4Moving Biotech announces successful results from its Lasare Phase I 4P004 Clinical Trial intraarticular Liraglutide for knee osteoarthritis patients
4Moving Biotech, a spin-off of 4P-Pharma committed to developing first-in-class treatments to modify the natural course of knee osteoarthritis, announces the successful achievement of the Phase 1 Lasare trial in knee osteoarthritis (OA) patients using 4P004.
This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20240609275171/en/
(Graphic: Business Wire)
Lasare Phase I trial is a multi-center, randomized, double-blinded, placebo-controlled involving 34 patients across three sites in Belgium.
The study evaluated the safety, tolerability, and pharmacokinetics of ascending doses of a single intra-articular injection of liraglutide (4P004).
The trial reached its primary objective, confirming that intraarticular liraglutide (4P004) was safe and well tolerated. A pharmacological active dose has been identified, with similar expected adverse events (EAEs) in the 4P004 groups as the placebo group. Pharmacokinetics, both observed and simulated Cmax values, also indicated lower systemic exposure than reported for subcutaneous liraglutide injection from the approved product, Victoza®, affirming the company’s plan to pursue a 505(b)(2) regulatory pathway in the US for 4P004.
Pr. Francis Berenbaum, Co-founder and Chief Medical Officer of 4Moving Biotech, declared: "The Success of the Phase 1 study of 4P004 underscores the quality of our advancements in the quest for therapeutic solutions for patients suffering from knee osteoarthritis. Furthermore, with the established safety and tolerability profiles, we are progressing confidently to the next stage of clinical development with 4P004."
As for ultimate goal, 4Moving Biotech’s strategy intends to secure accelerated approvals in the US and EU for early market entry at the end of the planned Phase 2b efficacy and safety trial. Toward this goal, the company recently received constructive pre-IND guidance from the FDA, translating 4Moving Biotech’s planned potential accelerated approval driven strategy into a highly differentiated clinical program catalyzed by a unique combination of reasonably likely surrogate endpoints, supported by sophisticated in silico AI-based prognostic modelling.
Revital Rattenbach, Chairwoman of 4Moving Biotech, stated: "Beyond the positive results from our phase I clinical study on knee osteoarthritis, the FDA's positive echoing has built a tremendous momentum for our accelerated strategy to the market, with hopes to bring to OA patients the first therapy being able to modify the natural course of the disease."
About 4Moving Biotech
Incorporated in mid 2020 as a spin-off of 4P-Pharma, 4Moving Biotech is a clinical stage biotechnology company dedicated to the development of the Disease-Modifying Osteoarthritis Drug (DMOAD). Its mission is to provide a sustainable therapeutic solution to the significant unmet medical need of osteoarthritis. The company is headquartered at the Pasteur Institute in Lille, France.
Website: https://www.4movingbiotech.com/
LinkedIn: https://fr.linkedin.com/company/4moving-biotech
About Lasare
This project has received funding from the Eurostars-2 joint program with co-funding from the European Union Horizon 2020 research and innovation program. The funding agencies supporting this work are (in alphabetical order of participating countries): France: BPI France ; Germany: Project Management Agency (DLR), which acts on behalf of the Federal Ministry of Education and Research (BMBF); The Netherlands: Netherlands Enterprise Agency (RVO); Switzerland: Innosuisse (the Swiss Innovation Agency).
The only version of the 4Moving Biotech press release that is legally binding is the one in its original language. Translations must always be compared to the source text, which will establish precedence. The press release text resulting from a translation should not be considered official in any way.
To view this piece of content from cts.businesswire.com, please give your consent at the top of this page.
View source version on businesswire.com: https://www.businesswire.com/news/home/20240609275171/en/
Contact information
Press :
Emmanuel Dadje
Communication Manager
+33 6 30 06 12 13
emmanuel.dadje@4P-Pharma.com
About Business Wire
For more than 50 years, Business Wire has been the global leader in press release distribution and regulatory disclosure.
Subscribe to releases from Business Wire
Subscribe to all the latest releases from Business Wire by registering your e-mail address below. You can unsubscribe at any time.
Latest releases from Business Wire
Logical Intelligence Achieves 76 Percent on Putnam Benchmark, Highlighting Shift Beyond Large Language Models to Language-free, Mathematically Grounded Models2.12.2025 16:15:00 EET | Press release
Over the last decade, artificial intelligence (AI) has been largely built around large language models (LLMs). These systems are based on a language and guess words in a chain in the form of tokens. As a result, they frequently hallucinate and require vast compute and power infrastructure to solve tasks. The moment systems like public safety, national infrastructure, and industrial automation need logic, LLMs break and introduce safety risks. Token-free language independent models represent a new direction for AI. They do not predict words. They search for correct solutions and require less compute. Logical Intelligence is the first company building exclusively around mathematically derived, non autoregressive EBM (Energy Based Model) reasoning. Today, Logical Intelligence announced that its Aleph tool achieved a 76 percent score on the Putnam Benchmark, one of the most demanding mathematical reasoning tests in artificial intelligence. The benchmark measures a model’s ability to solve
Ullevaal Stadium Among the First in the World to Install FIFA Quality Pro Certified LED Lighting System2.12.2025 16:15:00 EET | Press release
A newly installed, state-of-the-art LED lighting system at Ullevaal Stadium has transformed the playing, viewing, and entertainment experience for athletes and spectators, and has made Norway’s national stadium one of the few in the world with FIFA Quality Pro Certification. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20251201171907/en/ The state-of-the-art TLC for LED® lighting system at Ullevaal Stadium has made Norway’s national stadium one of the few in the world with FIFA Quality Pro Certification. Home to Norway’s national football team, Ullevaal Stadium opened in 1926 and has a rich history of hosting significant sporting and entertainment events. When stadium ownership at the Football Association of Norway (NFF) decided to upgrade the venue’s lighting, they envisioned a system with the most advanced LED technology for the best possible playing, viewing, and entertainment experience. “Our main priorities for the new
MUSASHI JAPAN Launches “Gift Campaign 2025” - A Holiday Tradition Honoring Craftsmanship Through Meaningful Gifts2.12.2025 16:07:00 EET | Press release
MUSASHI JAPAN by TAIMATSU announces the return of its year-end celebration, Gift Campaign 2025, a seasonal tradition that transforms holiday shopping into an experience of appreciation, craftsmanship, and cultural generosity. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20251202812444/en/ Rather than focusing on discounts, MUSASHI embraces the philosophy that true value lies in tools that last and in the gestures that accompany them. This year’s campaign invites customers to discover gifts that enrich their craft in the kitchen, each thoughtfully chosen to support the longevity and performance of every Musashi blade. Inspired by the Japanese principle of omotenashi, the campaign offers customers tiered gifts based on their total purchase amount, ensuring that every contribution is met with gratitude and purpose. From December 2 to December 25, 2025, customers shopping in MUSASHI JAPAN stores will receive: Tier 1: Oil and Rus
Invisible IT Emerges as Workplace Transformation Evolves, Lenovo Research Finds2.12.2025 16:00:00 EET | Press release
The next step in workplace transformation is invisible technology that fades into the background so that support is automated and seamless, according to a Lenovo global survey of IT leaders released today. Most employees only notice IT when it slows them down and interrupts processes. Invisible IT is the opposite. It means technology that anticipates needs, prevents issues before they happen, and personalizes support automatically. Achieving Invisible IT, the newest report in Lenovo’s ongoing Work Reborn series, explores how AI and automation are redefining the digital workplace and employee experience. Of the IT leaders who participated, 79% aspire to deliver seamless, proactive support that minimizes disruption for employees, but only 21% have achieved predictive issue resolution. The results underscore an urgent need for organizations to remove digital barriers, simplify IT ecosystems, and adopt AI-enabled, hyper-personalized support that delivers a truly effortless employee experie
Xsolla Advances Global Gaming Education and Innovation in Collaboration With HP2.12.2025 16:00:00 EET | Press release
Xsolla, a leading global video game commerce company that helps developers launch, grow, and monetize their games, today announced a strategic relationship with HP to connect education, technology, and entrepreneurship across the global games industry. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20251202381208/en/ Rytis Joseph Jan, SVP Global Strategic Initiatives & Partnerships at Xsolla The collaboration combines HP’s Gaming Garage learning platform with Xsolla’s Accelerator to create an end-to-end ecosystem that enables aspiring creators to learn, build, and launch their own studios. The integration acts as a catalyst for global opportunities for innovation, introducing new models for game education, incubation, and professional development on a large scale. The program includes pilot programs starting in Saudi Arabia, Azerbaijan, and the United Arab Emirates with a goal to reach over 100,000 students and young creators
In our pressroom you can read all our latest releases, find our press contacts, images, documents and other relevant information about us.
Visit our pressroom