LG Chem Life Sciences Announces First Participant Dosed in First-in-Human Study of SSAO Inhibitor LG00303174 in the United States
23.2.2021 01:33:00 EET | Business Wire | Press release
LG Chem Life Sciences (“LG Chem”) today announced the first healthy adult volunteer has been safely dosed in the phase I study of LG00303174 being run in the US.
LG Chem licensed LG00303174 (TT-01025) from TransThera Biosciences Co. Ltd. (“TransThera”), a clinical-stage biotechnology company based in Nanjing, China. LG Chem had entered into an exclusive license agreement with TransThera in August 2020 to research, develop, manufacture, and commercialize LG00303174 in the world except China and Japan.
LG00303174 is a potential best-in-class novel SSAO/VAP-1 inhibitor, currently being developed for the treatment of chronic inflammatory diseases, including non-alcoholic steatohepatitis (NASH). The phase 1 study is currently being conducted within the U.S. and approximately 64 subjects are expected to be enrolled.
“The commencement of this study is a significant landmark for LG Chem as we are determined to address the clear unmet needs of those with metabolic disease,” said Adam Benson, Director of Clinical Development of LG Chem Life Sciences Innovation Center in Cambridge, MA. “NASH to this day remains an elusive target. We feel strongly that LG00303174 has shown, in pre-clinical models, to have a strong safety profile, and as an oral therapy, has the potential to address a clear need in a disease that is becoming increasingly burdensome to our healthcare system.”
Dr. Frank Wu, CEO of TransThera, commented: “We congratulate LG Chem team on the rapid implementation of FIH trial in the United States, which marks a key milestone for this collaboration program.”
According to Dr. Jeewoong Son, President of LG Chem Life Sciences in Seoul, Korea, the fast and efficient implementation of this phase 1 study “is a testament to our clinical development capabilities of the LG Chem Life Sciences Innovation Center in Cambridge as a center of excellence to enrich and forward our development pipeline.”
About LG Chem Life Sciences
LG Chem Life Sciences is a business division within LG Chem, engaged in the development, manufacturing, as well as commercializing pharmaceutical products globally. LG Chem Life Sciences seeks to expand and make global presence by focusing on key core therapeutic areas of Immunology, Oncology, and Metabolic Diseases (specifically, diabetes and related metabolic diseases). To achieve such, its strategy is to actively pursue global collaboration encompassing from asset-centric to strategic investment and collaboration.
LG Chem Life Sciences Innovation Center: innovation.lgchem.com
About TransThera Biosciences
TransThera Biosciences is a clinical-stage biotechnology company dedicated to developing innovative therapeutics to target diseases with major unmet medical needs via internal research platform and open innovation. TransThera's current portfolio covers therapeutic areas such as oncology, cardiovascular, and inflammatory diseases. For more information, please visit www.transtherabio.com.
To view this piece of content from cts.businesswire.com, please give your consent at the top of this page.
View source version on businesswire.com: https://www.businesswire.com/news/home/20210222005934/en/
Contact information
Media (Jiin Chung): media.cbl@lgchem.com
General Inquiries: contact.cbl@lgchem.com
Partners: partners.cbl@lgchem.com
About Business Wire
For more than 50 years, Business Wire has been the global leader in press release distribution and regulatory disclosure.
Subscribe to releases from Business Wire
Subscribe to all the latest releases from Business Wire by registering your e-mail address below. You can unsubscribe at any time.
Latest releases from Business Wire
ŌURA Named Official Wearable of Team Finland23.2.2026 10:00:00 EET | Press release
ŌURA, maker of the world’s leading smart ring, Oura Ring, today announced a long-term partnership as the Official Wearable of Team Finland. As the exclusive provider in the category of continuous health and fitness tracking devices, ŌURA will equip Team Finland Olympic athletes with Oura Ring beginning immediately and continuing through the LA28 Olympic Games and the French Alps 2030 Winter Games. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20260223559508/en/ Team Finland delivered a strong showing on the world stage at the Olympic Winter Games Milano Cortina 2026, capturing a total of six Olympic medals across a range of winter sports. During the Games, many Finnish athletes wore Oura Ring to help manage their performance and recovery. The partnership marks the start of a multi-year collaboration focused on supporting athlete preparation, recovery, and overall wellbeing across two Olympic cycles. “At ŌURA, we believe susta
AHS Tower Fully Sold During Development, Generating More Than USD 700 Million23.2.2026 09:55:00 EET | Press release
AHS Properties has confirmed that 100 percent of inventory at AHS Tower has been sold, generating more than USD 700 million in revenue during the development phase, a clear indicator of strong market demand for its flagship commercial project. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20260222540070/en/ AHS Tower Fully Sold During Development on Sheikh Zayed Road (Photo: AETOSWire) Rising 69 storeys above Sheikh Zayed Road, the tower is positioned within minutes of DIFC and the Museum of the Future. Designed by internationally acclaimed architecture firm Killa Design, with interiors by AHS Atelier, it represents a defining step in AHS Properties’ expansion from ultra-luxury residential developments into Grade A commercial real estate. This demand comes amid a year of exceptional business growth in the UAE, with more than 250,000 new companies established in 2025, bringing the total number of operating companies to 1.4 mil
AGCO Power’s Core80 Engine Named Diesel Engine of the Year 202623.2.2026 09:00:00 EET | Press release
Developed and manufactured in Linnavuori, Finland, the engine represents the most advanced technology in AGCO Power’s new Core engine family. The award is among the most respected in the industry and has been recognizing groundbreaking off‑highway powertrain innovations for 20 years. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20260222724310/en/ Powertrain International Editor-in-Chief Fabio Butturi (left) presents the Diesel Engine of the Year 2026 award to AGCO Power Vice President Juha Tervala. Next to them, AGCO Power Project Manager for Engineering Juha-Pekka Asikainen applauds. In the background: the CORE80 engine. According to Powertrain International Editor‑in‑Chief Fabio Butturi, the decision was straightforward: “Core80 represents exactly the kind of technical courage and innovation we want to highlight. The award truly belongs to the entire Core engine family, which opens a new era for AGCO Power across tractors
SOLUM Brings Retail in Sync to EuroShop 2026 with Integrated Retail Innovations23.2.2026 09:00:00 EET | Press release
SOLUM (KOSPI: 248070) brings ‘Retail in Sync’ to EuroShop 2026, unveiling new retail display innovations and integrated solutions that connect technology, operations and data to create more agile and scalable retail environments. By connecting pricing, communication and store operations within a unified framework, SOLUM aims to help European retailers improve efficiency, create new value and advance sustainability initiatives. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20260222220569/en/ At EuroShop, SOLUM will present practical applications that combine connected display technologies with data and analytics in real store environments. (Image: SOLUM) At EuroShop, SOLUM will present practical applications that combine connected display technologies with data and analytics in real store environments. Vision AI will demonstrate personalized product recommendations linked to electronic shelf labels (ESL), while Bluetooth Low E
Telekom Srbija Group Announces Platinum Sponsorship of EXPO 2027 Belgrade20.2.2026 13:32:00 EET | Press release
Telekom Srbija Group today announced its Platinum Sponsorship of EXPO 2027 Belgrade, marking a major milestone in the company’s continued leadership in digital innovation and infrastructure across the region. As a Platinum Sponsor, Telekom Srbija will play a central role in delivering the digital backbone of EXPO 2027, powering connectivity and enabling the state-of-the-art technological infrastructure that will support one of the largest international events ever hosted in Serbia. EXPO 2027 represents a defining moment for Belgrade, Serbia, and the wider region. For Telekom Srbija, the partnership is both a strategic commitment and a landmark opportunity to demonstrate the full strength of its technological ecosystem on a global stage. Telekom Srbija will also host its own pavilion at EXPO 2027, creating an immersive space to showcase its technologies, innovation platforms and future-facing solutions. Vladimir Lučić, CEO of Telekom Srbija, stated: “EXPO 2027 is a milestone moment for
In our pressroom you can read all our latest releases, find our press contacts, images, documents and other relevant information about us.
Visit our pressroom