Biocytogen Announces RenLite® Licensing Agreement with Janssen
8.3.2023 16:25:00 EET | Business Wire | Press release
Biocytogen Pharmaceuticals (Beijing) Co., Ltd. ("Biocytogen") (HKEX: 02315), today announced the signing of a non-exclusive license agreement with Janssen Biotech, Inc., one of the Janssen Pharmaceutical Companies of Johnson & Johnson (“Janssen”). Under the agreement, Biocytogen grants Janssen and its affiliates a non-exclusive worldwide license to use Biocytogen’s proprietary RenLite® platform and underlying intellectual property to discover, research, develop, manufacture and commercialize fully human antibody therapeutics with a common light chain and other biological therapeutics for an unlimited number of drug targets and indications. The agreement was facilitated by Johnson & Johnson Innovation LLC.
RenLite® is a member of Biocytogen's fully human antibody RenMice™ family. RenLite® mice can generate fully human antibody candidates with high specificity, affinity, diversity and good druggability, with a common light chain for subsequent assembly of bispecific and multispecific antibodies with a low mismatch and high success rate. The bispecific and multispecific antibodies assembled after RenLite® discovery have a traditional antibody structure and exhibit ideal physiochemical properties that are advantageous for downstream CMC development.
Dr. Yuelei Shen, Founder, Chairman and CEO of Biocytogen, said: “We are pleased to partner with Janssen to accelerate the discovery of new antibody-based drugs for patients.”
About RenMice™
RenMice™ are Biocytogen’s proprietary genetically modified mice that generate antibodies with fully human variable domains. The models, which include RenMab™, RenLite® and RenNano® mouse platforms, as well as substrains containing additional modifications, were developed using Biocytogen’s size-unlimited, precise chromosome engineering technology (SUPCE), which allows for in situ replacement of the murine immunoglobulin genes with their human counterpart. All RenMice platforms contain the entire human heavy chain VDJ loci, with the RenMab mouse harboring all human light chain VJ loci. In contrast, the RenLite mouse contains a single human VJ locus in situ to facilitate future bispecific antibody assembly, while the RenNano mouse has modified heavy chain constant regions to generate functional heavy-chain-only antibodies (HCAbs).
RenMice can generate robust immune response and produce fully human antibodies with great diversity, specificity, affinity and druggability. The development of RenMice has allowed Biocytogen to launch 6 fully human antibody discovery platforms: monoclonal antibody (RenMab), bispecific antibody and bispecific ADC (RenLite), nanobody (RenNano), TCR-mimic antibody for intracellular targets (HLA/RenMice, i.e., MHC humanized RenMice), and a RenMice HiTS (hyperimmune target specific) antibody platform designed for GPCR and other challenging targets.
As of June 30, 2022, RenMice have been licensed by 16 biopharmaceutical companies around the world, including Merck KGaA, Xencor, BeiGene, and Innovent.
About Biocytogen
Biocytogen (HKEX: 02315) is a global biotechnology company that drives the research and development of novel antibody-based drugs with innovative technologies. Using its proprietary RenMab™/RenLite®/RenNano® mice platforms for fully human monoclonal, bispecific/multispecific antibody and nanobody development, respectively, Biocytogen has integrated its in vivo drug efficacy screening platforms and strong clinical development expertise to streamline the entire drug development process. Biocytogen is undertaking a large-scale project to develop first-in-class and/or best-in-class antibody drugs for more than 1000 targets, known as Project Integrum. As of June 30, 2022, this project has resulted in 28 drug co-development agreements and 16 RenMice™ licensing agreements with companies around the world, including several partnerships with multinational pharmaceutical companies (MNCs). Biocytogen's internal pipeline includes 12 core products, among which two products are in phase II multi-regional clinical trials and two products are in phase I. Headquartered in Beijing, Biocytogen has branches in Haimen Jiangsu, Shanghai, Boston, USA and Heidelberg, Germany. For more information, please visit http://en.biocytogen.com.cn.
To view this piece of content from cts.businesswire.com, please give your consent at the top of this page.
View source version on businesswire.com: https://www.businesswire.com/news/home/20230308005504/en/
Contact information
Biocytogen’s Contacts
Antibody platforms and antibody assets: BD-Licensing@biocytogen.com
Media: pr@bbctg.com.cn
About Business Wire
For more than 50 years, Business Wire has been the global leader in press release distribution and regulatory disclosure.
Subscribe to releases from Business Wire
Subscribe to all the latest releases from Business Wire by registering your e-mail address below. You can unsubscribe at any time.
Latest releases from Business Wire
Loomis Sayles Euro Credit Team Celebrates Five-Year Milestones26.2.2026 18:00:00 EET | Press release
Loomis, Sayles & Company, the century-old investment manager with €363.8 billion in assets under management, celebrates the five-year anniversaries of its Loomis Sayles Euro Credit and Loomis Sayles Euro High Yield strategies. The Loomis Sayles Euro Credit Team, led by Co-Heads and Portfolio Managers Rik den Hartog and Pim van Mourik Broekman, manages €3.5 billion in assets across three strategies. Backed by Loomis Sayles’ industry-leading technology infrastructure and focused investment culture, the Euro Credit team seeks to generate consistent excess return versus the benchmark. The team believes this can be accomplished by using an active, conservative alpha investment process that aims to capitalize on inefficiencies in the euro credit market. Loomis Sayles Euro Credit invests primarily in investment grade, euro-denominated corporate bonds while Loomis Sayles Euro High Yield invests primarily in the BB segment of the euro-denominated high yield corporate bond market. The team’s Loo
Omani and Jeanie Carson Named Inaugural Departure Day Dove 1 for 2026 Special Olympics Airlift, Donating Aircraft and Crew to Lead Athletes Home26.2.2026 18:00:00 EET | Press release
Textron Aviation Inc., a Textron Inc. (NYSE: TXT) company, today announced that Omani and Jeanie Carson, of Omaha, Nebraska, have been named the inaugural departure day Dove 1 for the 2026 Special Olympics Airlift. The Carsons will donate their aircraft and crew to lead athletes home at the conclusion of the Games, marking the first year this honorary departure day distinction has been established. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20260226250477/en/ Omani and Jeanie Carson named inaugural departure day Dove 1 for 2026 Special Olympics Airlift, donating aircraft and crew to lead athletes home (Photo credit: Textron Aviation). As departure day Dove 1, the Carsons will guide the first aircraft lifting off from Minneapolis’ Twin Cities on Saturday, June 27, reuniting athletes with their families, hometowns and communities after a week of competition, determination and unforgettable experiences. This newly established
Andersen Consulting Expands Digital Transformation Offering with Aesys26.2.2026 16:30:00 EET | Press release
Andersen Consulting announces a Collaboration Agreement with Italian-based firm Aesys, strengthening its capabilities in technology and systems integration. Founded in 2013, Aesys is a digital technology and systems integration firm delivering end-to-end IT solutions. The firm combines expertise in software development, cloud computing, machine learning, and cybersecurity with a strong track record in banking and automotive systems integration, helping organizations accelerate digital transformation and strengthen technology infrastructure. “Through this collaboration, we can bring even greater value to clients by combining our deep expertise in systems integration with Andersen Consulting’s global platform,” said Samuel Roberto, international business manager of Aesys. “Together, we will help organizations strengthen their technology foundations, adopt innovative solutions in areas such as machine learning and cybersecurity, and achieve sustainable digital transformation.” “This agree
New Lenovo Service Delivers Always-On Infrastructure: Premier Support Plus for Servers Powered by Proactive, AI-Driven Support26.2.2026 16:00:00 EET | Press release
Lenovo today announced the availability of Lenovo Premier Support Plus for Servers, a new premium support offering designed to help enterprises reduce downtime, simplify IT operations, and keep mission-critical infrastructure always ready. Built for today’s always-on environments, Premier Support Plus combines AI-driven proactive and predictive support, preventative maintenance, 24/7 access to Lenovo experts, and designated Service Engagement Managers to help organizations move from reactive issue resolution to proactive system care. As digital operations continue to expand and infrastructure environments grow more complex, IT teams are under increasing pressure to maintain uptime while managing limited resources. Traditional, reactive support models can lead to extended outages, repeated issues, and unpredictable costs. Lenovo Premier Support Plus for Servers addresses these challenges by identifying potential issues early and resolving them before they impact business operations. “Wi
Sitetracker Closes 2025 with Strong Momentum, Product Expansion, and a Clear Path into 202626.2.2026 16:00:00 EET | Press release
Sitetracker, the global leader in complete Asset Lifecycle Management for critical infrastructure, today announced strong year-end results for 2025, marked by continued customer growth, expansion into new infrastructure markets, and major product innovations across operations, maintenance, and financial management. As infrastructure owners and operators face growing pressure to scale without adding headcount, Sitetracker enters 2026 positioned to help customers operate smarter, move faster, and unlock greater productivity. 2025 Highlights In 2025, Sitetracker delivered another year of growth and execution across its global customer base: Customer growth and market expansion: Sitetracker now serves more than 400 customers globally, supporting organizations across digital infrastructure, renewables, EV charging, utilities, and emerging infrastructure markets including data centers. Enhanced Operations & Maintenance capabilities: Sitetracker now connects field operations and work order ma
In our pressroom you can read all our latest releases, find our press contacts, images, documents and other relevant information about us.
Visit our pressroom