Business Wire

Cell Therapy Tools for Cartilage Repair From Osteoarthritic Knee Joint of Elderly

Share

A break through feat of growing pluripotency expressing cells from osteoarthritis (OA) affected cartilage tissue of knee joints of elderly has been reported by orthopedicians and cell culture experts led by Dr Shojiro Katoh, President, Edogawa Hospital. OA affects, knee joints of millions globally and those with severe disease, undergo Total Knee Arthroplasty (TKA), in which damaged cartilage is replaced with artificial knee prosthesis. Dr Katoh, during TKA surgery, took portions of the damaged tissue, which otherwise is discarded, isolated chondrocyte cells in tissue engineering lab, and could culture them as fully reorganized healthy cartilage tissue, expressing biomarkers relevant to pluripotency.

This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20200617005880/en/

To view this piece of content from mms.businesswire.com, please give your consent at the top of this page.

"Pluripotency expressing cells grown from osteoarthritis affected knee joint, open doors to a spectrum of novel solutions to address cartilage damage," says Dr. Shojiro Katoh, President, Edogawa Hospital, Tokyo, Japan. (Photo: Business Wire)

Cartilage of the knee joint acts as a cushion between bones of the thigh and leg and absorbs the body weight. When cartilage is damaged due to sports injury, trauma or wear and tear, it causes joint pain and disability. In early stage of the disease, Autologous Chondrocyte Implantation (ACI) or Matrix Assisted Chondrocyte Implantation (MACI) are practiced. Such cell therapies use patient’s own cartilage cells, harvested from healthy, non-weight bearing area, grown in lab, and transplanted to replace the damaged tissue, to restore functionality.

"This could probably be the world’s first report of Osteoarthritis tissue, yielding cells expressing pluripotency markers," said Dr. Katoh, citing their publication in Regenerative Therapy Journal (https://www.sciencedirect.com/science/article/pii/S2352320420300274), also presented in the 19th Japanese society for regenerative medicine meeting. "Our technique may help utilize OA affected cartilage, discarded as biomedical waste, as a source of tools of cell therapies viz., cells, cell secreted growth factors, and exosomes to repair cartilage defects in regenerative medicine," he added.

Edogawa hospital, located in eastern Tokyo, has many senior citizens. "Contrary to the age-old belief that Wisdom is the strength of elders, this research finding has made me humble, to learn about nature’s hidden strength in their physical intricacies too, fueling our enthusiasm," said Dr Katoh adding a philosophical humility to his accomplishment. His Edogawa Evolutionary Lab of Science (EELS), having confirmed hyaline phenotype is now evaluating miRNA-140 and Hyaluronan expression of chondrocytes.

This technology has a potential to solve cartilage damage of approximately 12 million people annually worldwide, according to JBM Inc, and GN Corporation, co-applicants to a patent and research partners to EELS.

To view this piece of content from cts.businesswire.com, please give your consent at the top of this page.

Contact information

Samuel JK Abraham
GN Corporation
info@gncorporation.com

About Business Wire

For more than 50 years, Business Wire has been the global leader in press release distribution and regulatory disclosure.

Subscribe to releases from Business Wire

Subscribe to all the latest releases from Business Wire by registering your e-mail address below. You can unsubscribe at any time.

Latest releases from Business Wire

African Carbon Origination to Explode via Carbon Trade eXchange (CTX)1.12.2022 15:34:00 EET | Press release

Carbon Trade Exchange Limited (CTX) and Global Environment Markets (GEM) have signed a pan-African Ambassador Agreement with Ecologistics Integrated Services Limited (Ecologistics). This Agreement was forged at COP27 in Egypt to meet an overwhelming demand for Africa to engage in supporting the Carbon Markets. CTX, GEM and Ecologistics will work together to expand GEM’s National Carbon Meta Registries aimed at supporting the development of Carbon Markets, ITMO, Voluntary Markets in Africa, and to produce Carbon Credits to be available for global trading via an electronic interface with CTX. Leveraging GEM’s “Technology Infrastructure for the Future of our Planet” provides the opportunity for governments, as Paris Agreement signatories, to support their commitments and trade credits under Article 6. Ecologistics is a leading global climate change investment and sustainable development firm with headquarters in Abuja, Nigeria, The firm is also the convener of the Nigeria Climate Change I

All New Bacardi Gift Packs Go 100% Plastic-Free1.12.2022 15:00:00 EET | Press release

Family-owned Bacardi has extra reason to celebrate this holiday season as it reaches a milestone in its mission to remove 100% of the single-use plastic from its gifting range by the end of 2023. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20221201005320/en/ All New Bacardi Gift Packs Are Plastic Free In Time For Holiday Season (Photo: Business Wire) From this month, ready for the busy festive period, all new gift packs in the Bacardi portfolio – including BACARDÍ® Reserva Ocho rum, GREY GOOSE® vodka, BOMBAY SAPPHIRE® Premier Cru, MARTINI® vermouth, PATRÓN® tequila and DEWAR’S® 12 Year Old Blended Scotch whisky – are now 100% plastic-free. This significant step will see Bacardi remove almost 275 tons of single-use plastic used annually and has been achieved through innovative new designs that remove plastic or replace it with a sustainably sourced alternative. As well as using cardboard certified by the Forest Stewardship C

NuScale Power Signs Research Collaboration Agreement for Clean Hydrogen Production1.12.2022 14:50:00 EET | Press release

NuScale Power, LLC (NuScale) along with Shell Global Solutions (Shell) and industry participants will develop and assess a concept for an economically optimized Integrated Energy System (IES) for hydrogen production using electricity and process heat from a NuScale VOYGR™ small modular reactor (SMR) power plant. The project entitled, “Development and Demonstration of a Concept for an Economically Optimized IES,” will be completed in two phases. Additional research participants include Idaho National Laboratory, Utah Associated Municipal Power Systems (UAMPS), Fuel Cell Energy, FPoliSolutions, and GSE Solutions. NuScale’s flexible SMR technology holds the potential to balance and stabilize power grids dominated by renewable energies through hydrogen production. Energy markets present reliability concerns at times when energy demand is high and renewable energy production is low. In these markets, hydrogen would be used as an end-product or as a stored energy source to be processed throu

Velodyne Lidar Launches Vella Family of Software Products1.12.2022 14:48:00 EET | Press release

Velodyne Lidar, Inc. (Nasdaq: VLDR, VLDRW) today announced the beta launch of its Vella family of software products. Vella enables Velodyne’s customers to accelerate development of lidar-based vision solutions for autonomous applications. Using the online platform Vella Portal, Velodyne’s sensor customers can easily access Vella’s software offerings, which include Vella Go for lidar sensor management, Vella Perception for application development and Vella Cloud Services for artificial intelligence (AI) capabilities. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20221201005415/en/ Velodyne Lidar's Vella family of software products includes sensor management, calibration, perception and cloud software offerings. Image credit: Velodyne Lidar, Inc. “Velodyne’s customers use lidar to advance autonomy in a multitude of markets, from transportation to infrastructure, industrial, robotics and more,” said Dr. Ted Tewksbury, CEO, Velod

Energy Globe Foundation Presents Solutions for Our Environment1.12.2022 14:24:00 EET | Press release

In an extremely exciting ceremony on November 30 in Vienna at the world's most important environmental award, the world winners for sustainability were chosen in the 5 categories, Earth, Fire, Water, Air and Youth. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20221128005435/en/ From left to right - Freya Burton (LanzaTech – Winner Category AIR from China), Sarah Alexander (nurture.farm, AgTech Startup – Winner Category EARTH from India), Karl Boyce (ARC Power – Winner Category FIRE from Rwanda), Roberta Dixon-Valk (Take 3 for the Sea – Winner Category YOUTH from Australia), Rodrigo Oliveira (Eco Panplas – Winner Category WATER from Brazil) (Photo: Business Wire) For more than 20 years, the Energy Globes have been awarded annually. In total, over 30,000 sustainable projects have been submitted, proposing innovative solutions to environmental problems. This was confirmed by high-ranking experts in a panel discussion before the

In our pressroom you can read all our latest releases, find our press contacts, images, documents and other relevant information about us.

Visit our pressroom