Business Wire

Boehringer Ingelheim Acquires AMAL Therapeutics, Significantly Enriching Its Cancer Immunology Portfolio with Novel Cancer Vaccines Platform

Share

Boehringer Ingelheim today announced its acquisition of all shares of AMAL Therapeutics SA, a private Swiss biotechnology company focused on cancer immunotherapy and advancing first-in-class therapeutic cancer vaccines derived from its technology platform KISIMA. AMAL’s lead vaccine ATP128 is currently developed for stage IV colorectal cancer and is slated to begin first-in-human trials later this month. Boehringer Ingelheim plans to develop new therapies by combining assets from its cancer immunology portfolio with AMAL’s proprietary KISIMA immunization platform.

“Acquiring AMAL is part of Boehringer Ingelheim’s long-term strategy to enhance our existing position as an innovator of novel cancer therapies, including immuno-oncology treatments, which leverage cutting-edge scientific discoveries and their applications,” said Michel Pairet, member of Boehringer Ingelheim’s Board of Managing Directors with responsibility for the company’s Innovation Unit. “We want to pioneer new paradigms of biology-based care for cancer patients, and the technologies and expertise developed at AMAL are critical to our efforts.”

The total transaction could amount up to EUR 325 million, and is comprised of an upfront payment as well as contingent clinical, development and regulatory milestones plus up to EUR 100 million if certain commercial milestones are hit.

“I am extremely proud of the hard work of AMAL’s entire team, which is validated by this acquisition, and very excited to further develop the KISIMA technology platform within Boehringer Ingelheim,” said Madiha Derouazi, Ph.D., Founder and Chief Executive Officer of AMAL Therapeutics. “Our new relationship with Boehringer Ingelheim will enable us to realize the full potential of our KISIMA platform to fight solid cancers while preserving AMAL’s approach to biotechnology research and our scientific and academic networks. Moreover, sharing resources and capabilities in clinical development will greatly help us to move ATP128 and other assets forward.”

Boehringer Ingelheim’s Cancer Immunology group is built to discover therapies that engage triggering of immune responses against non-inflamed, “cold” tumors, which represent a large group of cancer types refractory to many treatments, including checkpoint inhibitor drugs. Immune targeting of cold tumors is a particular challenge. AMAL’s KISIMA vaccine technology, designed to stimulate potent immune responses, is a promising therapeutic option for patients with these type of cancers.

The AMAL acquisition, along with that of the 2018 acquisition of Vira Therapeutics (Vira-T) and in-license of OSE Immunotherapeutics’ SIRP-alpha targeting antibody, significantly strengthens Boehringer Ingelheim’s strategic focus on immune cell-directed therapies. By combining its world-class in-house research and development with that of highly innovative biotechnology companies, Boehringer Ingelheim is developing innovative immuno-oncology therapies and accelerating the delivery of the next-generation of cancer treatments.

AMAL is headquartered on the medical campus of the University of Geneva, from which it was spun-out in 2012, with financial backing from a syndicate of both corporate and institutional investors, including the Boehringer Ingelheim Venture Fund and High-Tech Gründerfonds as the initial seed investors. Additional investments were provided by VI Partners, Helsinn Investment Fund, BioMed Partners and Schroder Adveq. AMAL’s technology platform and derived products are protected by a broad portfolio of patents and licenses.

KISIMA
Unlike prophylactic vaccines that immunize a patient to prevent an infection before it occurs, therapeutic vaccines combat existing diseases. Anti-cancer therapeutic vaccines carry antigens, pieces of protein that also are in tumors. By presenting antigens to the patient’s immune system, a vaccine can prompt tailor-made responses, including activation of killer T cells that target the tumor and can boost memory immunity to reduce the risk of relapse.

AMAL’s proprietary technology platform KISIMA enables the assembly of three functional components into one patented fusion protein used as a vaccine: First, a proprietary cell-penetrating peptide for antigen delivery; second, a proprietary toll-like receptor (TLR) peptide agonist as an adjuvant, and third, a multi-antigenic cargo that can be tailored for specific indications.

Please click on the link for Notes to Editors and References:
http://www.boehringer-ingelheim.com/press-release/acquisition-amal-therapeutics

Contact information

Media Contacts:
Boehringer Ingelheim
Linda Ruckel
Associate Director, Media and Corporate Reputation
Boehringer Ingelheim U.S.
Media + PR
P: + 203-791-6672
linda.ruckel@boehringer-ingelheim.com

Dr. Reinhard Malin
Head of Communications Innovation Unit
Boehringer Ingelheim Corporate Center GmbH
Media + PR
press@boehringer-ingelheim.com
P: +49 6132 77-90815
M: + 49 151 150 20 690
www.boehringer-ingelheim.com

AMAL Therapeutics SA
Laurence de Schoulepnikoff
Chief Business Officer
Tel: +41 (0) 22 379 46 88 contact@amaltherapeutics.com

Instinctif Partners (for International and English-speaking media)
Dr. Christelle Kerouedan
Tel: +44 (0) 207 457 2020 amaltherapeutics@instinctif.com

About Business Wire

For more than 50 years, Business Wire has been the global leader in press release distribution and regulatory disclosure.

Subscribe to releases from Business Wire

Subscribe to all the latest releases from Business Wire by registering your e-mail address below. You can unsubscribe at any time.

Latest releases from Business Wire

Temenos and Google Cloud Announce Global Strategic Partnership to Accelerate Banks’ Digital Transformation in the Cloud29.1.2020 12:05:00 EETPress release

Temenos (SIX: TEMN), the banking software company, and Google Cloud today announced a global, strategic partnership to help financial services organizations run mission-critical banking software and applications on Google Cloud, create profitable business models, and improve and differentiate their customer experiences. The two companies began collaborating in 2019 to integrate Temenos cloud-native, cloud-agnostic software into Google Cloud and have demonstrated success with joint banking customers in Europe and Asia. Under this expanded partnership, Temenos’ full suite of banking software and applications will now be available on Google Cloud, and the two companies will help banks go to market faster, open up new business models, and achieve tangible business benefits. More than 3,000 financial services institutions around the world leverage Temenos’ modern, cloud-native and API-first technology. As a part of this strategic partnership, banks can run Temenos’ applications in Google Cl

IVG: Huge Win for The Vape Industry29.1.2020 12:00:00 EETPress release

Two massive wins for IVG (I Vape Great) is the reason for their celebration. Over the last 4 years, IVG has sold 14 million bottles of e-liquid, the global e-liquid firm based in Preston has been selected to sell their products in 41 airport terminals and in 22 airports across the UK. After going head to head with some of the biggest names in the vape industry IVG has also been crowned UK’s Best Brand of 2019 at the Ecigclick Awards , which saw a record amount of voters. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20200129005020/en/ IVG in UK Duty Free and Winner of 'Best UK Brand' (Photo: Business Wire) “We are delighted to have won this award and to have our products entering airports across the United Kingdom. We think this is a fantastic opportunity, not only for vapers but also for smokers wanting to switch to vaping worldwide” – Ahsan Bawa CEO of IVG Premium E-Liquids. Which IVG Products Will Be Available in The Airpo

nCipher Introduces Cloud-first Architecture, Bringing Security and Control to Public and Private Clouds29.1.2020 11:00:00 EETPress release

nCipher Security, an Entrust Datacard company and provider of trust, integrity and control for business critical information and applications, announces two new additions to its nShield® hardware security module (HSM) portfolio – nShield Web Services Option Pack and nShield Container Option Pack – that make it simpler to deploy applications in the cloud and bring greater security and control to public and private clouds. nShield Web Services Option Pack simplifies deployment for cloud-first data centres. nShield Web Services Option Pack provides a REST API between applications requiring cryptographic key and data protection services and nShield HSMs, enabling seamless application deployment underpinned by high-assurance nShield HSMs, which can dynamically scale to meet the needs of cloud-ready data centers. Customers can also use their own load balancing appliances to handle the HSM workload, simplifying the HSM deployment and configuration, and ensuring the best utilization of their H

Denenchofufutaba Gakuen, NTT Group Start a Joint Study to Create Smart Campus Solutions29.1.2020 10:32:00 EETPress release

NTT Group (Nippon Telegraph and Telephone Corporation (Hereinafter, NTT), NTT DATA Corporation, NTT COMWARE Corporation, NTT Communications Corporation, NTT Ltd., Nippon Telegraph and Telephone East Corporation (Hereinafter, NTT East)) will begin a joint study with Denenchofufutaba Gakuen in order to develop smart campus solutions that will provide safety and security at schools. NTT Group implements technology of public safety solution that will draw on the proven implementation for the City of Las Vegas. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20200128005916/en/ Solution Overview (Graphic: Business Wire) 1. Background In recent years, there have been several crimes and incidents involving students in school facilities, and resulting in requests to improve safety measures in addition to crime prevention activities by national and local governments. Furthermore, with the introduction of new educational guidelines, the w

Panasonic Develops High-Power Blue WBC Technology to Revolutionize DDL Applications on Microfabrication29.1.2020 09:11:00 EETPress release

On January 29, 2020, Panasonic Corporation announced it has succeeded in demonstrating the world's highest brightness blue laser. This has been achieved by using the wavelength beam combining (WBC) technology [1] on a direct diode laser (DDL) to produce a high quality output beam [2]. With this technology, power scaling is enabled while maintaining the beam quality by simply increasing the number of laser sources. This demonstration opens the door to laser intensities that could be two orders of magnitude higher than conventional blue laser systems. This technology will contribute to the emerging microfabrication processes, whose demand is expected to grow in industrial applications, such as in the automotive industry. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20200128005907/en/ Wavelength Beam Combining (WBC) technology (Graphic: Business Wire) The automotive industry is moving towards “electrification” and “miniaturizat

NTT Group to Launch Asia's First Smart City Proof of Concept Collaborating with Cyberview and Allo in Malaysia29.1.2020 09:00:00 EETPress release

As part of the Japanese Ministry of Internal Affairs and Communications’ FY 2019 project "Research on Smart City Model for Solving Social Problems in Malaysia", based on the smart city initiatives which has been started with the City of Las Vegas, United States, NTT Group (Nippon Telegraph and Telephone Corporation (Hereinafter, NTT), NTT Communications Corporation, NTT Ltd., InfoCom Research, Inc., NTT DATA Corporation, NTT COMWARE Corporation) will conduct Asia's one of the first Smart City Proof of Concept (PoC) in the Cyberjaya area of Malaysia from February 2020, in cooperation with local stakeholders. Through this PoC, NTT Group aims to establish a sustainable business model while verifying the possibility of solving social issues in Asia, utilizing the technologies and know-how accumulated in the smart city field in the United States. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20200128005904/en/ (Graphic: Business W

In our pressroom you can read all our latest releases, find our press contacts, images, documents and other relevant information about us.

Visit our pressroom