Boehringer Ingelheim Expands KRAS Cancer Program with Lupin’s Clinical Stage MEK Inhibitor Compound
4.9.2019 10:00:00 EEST | Business Wire | Press release
Boehringer Ingelheim and Lupin Limited (Lupin) today announced a licensing, development and commercialization agreement for Lupin’s MEK inhibitor compound (LNP3794) as a potential targeted therapy for patients with difficult-to-treat cancers. The partnership aims to develop Lupin’s lead MEK inhibitor compound in combination with one of Boehringer Ingelheim’s innovative KRAS inhibitors for patients with gastrointestinal and lung cancers harboring a broad range of oncogenic KRAS mutations.
“The licensing of Lupin’s novel MEK inhibitor enables us to pair with our innovative KRAS inhibitors to develop new combination treatment concepts providing more effective and durable responses for patients with cancers driven by activated KRAS who currently have limited treatment options available,” said Norbert Kraut, Ph.D., Head of Global Cancer Research at Boehringer Ingelheim. “We believe this collaboration will significantly strengthen our KRAS program. We have developed comprehensive approaches to successfully tackle the oncogenic KRAS–RAF–MEK–ERK pathway from the ground up and this partnership is another key building block in our long-term strategy to bring novel treatments to patients in our quest to defeat intractable cancer types.”
Commenting on the partnership, Nilesh Gupta, Managing Director, Lupin Limited said, “With the success of our second new drug discovery program in oncology, we have made a significant mark in bringing novel treatments to patients. Lupin’s MEK Inhibitor program successfully cleared early clinical stages, demonstrating our capabilities in delivering world class innovation. We are proud of the achievements of our team and the capabilities we have built which enable us to further our new drug discovery program. We are delighted to partner with Boehringer Ingelheim in developing treatments that will truly benefit patients in need”.
Dr. Raj Kamboj, President of Lupin’s Novel Drug Discovery and Development (NDDD) stated, “The success of our second NDDD program in Oncology has added to our confidence in bringing highly differentiated and best-in-class innovation from India for patients globally. Carrying forward our founder, Dr. Desh Bandhu Gupta’s dream in shaping true innovation, we have delivered a novel treatment from conceptualization to clinical stage development with promising results that can be a potential combination treatment for precision oncology.”
The collaboration has a strategic goal to focus on patients with gastrointestinal or lung cancers defined by KRAS mutations, sub-populations that currently need more effective therapeutic options. KRAS mutations occur in 1 in 7 of all human metastatic cancers making it the most frequently mutated cancer-causing gene, with mutation rates of more than 90 percent in pancreatic cancers, more than 40 percent in colorectal cancers and more than 30 percent in lung adenocarcinomas. Preclinical data has shown that the combination of Boehringer Ingelheim’s novel KRAS inhibitors with MEK inhibitors results in increased anti-tumor activity based on their complementary mechanisms of action in keeping KRAS-driven cancers in check.
Lupin’s MEK inhibitors developed as part of its oncology pipeline have shown pre-clinical activity as a single agent as well as in combination. Furthermore, they have also shown early clinical benefit in a small subset of patients. Lupin’s Novel Drug Discovery and Development team is focused on building a pipeline of highly differentiated and innovative new chemical entities in the therapeutic areas of oncology, immunology and metabolic disorders. Lupin’s NDDD activities were started with the vision to use cutting-edge research in bringing novel molecules that address unmet medical needs in multiple therapeutic areas to market globally.
Lupin will receive an upfront payment of $20 million and potential additional payments for successful achievement of defined clinical, regulatory and commercial milestones for a total deal value of more than $700 million. Additionally, Lupin will be entitled to receive double-digit royalties on the sales of the product.
Please click on the following link for ‘Notes to Editors’:
http://www.boehringer-ingelheim.com/press-release/expansion-kras-cancer-program-mek-inhibitor
To view this piece of content from cts.businesswire.com, please give your consent at the top of this page.
View source version on businesswire.com: https://www.businesswire.com/news/home/20190904005377/en/
Contact information
Boehringer Ingelheim
Dr. Reinhard Malin
Head of Communications Innovation Unit
Boehringer Ingelheim Corporate Center GmbH
Media + PR
P: +49 6132 77-90815
reinhard.malin@boehringer-ingelheim.com
Linda Ruckel
Associate Director, Media and Corporate Reputation
Boehringer Ingelheim U.S.
Media + PR
P: + 203-791-6672
linda.ruckel@boehringer-ingelheim.com
LUPIN Limited
Pooja Thakran
VP – Corporate Communications
Email: poojathakran@lupin.com
Ph: +91-22-66402531 / 8291013225
Arvind Bothra
Head – Investor Relations
Email: arvindbothra@lupin.com
Ph: +91-22-66408237
About Business Wire
For more than 50 years, Business Wire has been the global leader in press release distribution and regulatory disclosure.
Subscribe to releases from Business Wire
Subscribe to all the latest releases from Business Wire by registering your e-mail address below. You can unsubscribe at any time.
Latest releases from Business Wire
Lenovo Tab Plus Gen 2 Delivers a Smarter, More Immersive Entertainment Experience16.6.2026 14:01:00 EEST | Press release
Today Lenovo™ introduced the Tab Plus Gen 2, the next generation of its tablet created for the increasingly fluid ways people move between media consumption, multitasking, and shared experiences. With upgrades spanning audio, visuals, versatility, and intelligent features, it expands the role of the tablet across a broader range of activities and environments. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20260616736263/en/ “Entertainment today isn’t tied to a single place or routine,” said Tony Chen, Vice President of Tablets, Intelligent Devices Group, Lenovo. “People are moving seamlessly between work, travel, and downtime, and they expect their devices to move just as naturally with them. With the Lenovo Tab Plus Gen 2, we created a device that keeps up with that rhythm, giving users the freedom to enjoy content on their terms.” Sound That Fills the Space Whether watching movies, streaming shows, or listening to music, us
Aurora Solar Adds Integrated Storage Modeling to HelioScope, Uniting Commercial Solar Design, Storage, and Financial Analysis in One Solution16.6.2026 13:00:00 EEST | Press release
Aurora Solar, the leading global platform for solar sales and design, today announced the addition of integrated storage modeling to HelioScope. This new feature empowers users to size storage, model performance, and run the financial case in the same place they design the system. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20260616352623/en/ A preview of how storage modeling is integrated into the design workflow in HelioScope for fast iteration and optimization of solar-plus-storage projects What once required three tools — design, storage modeling, financials — now happens in one solution, from layout to a lender-ready output developers can take straight into financing. When a client asks what a bigger battery does to the economics, the answer takes minutes, not days. "The solar market is being tested right now, and the companies that come out ahead will be the ones that make their teams faster and their numbers more def
Dubai Chambers Organises Open Dialogue in London to Showcase Dubai’s Competitive Advantages as a Global Business Hub16.6.2026 12:25:00 EEST | Press release
Dubai Chambers organised an open dialogue in London in cooperation with the London Chamber of Commerce and Industry (LCCI) aimed at showcasing Dubai’s competitive advantages as a global business hub to a group of leading British investors. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20260616827193/en/ H.E. Mohammad Ali Rashed Lootah addresses the audience during the event (Photo: AETOSWire) The event was attended by His Excellency Mohammad Ali Rashed Lootah, President and CEO of Dubai Chambers, together with UK business leaders. Discussions highlighted the key investment opportunities Dubai offers across diverse sectors, as well as the city’s advantages as a hub for the expansion of British companies in the region and globally. The session also outlined the comprehensive support provided by Dubai Chambers to UK investors to ensure the smooth establishment and growth of their businesses in Dubai. The discussions explored how
NIQ and Unlimitail Collaborate to Deliver the Next Generation of Omnichannel Retail Media Insights & Measurement Across Retailers and Countries16.6.2026 12:00:00 EEST | Press release
Retail media investment is accelerating globally, with 67% of CMOs planning to increase spending on retail media networks (RMNs) in 2026. Yet only 53% believe today's RMNs provide adequate measurement and attribution capabilities, highlighting a critical gap in proving true business impact across retailers and markets.* Today, NIQ (NYSE: NIQ), a leading consumer intelligence company, and Unlimitail, a leading retail media network, announced a strategic collaboration designed to help brands and retailers unlock a new era of retail media accountability through advanced measurement, consumer insights, interoperable data infrastructure, and AI-powered analytics. This collaboration will combine Unlimitail's extensive retail media network, which spans 21 countries, 35 retailers, more than 120 retailer websites, and over 250 million loyalty cardholders, with NIQ's industry-leading measurement, analytics, and consumer intelligence capabilities. Together, the companies will help advertisers mov
Thredd Expands Partnership with ID DISTRIBUTION to Power Next Phase of Employee Benefits and Expense Innovation16.6.2026 12:00:00 EEST | Press release
Thredd, the AI-first issuer processing platform, today announced an expanded partnership with ID DISTRIBUTIONthrough its flagship program Vaziva, a leading employee benefits and payments platform, to support its growth beyond consumer payments, into corporate payments, as well as their international expansion. Thredd has worked with ID DISTRIBUTIONsince 2020, supporting the company’s consumer offering in France with physical and digital card issuing and payments processing capabilities. Its Vaziva card program enables companies to digitally manage and distribute multiple types of employee benefits through a single prepaid Mastercard-branded card experience. The program supports convenient, secure card usage for employees to access and use benefits across categories including lunch, gifts, culture, holidays, and travel. With more employers seeking simpler, more digital ways to manage employee benefits and purchasing, IDD is building on its existing consumer card programme to launch a ne
In our pressroom you can read all our latest releases, find our press contacts, images, documents and other relevant information about us.
Visit our pressroom