Biocytogen Launches “Nano 100 Project” to Develop Fully Human Nanobody Therapeutics for Over 100 Targets
Biocytogen Pharmaceuticals (Beijing) Co., Ltd. ("Biocytogen", HKEX: 02315) today announced the launch of the “Nano 100 Project”, which aims to develop fully human nanobody drugs for over 100 targets. The Project combines Biocytogen’s proprietary fully human nanobody mouse, RenNano®, with its high-throughput in vitro and in vivo antibody screening platforms to develop fully human nanobody drugs on a large-scale.
Compared to traditional antibodies, nanobodies have smaller molecular weights and improved tissue penetration ability, which make them effective at infiltrating tumors and crossing blood-brain barriers. Additionally, nanobodies generally have longer CDR3 regions which enables them to recognize hidden epitopes better. Due to their simpler structure, nanobodies are more stable and easier to produce and engineer, making them ideal building blocks for complex modalities such as cell therapy, bispecific antibody and engager, multi-specific antibody, antibody drug-conjugate (ADC), and radionuclide antibody-conjugate (RAC).
After several years of endeavor, Biocytogen successfully engineered the RenNano mouse from its fully human antibody mouse, RenMab™. RenNano mouse possesses full human heavy chain variable regions and can produce heavy-chain-only antibodies (HCAbs). The variable regions of HCAbs, i.e., nanobodies, do not require in vitro humanization to develop drugs. Our research has shown that RenNano mouse can generate robust immune responses after immunizations by different antigens. HCAbs generated from the RenNano mouse have highly diverse CDR3 sequences and can recognize many epitopes with nM-level high affinities. In vitro and in vivo experiments have shown that RenNano-derived antibodies have favorable biological functions.
Based on RenNano’s excellent ability to discover fully human nanobodies, Biocytogen has launched the “Nano 100 Project”. The Project aims to develop fully human therapeutic nanobodies against over 100 targets, including tumor associated antigens (TAAs), GPCRs, immune-checkpoints, cytokines, and factors related to neurological diseases. Biocytogen is actively seeking collaborations with global pharmaceutical and biotech companies to combine its large-scale nanobody development abilities with collaborators’ expertise in nanobody-related therapeutics, such as cell therapies, bispecific and multi-specific antibodies, ADCs and RACs, to develop novel drugs with first-in-class and/or best-in-class potentials.
“We believe that with the ability to rapidly develop fully human nanobodies against selected targets, the ‘Nano 100 Project’ will provide our global partners with more diverse and better nanobody building blocks to accelerate the development of novel drugs,” said Dr. Yuelei Shen, President and CEO of Biocytogen. “Meanwhile, it is also an important supplement to Biocytogen’s Project Integrum.”
Biocytogen's proprietary fully human nanobody generating mouse, RenNano, is one of the most comprehensive fully human antibody platforms in the world. Nanobody sequences generated from RenNano mice have the highest possible diversity and do not require antibody humanization, which saves time and cost and reduces the risk of failure during later stages of drug development. Additionally, compared to natural HCAb-producing species like camelids, mice are easier to breed and immunize, making them suitable for developing HCAbs on a large scale.
Biocytogen (HKEX: 02315) is a global biotechnology company that drives the research and development of novel antibody-based drugs with innovative technologies. Using its proprietary RenMab™/RenLite®/RenNano® mice platforms for fully human monoclonal antibody, bispecific/multispecific antibody and nanobody development, Biocytogen has integrated its in vivo drug efficacy screening platforms and strong clinical development expertise to streamline the entire drug development process. Biocytogen is undertaking a large-scale project to develop first-in-class and/or best-in-class antibody drugs for more than 1000 targets, known as Project Integrum. This project has resulted in 28 drug co-development agreements and 16 RenMice™ licensing agreements with companies around the world, including several partnerships with multinational pharmaceutical companies (MNCs). Biocytogen's pipeline includes 12 core products, among which two products are in phase II multi-regional clinical trials and two products are in phase I. Headquartered in Beijing, Biocytogen has branches in Haimen Jiangsu, Shanghai, Boston, USA and Heidelberg, Germany. For more information, please visit http://en.biocytogen.com.cn.
To view this piece of content from cts.businesswire.com, please give your consent at the top of this page.
View source version on businesswire.com: https://www.businesswire.com/news/home/20230221005554/en/
Antibody platforms and antibody assets: BD-Licensing@biocytogen.com
About Business Wire
For more than 50 years, Business Wire has been the global leader in press release distribution and regulatory disclosure.
Subscribe to releases from Business Wire
Subscribe to all the latest releases from Business Wire by registering your e-mail address below. You can unsubscribe at any time.
Latest releases from Business Wire
Laserfiche Recognized as a Strong Performer in Independent Analyst Report on Content Platform Providers24.3.2023 21:38:00 EET | Press release
Laserfiche — the leading SaaS provider of intelligent content management and business process automation — has been named a Strong Performer in The Forrester Wave™: Content Platforms, Q1 2023. Laserfiche was one of 13 vendors evaluated on the strength of its strategy and current offering. Laserfiche earned the highest rating possible in seven criteria: Packaged Applications Search Lifecycle Management Developer Resources App Design/Development Tools Commercial Model Intelligent document extraction According to the report, “Laserfiche has successfully transitioned its 30-plus-year track record in content management into a modern SaaS platform with a well-balanced set of services to deliver a very broad range of vertical and horizontal apps. Its product vision focuses on deeper integration of analytics, structured data sources, and AI/ML, prioritized to align to the needs of its well-defined verticals.” The report also states, “Organizations, including larger enterprises, looking for a S
Q4 Inc. Ranks on The Globe and Mail’s Women Lead Here Benchmark of Executive Gender Diversity24.3.2023 16:15:00 EET | Press release
Q4 Inc. (TSX: QFOR) (“Q4” or “the Company”), a leading capital markets communications platform provider, is proud to announce it has been included on The Globe and Mail’s 2023 Report on Business magazine’s Women Lead Here list. This annual editorial benchmark identifies top-notch Canadian businesses with the highest executive gender diversity. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20230324005019/en/ The Executive Women Leaders of Q4 Inc. - Pictured from left to right are Dorothy Arturi, CPO; Lorie Coulombe, SVP, Marketing & Communications; and Donna de Winter, CFO & COO. (Photo: Business Wire) This benchmark was established in 2020 by Report on Business magazine and applies a proprietary research methodology to determine Canadian corporations with the highest degree of gender diversity among executive ranks. The ranking companies have made tangible and organizational progress related to executive gender parity. “I am
ClickHouse, Inc. and Alibaba Cloud Announce a New Partnership24.3.2023 16:00:00 EET | Press release
Today, ClickHouse, Inc., creators of ClickHouse online analytical processing (OLAP) database, and Alibaba Cloud, the digital technology and intelligence backbone of Alibaba Group, announced a partnership that will enable Alibaba Cloud to offer ClickHouse as an enterprise, first-party service on its platform. This partnership is an exclusive agreement between ClickHouse, Inc. and Alibaba Cloud in mainland China to offer a joint first-party enterprise service in APAC. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20230324005222/en/ Aaron Katz, Founder & CEO, ClickHouse, Inc. (Photo: Business Wire) ClickHouse is the world's fastest and most resource-efficient analytical database, and since it was released as an open-source project in 2016, adoption has grown exponentially – globally. Organisations large and small benefit from the blazing fast speed - with peak processing performance for a single query standing at more than two t
Westlake Epoxy Promoting NEW AZURES™ Systems24.3.2023 13:00:00 EET | Press release
Westlake Corporation (NYSE: WLK) today announced that Westlake Epoxy will launch its new AZURES™ product range at the European Coatings Show 2023, to be held in Nuremberg, Germany, March 28 to 30, 2023. Westlake Epoxy’s Azures™ products are newly developed epoxy resins, modifiers and curing agents that are free of any SVHC- and CMR-labelled substances. As such, they provide better sustainable alternatives to existing technologies used in coatings, civil engineering and adhesives while keeping the same level of performance. “This is definitely another important milestone in Westlake Epoxy’s strategy to contribute to a safer and cleaner world,” said Ann Frederix, Vice President, Westlake Epoxy. Recently, Westlake Epoxy’s European business also confirmed its receipt of the 2022 Platinum Medal from EcoVadis, the world’s largest and most trusted provider of business sustainability ratings, and Westlake Epoxy’s Pernis, Netherlands site has successfully passed the audit for its International
Fischbein International and Votech Expand Manufacturing Footprint in Reusel and Announce New Company Name as Votech, a Duravant Company24.3.2023 11:00:00 EET | Press release
Votech announced today the grand opening of their newly expanded manufacturing facility and company headquarters in Reusel, The Netherlands. This marks the completed integration of two renowned leaders in the packaging industry, Fischbein International and Votech, who came together in 2021 through the acquisition of Votech by Duravant, a global engineered equipment and automation solutions provider to the Food Processing, Packaging and Material Handling sectors. The merger brought together 100+ years of packaging expertise and created a portfolio of technologies that expands the company’s ability to serve customers across a wide array of end markets including agriculture, animal nutrition, fruits and vegetables, ingredients, milk powders and other industrials. Alongside this announcement, the company unveiled their new company logo and brand campaign that reflects the organization’s transformation into a full-line packaging equipment provider. “The names Fischbein, Saxon and Votech, al
In our pressroom you can read all our latest releases, find our press contacts, images, documents and other relevant information about us.Visit our pressroom