."

The three VALBIOTIS presentations at the EASD 2020 meeting are available at www.valbiotis.com/scientific-publications.

ABOUT TOTUM-63
TOTUM-63 is a unique and patented combination of 5 plant extracts that targets the physiopathological mechanisms of type 2 diabetes.
TOTUM-63 has already been shown to be safe and effective in healthy volunteers in a Phase I/II clinical study. Results of an international randomized, placebo-controlled Phase II study showed that TOTUM-63 reduced fasting and 2-hour blood glucose levels, two risk factors for type 2 diabetes, compared to placebo. In these subjects, who also had abdominal obesity, TOTUM-63 also significantly reduced body weight and waist circumference.
TOTUM-63 benefits from intellectual property that has been validated by the granting of patents in the main world markets: Europe (covering 39 countries), the United States and Russia, and national phases are underway in more than 20 countries including China, Japan, Brazil and Australia. TOTUM-63's industrial production capacity, in accordance with North American and European standards, has been validated. TOTUM-63 already has marketing authorizations linked to its status in Europe.
In February 2020, VALBIOTIS signed a long-term global strategic partnership with Nestlé Health Science for the development and worldwide marketing of TOTUM-63. This unique partnership in the field of Health Nutrition provides for the worldwide marketing of TOTUM-63 by Nestlé Health Science, possibly before obtaining a health claim depending on the region. It will also finance the final stages of development of TOTUM-63.

ABOUT VALBIOTIS
VALBIOTIS is a Research & Development company committed to scientific innovation for preventing and combating metabolic diseases in response to unmet medical needs.
VALBIOTIS has adopted an innovative approach, aiming to revolutionize healthcare by developing a new class of nutritional health solutions designed to reduce the risk of major metabolic diseases, based on a multi-target approach and made possible by the use of plant-based ingredients.
Its products are intended to be licensed to players in the health world.
VALBIOTIS was founded in La Rochelle in early 2014 and has formed numerous partnerships with top academic centers. The Company has established three sites in France – Périgny, La Rochelle (17) and Riom (63).
VALBIOTIS is a member of the “BPI Excellence” network and received “Innovative Company“ status awarded by BPI France. Valbiotis has also been awarded “Young Innovative Company” status and has received major financial support from the European Union for its research programs via the European Regional Development Fund (ERDF). VALBIOTIS is a PEA-SME eligible company.
Find out more about VALBIOTIS: www.valbiotis.com

Name: VALBIOTIS
ISIN code: FR0013254851
Mnemonic code: ALVAL

DISCLAIMER
This press release contains forward-looking statements about VALBIOTIS’ objectives, based on rational hypotheses and the information available to the company at the present time. However, in no way does this constitute a guarantee of future performance, and these projections may be affected by changes in economic conditions and financial markets, as well as a certain number of risks and uncertainties, including those described in the VALBIOTIS registration document, filed with the French Financial Markets Regulator (AMF) on 31 July 2020 (application number R 120--018). This document is available on the Company’s website (www.valbiotis.com).

This press release, as well as the information contained herein, does not constitute an offer to sell or subscribe to, or a solicitation to purchase or subscribe to, VALBIOTIS’ shares or securities in any country.

To view this piece of content from cts.businesswire.com, please give your consent at the top of this page.

Contact information

VALBIOTIS / CORPORATE COMMUNICATION
Carole ROCHER / Marc DELAUNAY
+33 5 46 28 62 58
media@valbiotis.com

ACTIFIN / FINANCIAL COMMUNICATION
Stéphane RUIZ
+33 1 56 88 11 14
sruiz@actifin.fr

About Business Wire

For more than 50 years, Business Wire has been the global leader in press release distribution and regulatory disclosure.

Subscribe to releases from Business Wire

Subscribe to all the latest releases from Business Wire by registering your e-mail address below. You can unsubscribe at any time.

Latest releases from Business Wire

Nordic Enterprises Embrace Cloud Services to Improve Customer Experience1.12.2021 12:00:00 EET | Press release

Enterprises in the Nordic region are increasing their spending on public cloud services and digital transformation to improve customer experiences, according to a new report published today by Information Services Group (ISG) (Nasdaq: III), a leading global technology research and advisory firm. The 2021 ISG Provider Lens™ Public Cloud – Services & Solutions Report for the Nordics finds enterprises in the region also increasing cloud spending to expand their product and service portfolios across the globe. In response, public cloud service providers are focused on improving their digital transformation advisory services. Cloud spending in the Nordics has increased across all industry verticals over the last five to six quarters. “Enterprises in the Nordic region have embraced the cloud and emerging digital technologies to become more cost effective and enhance customer experience,” said Jan Erik Aase, partner and global leader, ISG Provider Lens Research. “Companies are also looking fo

ATG to Use Ethical Hackers to Rein in Cybersecurity Challenges in Partnership With YesWeHack1.12.2021 12:00:00 EET | Press release

YesWeHack, Europe’s leading bug bounty platform has partnered with Sweden headquartered ATG, to identify potential vulnerabilities on its exposed assets. ATG provides quality excitement and entertainment through horse betting, sports betting and casino games for approximately 1.4 million customers. ATG is constantly evolving to meet new technology demands, increased data access, faster connections, and new digital channels. It is at the forefront of using digital technology to offer content-rich, personalised, and constantly available entertainment while meeting stricter regulation, digitalisation, and higher customer demands. Like other industries that retain extensive customer data, the sports betting and gambling industry is particularly vulnerable to cyber threats. In addition to the games themselves, ATG maintains databases that contain a wealth of private and financial information. It has payment systems and apps that hackers can target. Meanwhile, one of the most significant cha

Amazon Investing in 274 Renewable Energy Projects Globally, Adds 18 New Projects in Europe and U.S.1.12.2021 11:01:00 EET | Press release

Amazon (NASDAQ: AMZN) today announced 18 new utility-scale wind and solar energy projects across the U.S., Finland, Germany, Italy, Spain, and the U.K., totaling 5.6 gigawatts (GW) of procured capacity to date in 2021. Amazon now has 274 renewable energy projects globally and is on a path to power 100% of its business operations with renewable energy by 2025—five years earlier than its original 2030 commitment. These new utility-scale wind and solar projects bring Amazon’s total committed renewable electricity production capacity to more than 12 GW and 33,700 gigawatt hours (GWh) when the projects become fully operational, or electricity output equivalent to powering more than 3 million U.S. homes for a year. The projects will supply renewable energy for Amazon’s corporate offices, fulfillment centers, and Amazon Web Services (AWS) data centers that support millions of customers globally. The projects will also help Amazon meet its commitment to produce the clean energy equivalent of t

Calastone Announces Strategic Partnership With Microsoft to Accelerate the Digital Transformation of Funds and Collective Investments1.12.2021 11:00:00 EET | Press release

Calastone, the largest global funds network, has signed a partnership agreement with Microsoft, which will see the firms collaborate on the use of cloud and distributed ledger technology to create market efficiency across the global investment funds industry. By combining Calastone’s network, technology and market experience, with Microsoft’s expertise and track record in delivering capital markets solutions in Microsoft Azure, the companies will drive new opportunities for collective investments worldwide. Calastone is leveraging its network as the foundation on which to enable the asset management industry to realise its digital transformation agenda. As investor requirements grow for accessible, low cost and innovative ways of investing, Calastone is applying the very latest technologies to build the next generation infrastructure for the distribution of investment funds. Calastone introduced DMI Fund Services, a suite of solutions that provides fund managers, administrators and dis

Data Virtualization Can Deliver ROI of 408% According to New Independent Research Study1.12.2021 11:00:00 EET | Press release

Denodo, the leader in data virtualization, today revealed the findings of a new Total Economic Impact™ (TEI) study to demonstrate the tangible benefits of data virtualization using the Denodo Platform. The study, commissioned by Denodo and conducted by Forrester Consulting, quantified the financial impact of the solution and found Denodo customers achieved a return on investment of 408% and total economic benefits of a present value up to $6.8 million over three years. The complete, complimentary study can be found here. More specifically, the benefits to a blended organization that consists of long term Denodo customers include: 83% reduction in time-to-revenue 67% reduction in data preparation effort 65% decrease in delivery times over ETL According to the TEI study, “Data fabric technology takes the data virtualization a step further by automating data management functions using artificial intelligence/machine learning (AI/ML) and providing additional semantic capabilities through d

Rare Earth Metals Supply: The Next Microchip Crisis?1.12.2021 11:00:00 EET | Press release

With the heightened scrutiny of automotive contributions to climate change, automakers’ full attention is focused on electric vehicles (EVs). The electrification of transportation will help reduce reliance on fossil fuels, eliminate tailpipe emissions and help mitigate climate change. EVs, however, have a challenge: rare earth metals in their motors. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20211201005051/en/ Tula’s DMD™ Dynamic Motor Drive paired with synchronous reluctance motors (pictured here) could help lower EV production costs. (Photo: Business Wire) Rare earth metals are not rare in nature, but rarely are they concentrated in amounts that make extraction and processing economically feasible. Demand for rare earth metals is increasing in conjunction with the transition to an electrified future. The anticipated supply-demand imbalance, supply-chain management issues and escalating costs are causing automakers to lo

TaiwanPlus Curated Its First Film Festival to Showcase 10 Taiwanese Films Including Ang Lee’s Early Classics1.12.2021 10:39:00 EET | Press release

TaiwanPlus, a new global English-language video streaming service, has launched a Taiwan Cinema program with a selection of ten films that exemplify the diversity of Taiwan’s culture, peoples, and history. The most prominent collection is Ang Lee’s 'Father Knows Best' trilogy. Notably, this is the first time the films are available to be streamed online together. Director Lee’s strength in bringing together family members to create tension and tender comedic moments shine in this trio of PUSHING HANDS (1991), EAT DRINK MAN WOMAN (1994), and THE WEDDING BANQUET (1993). This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20211130006205/en/ Taiwan+ Film Festival 2021 is on! (Photo: Business Wire) Renowned actor Sihung Lung acts as the consummate traditional Taiwanese father in roles that evoke the sweet bitterness of an aging man trying to bring each casts’ family together. Hailed for their unrestrained portrayals of Eastern family dy

In our pressroom you can read all our latest releases, find our press contacts, images, documents and other relevant information about us.

Visit our pressroom