Business Wire

Biosense Webster Launches a Two-pronged Initiative to Tackle the New Millennium Epidemic of Atrial Fibrillation

Share

Biosense Webster EMEA, a Division of Johnson & Johnson Medical NV/SA and leader in the treatment of Atrial Fibrillation (AF) has today reaffirmed its commitment to tackling this new millennium epidemic by launching two major initiatives to coincide with Global AF Aware Week, 18-24 November 2019. Get Smart About AFIB (GSAAF) is a campaign where Arrhythmia Alliance and Biosense Webster have partnered to improve knowledge of AF across the healthcare community and the general public. Alongside this campaign, the Atrial Fibrillation Management Report examines the available treatment options for AF across Europe and their long-term impact on clinical, patient and economic outcomes, aiming to support healthcare professionals (HCPs) when making treatment decisions.

The Atrial Fibrillation Management Report reviewed independent studies to explore current treatment options for AF patients, which include antiarrhythmic drugs (AADs) and catheter ablation. Key findings highlighted that just half of patients (52%) are well-managed by AADs,1 yet despite this, just 4% of eligible patients receive catheter ablation2 – a treatment that’s almost 10 times more effective in delaying disease progression than AADs, as demonstrated by the ATTEST trial.3 Furthermore, the report found catheter ablation to be a highly effective and economical treatment option, with data showing:

  • Greater improvement on patients’ quality of life (37% vs. 18% for AADs)4, 5
  • Sustained results with 94% patients free from arrhythmia recurrence after one year and 48% free from arrhythmia after four years6-16
  • Up to 46% lower incidence of death, stroke, cardiac arrest and cardiovascular hospitalization over seven years, compared to AADs16, 17
  • Reduced need of unplanned medical visits (by up to 80%) and long-term cost savings of 35%18, 19

AF is a growing health epidemic and places a critical financial burden on healthcare systems, costing up to €3,286 million annually in some European countries.20 By 2030, the number of people with AF is projected to increase by up to 70%34 and by 2050 Europe will have the greatest increase in AF patients compared to other regions globally, owing to factors such as economic growth, an ageing population and increased prevalence of risk factors for AF in Western countries. 21, 22 In addition, AF is sometimes known as a silent killer because up to 30% of patients do not experience any symptoms. 23,24,25

Arrhythmia Alliance and Biosense Webster have come together with a strong commitment to helping patients receive diagnosis and treatment more quickly and effectively through education, with an aim to reduce the burden of AF. Get Smart About AFIB provides easy-to-access information to help educate the general public about the condition, its common symptoms and the importance of treatment. From here, patients can ask their doctor to advise on management and treatment options available for AF. Educational materials have also been created for cardiologists, general practitioners and the wider healthcare community to support their work in diagnosing and treating AF.

“Patients with AF have a lower quality of life than the general public. AF can lead to AF-related stroke, heart failure, dementia and the condition can have a costly impact on healthcare systems,” said Trudie Lobban MBE, Founder & Trustee of Arrhythmia Alliance. “It is, therefore, crucial that we do everything we can to raise awareness of AF to prevent it from becoming a life-threatening epidemic. By providing healthcare professionals and patients with easy to use information and tools, we can help make a positive difference to people’s lives and reduce the risk of life-threatening conditions.”

To help combat the rising AF epidemic, GSAAF is encouraging the general public to take action by following three simple steps:

  1. Know the symptoms of AF and the risk factors associated with the condition by visiting https://getsmartaboutAFIB.eu
  2. Carry out pulse checks regularly (either manually or via available technologies such as smartphone apps)
  3. Seek medical advice in case of any irregularities in your heart rhythm and be informed about the different management and treatment options

Alenka Brzulja, Vice President of Cardiovascular & Specialty Solutions EMEA, Johnson & Johnson Medical Devices Companies, comments: “This new millennium epidemic puts a burden on patients, caregivers and healthcare systems. At Biosense Webster, we are passionate about helping patients get access to early detection, diagnosis and the right treatments for AF, and have been for over 20 years. By developing innovative technology solutions, investing in research and publications to advance clinical understanding, and improving education and awareness of AF among clinicians and the general public, we will continue to drive our mission to cure AF”.

All assets including Get Smart About AFIB campaign materials, and the full Atrial Fibrillation Management report and supporting materials, including an infographic, are available at:

[GSAAF website]

[2019 AF Management Report and 2018 Burden of Disease Report and supporting materials]

- ENDS -

NOTES TO EDITORS
About Atrial Fibrillation (AF)
Atrial Fibrillation, sometimes called AF, Afib or Atrial fib, is the most common heart arrhythmia (irregular heart rhythm).26 It occurs when the two upper chambers of the heart (the atria) contract too quickly or in an uncontrolled way.26 The heart rate is controlled by electrical impulses that coordinate the heart’s contractions.27 With AF, these electrical impulses become irregular causing the two chambers of the heart (the atria) to contract in an uncoordinated way. This leads to an irregular and often fast heart rhythm, which can sometime feel like a flutter. When the heart beats erratically, it does not pump blood as efficiently as it should. This may cause you to feel ill or experience other AF symptoms because oxygen isn’t being properly delivered to all parts of your body. AF isn’t life threatening in itself. However, it is important to seek advice from a doctor to access the right treatment not only to control symptoms but also because AF can lead to more serious conditions like AF-related stroke.28 AF is a common health problem with affects 11 million people across Europe35, becoming more common with age. 1 in 4 people over the age of 40 are likely to develop AF during their lifetime.29 The causes of AF are not always clear and can be complex.30,31,32 Possible causes are wide ranging with heart disease, age, family history, high blood pressure, alcohol consumption, obesity and other chronic conditions all contributing risk factors to AF.30,33

About the Johnson & Johnson Medical Devices Companies*
At Johnson & Johnson Medical Devices Companies, we are helping people live their best lives. Building on more than a century of expertise, we tackle pressing healthcare challenges, and take bold steps that lead to new standards of care while improving people’s healthcare experiences. In surgery, orthopaedics, vision and interventional solutions, we are helping to save lives and paving the way to a healthier future for everyone, everywhere.

For more information, visit www.jnjmedicaldevices.com.

*The Johnson & Johnson Medical Devices Companies comprise the surgery, orthopaedics, vision and interventional solutions businesses within Johnson & Johnson’s Medical Devices segment.

About Biosense Webster
Biosense Webster, Inc., part of Johnson & Johnson Medical Devices Companies, is a global leader in the science of diagnosing and treating heart rhythm disorders. The company partners with clinicians to develop innovative technologies that improve the quality of care for arrhythmia patients worldwide. For more information, visit www.biosensewebster.com.

References

  1. Calkins H, Reynolds MR, Spector P, et al. Treatment of atrial fibrillation with antiarrhythmic drugs or radiofrequency ablation: two systematic literature reviews and meta-analyses. Circ Arrhythm Electrophysiol 2009;2(4):349–61.
  2. Pillarisetti J, Lakkireddy D. Atrial fibrillation in Europe: state of the state in disease management! Eur Heart J 2014;35(47):3326–7.
  3. Kuck KH, Lebedev D, Mikaylov E, et al. (2019) Catheter ablation delays progression of atrial fibrillation from paroxysmal to persistent atrial fibrillation [abstract]. Presented at the European Society of Cardiology (ESC) Congress 2019, Paris, France. 31 August 2019.
  4. Mark DB, Anstrom KJ, Sheng S, et al. Effect of Catheter Ablation vs Medical Therapy on Quality of Life Among Patients With Atrial Fibrillation: The CABANA Randomized Clinical Trial. JAMA 2019;321(13):1275–85.
  5. Jaïs P, Cauchemez B, Macle L, et al. Catheter ablation versus antiarrhythmic drugs for atrial fibrillation: the A4 study. Circulation 2008;118(24):2498–505.
  6. Hussein A, Das M, Chaturvedi V, et al. Prospective use of Ablation Index targets improves clinical outcomes following ablation for atrial fibrillation. J Cardiovasc Electrophysiol 2017;28(9):1037–47.
  7. Taghji P, El Haddad M, Phlips T, et al. Evaluation of a Strategy Aiming to Enclose the Pulmonary Veins With Contiguous and Optimized Radiofrequency Lesions in Paroxysmal Atrial Fibrillation: A Pilot Study. JACC Clin Electrophysiol 2018;4(1):99–108.
  8. Phlips T, Taghji P, El Haddad M, et al. Improving procedural and one-year outcome after contact force-guided pulmonary vein isolation: the role of interlesion distance, ablation index, and contact force variability in the 'CLOSE'-protocol. Europace 2018;20(FI_3):f419–27.
  9. Solimene F, Schillaci V, Shopova G, et al. Safety and efficacy of atrial fibrillation ablation guided by Ablation Index module. J Interv Card Electrophysiol 2019;54(1):9–15.
  10. Di Giovanni G, Wauters K, Chierchia GB, et al. One-year follow-up after single procedure Cryoballoon ablation: a comparison between the first and second generation balloon. J Cardiovasc Electrophysiol 2014;25(8):834–9.
  11. Jourda F, Providencia R, Marijon E, et al. Contact-force guided radiofrequency vs. second-generation balloon cryotherapy for pulmonary vein isolation in patients with paroxysmal atrial fibrillation-a prospective evaluation. Europace 2015;17(2):225–31.
  12. Lemes C, Wissner E, Lin T, et al. One-year clinical outcome after pulmonary vein isolation in persistent atrial fibrillation using the second-generation 28 mm cryoballoon: a retrospective analysis. Europace 2016;18(2):201–5.
  13. Guhl EN, Siddoway D, Adelstein E, et al. Efficacy of Cryoballoon Pulmonary Vein Isolation in Patients With Persistent Atrial Fibrillation. J Cardiovasc Electrophysiol 2016;27(4):423–7.
  14. Irfan G, de Asmundis C, Mugnai G, et al. One-year follow-up after second-generation cryoballoon ablation for atrial fibrillation in a large cohort of patients: a single-centre experience. Europace 2016;18(7):987–93.
  15. Boveda S, Metzner A, Nguyen DQ, et al. Single-Procedure Outcomes and Quality-of-Life Improvement 12 Months Post-Cryoballoon Ablation in Persistent Atrial Fibrillation: Results From the Multicenter CRYO4PERSISTENT AF Trial. JACC Clin Electrophysiol 2018;4(11):1440–7.
  16. Packer DL, Mark DB, Robb RA, et al. Effect of Catheter Ablation vs Antiarrhythmic Drug Therapy on Mortality, Stroke, Bleeding, and Cardiac Arrest Among Patients With Atrial Fibrillation: The CABANA Randomized Clinical Trial. JAMA 2019;321(13):1261–74.
  17. Noseworthy PA, Gersh BJ, Kent DM, et al. Atrial fibrillation ablation in practice: assessing CABANA generalizability. Eur Heart J 2019;40(16):1257–64.
  18. Samuel M, Avgil Tsadok M, et al. Catheter ablation for the treatment of atrial fibrillation is associated with a reduction in health care resource utilization. J Cardiovasc Electrophysiol 2017;28(7):733–41.
  19. Weerasooriya R, Jais P, Le Heuzey JY, et al. Cost analysis of catheter ablation for paroxysmal atrial fibrillation. Pacing Clin Electrophysiol 2003;26(1 Pt 2):292–4.
  20. Ball J, Carrington MJ, McMurray JJ, Stewart S. Atrial fibrillation: profile and burden of an evolving epidemic in the 21st century. Int J Cardiol 2013;167(5):1807–24.
  21. United Nations DESA/Population Division. World Population Prospects: The 2019 Revision. Ten Key Findings. Available at https://population.un.org/wpp/Publications/Files/WPP2019_10KeyFindings.pdf. (last accessed October 2019).
  22. Rahman F, Kwan GF, Benjamin EJ. Global epidemiology of atrial fibrillation. Nat Rev Cardiol 2014;11(11):639–54.
  23. Rienstra M, Lubitz SA, Mahida S, et al. Symptoms and functional status of patients with atrial fibrillation: state of the art and future research opportunities. Circulation 2012;125(23):2933–43.
  24. Boriani G, Laroche C, Diemberger I, et al. Asymptomatic atrial fibrillation: clinical correlates, management, and outcomes in the EORP-AF Pilot General Registry. Am J Med 2015;128(5):509–18. e502.
  25. Mairesse GH, Moran P, Van Gelder IC, et al. Screening for atrial fibrillation: a European Heart Rhythm Association (EHRA) consensus document endorsed by the Heart Rhythm Society (HRS), Asia Pacific Heart Rhythm Society (APHRS), and Sociedad Latinoamericana de Estimulación Cardíaca y Electrofisiología (SOLAECE). Europace 2017;19(10):1589–162.
  26. Iaizzo PA. Handbook of Cardiac Anatomy, Physiology, and Devices. 3rd ed. Springer International Publishing; 2015.
  27. Waktare EP. Atrial Fibrillation. Circulation 2002;106:14–16.
  28. Odutayo A, Wong CX, Hsiao AJ, et al. Atrial fibrillation and risks of cardiovascular disease, renal disease, and death: systematic review and meta‐analysis. BMJ 2016;354:i4482.
  29. Lloyd-Jones DM, Wang TJ, Leip EP, et al. Lifetime risk for development of atrial fibrillation: the Framingham Heart Study. Circulation 2004;110(9):1042–6.
  30. Kirchhof P, Benussi S, Kotecha D, et al. 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. Eur Heart J 2016;37(38):2893–962.
  31. Cedars-Sinai. Atrial Fibrilation. Available at https://www.cedars-sinai.org/health-library/diseases-and-conditions/a/atrial-fibrillation.html. (last accessed October 2019).
  32. Naser N, Dilic M, Durak A, et al. The Impact of Risk Factors and Comorbidities on The Incidence of Atrial Fibrillation. Mater Sociomed 2017;29(4):231–6.
  33. Lip GY, Laroche C, Ioachim PM, et al. Prognosis and treatment of atrial fibrillation patients by European cardiologists: one year follow-up of the EURObservational Research Programme-Atrial Fibrillation General Registry Pilot Phase (EORP-AF Pilot registry). Eur Heart J 2014;35(47):3365–76.
  34. Zoni‐Berisso M, Lercari F, Carazza T, Domenicucci S (2014) Epidemiology of atrial fibrillation: European perspective. Clin Epidemiol 2014;(6)213-220.
  35. Global Burden of Disease Collaborative Network (2016) Global Burden of Disease Study 2016 (GBD 2016) Results. Seattle, United States: Institute for Health Metrics and Evaluation (IHME), 2017.

© Johnson & Johnson Medical NV/SA 2019

127176-191106

Contact information

Céline Fontaine
cfontai1@its.jnj.com
+33 (0)6 28 60 45 41

About Business Wire

For more than 50 years, Business Wire has been the global leader in press release distribution and regulatory disclosure.

Subscribe to releases from Business Wire

Subscribe to all the latest releases from Business Wire by registering your e-mail address below. You can unsubscribe at any time.

Latest releases from Business Wire

HCL Technologies Honors Global Goodwill Champions at the 2020 World Economic Forum in Davos24.1.2020 12:47:00 EETPress release

HCL Technologies (HCL), a leading global technology company, today presented its Wave Maker Awards 2020, commemorating global goodwill champions from around the world. The award ceremony, which was held at the HCL Pavilion in Davos, celebrated organizations and individuals passionately committed to such noble causes as diversity & inclusion, education & community upliftment, environment & sustainability, and technology for change. Special guest at the awards was Australian cricket legend Glenn McGrath, who is also founder of the McGrath Foundation, which provides support for Australian women diagnosed with breast cancer and their families. The award recipients were; Lois Auta, Founder and Executive Director of Cedar Seed Foundation, which supports persons with disabilities to participate in all aspects of life; Chido Govera, Founder and Director of The Future of Hope Foundation (TFoHF), which supports marginal and vulnerable members of society through entrepreneurial and self-developme

Ipsen’s palovarotene clinical program in fibrodysplasia ossificans progressiva reaches prespecified interim analysis futility criteria24.1.2020 09:00:00 EETPress release

Regulatory News: Ipsen (Euronext: IPN; ADR: IPSEY) today announced the decision to pause dosing patients in the global Phase III (PVO-1A-301) study designed to evaluate the efficacy and safety of palovarotene in patients with fibrodysplasia ossificans progressiva (FOP), as well as the ongoing Phase II (PVO-1A-202/204) extension studies. In both the Phase III and Phase II extension studies, palovarotene is dosed both chronically (daily) and episodically (during flare-ups). The decision to pause dosing patients in the trial is based on results of a futility analysis reviewed by the Independent Data Monitoring Committee (IDMC) as part of the prespecified interim analysis. The results of a futility analysis indicated that the Phase III FOP trial was unlikely to meet its primary efficacy endpoint (annualized change in new HO volume as compared with Natural History Studyi) upon completion. Despite the results of the prespecified interim analysis, signals of encouraging therapeutic activity w

Amazentis Announces the Launch of Timeline™ Cellular Nutrition at the World Economic Forum in Davos23.1.2020 23:56:00 EETPress release

Amazentis announces the debut of Timeline, a next generation nutrition product designed to promote healthy aging, as part of the Swiss Food & Nutrition Valley in the House of Switzerland at the World Economic Forum in Davos, Switzerland. Given the increase in the aging population globally -- according to a 2019 Deutsche Bank study, there are more people on Earth older than sixty five than younger than five for the first time -- it is imperative for consumers to take proactive measures to maintain a high quality of life, for as long as they live. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20200123005820/en/ (Photo: Business Wire) Timeline contains the proprietary nutrient Mitopure™, a highly pure form of Urolithin A. After a decade of rigorous research by leading scientists around the world, Mitopure has been shown to help counter age-associated cellular and muscular decline by revitalizing the mitochondria, the powerplants

Lionbridge Names Corinne Saunders as Managing Director, EMEA23.1.2020 21:00:00 EETPress release

Today, Lionbridge, a global leader in localization and data training services, announced that former Wolters Kluwer executive Corinne Saunders has joined the company as managing director of EMEA. Lionbridge currently has 51 offices in 26 countries around the world; Saunders will oversee EMEA sales, account management, and marketing operations. “Europe represents a large portion of our overall business and will continue to be a growth area for our AI and localization businesses. I am very happy that Corinne is coming onboard to lead our efforts across EMEA,” says Lionbridge Chief Executive Officer John Fennelly. “Throughout her career, she’s shown an exceptional ability for driving innovation and understanding customer needs.” While at Wolters Kluwer, Saunders served as chief executive officer for emerging and developing markets. Saunders will work from Brussels, Belgium. About Lionbridge Lionbridge partners with brands to break barriers and build bridges all over the world. For more th

President Bill Clinton to Keynote 2020 World Patient Safety, Science & Technology Summit23.1.2020 20:34:00 EETPress release

President Bill Clinton, the 42nd President of the United States, will be the closing keynote speaker at the Patient Safety Movement Foundation’s 2020 World Patient Safety, Science & Technology Summit. The 8th annual Summit will be held in Huntington Beach, California, beginning with a Pre-Summit Symposium on Thursday, March 5th. At the 2020 Summit, hospital leaders, medical and information technology innovators, patient advocates, policy makers and government officials collaborate and discuss best practices solutions to eliminate preventable patient deaths in hospitals around the world. The event is co-convened with the International Society for Quality in Health Care (ISQua), the American Society of Anesthesiologists and the European Society of Anaesthesiology. The 2020 Summit is scheduled for March 5 – 7th, 2020, at the Waterfront Beach Resort in Huntington Beach, California. For more information about the 2020 World Patient Safety, Science & Technology Summit, visit http://patientsa

Covantis initiative announces technology partner - ConsenSys23.1.2020 18:00:00 EETPress release

The founding members of the Covantis initiative, which aims to modernize global trade operations, have announced the selection of ConsenSys, a market-leading Ethereum blockchain technology company, as the lead technology partner to develop its transformative platform. “The founders set up a robust selection process, including a two week hackathon, to ensure that we chose the right technology partner to meet our industry’s needs,” said Stefano Rettore, independent advisor to the project. “ConsenSys presented prototypes that demonstrated excellence in its field and has a track record of using blockchain technology to digitize processes in the commodity trade finance industry. We are confident this partnership will allow us to build a first-class product, centered around unparalleled functionality, security and privacy.” ConsenSys will leverage its enterprise-ready blockchain solutions and services, including PegaSys Orchestrate, Kaleido and MythX to build the blockchain network on Ethere

In our pressroom you can read all our latest releases, find our press contacts, images, documents and other relevant information about us.

Visit our pressroom