Nagasaki University Presented Results Of a Specified Clinical Trial On The Use of L. lactis strain Plasma For Patients With COVID-19
Nagasaki University presented the results of a specified clinical trial on patients with COVID-19 using Lactococcus. lactis strain Plasma*1 (L.lactis Plasma, a postbiotic), researched and developed by Kirin Holdings Company, Limited (Kirin Holdings). The results of this research was presented at the 63rd Annual Scientific Meeting of the Japanese Respiratory Society on Sunday, April 30. Nagasaki University and Kirin Holdings have jointly filed a patent application for the findings of this specified clinical trial.
This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20230510005547/en/
Specified Clinical Research Contents (Graphic: Business Wire)
1 Lactococcus lactis subsp. lactis JCM 5805 is owned by the RIKEN BioResource Research Center (https://web.brc.riken.jp/en/)
- C urrent status of COVID-19
Since December 2019, COVID-19 infections have repeatedly caused pandemics, infecting 676.57 million people worldwide and killing 6.88 million (as of March 10, 2023). With the emergence of Omicron variants, the number of cases in Japan has increased, and the COVID-19 has become a more familiar infectious disease. Although SARS-CoV-2 vaccines have introduced widely and patients with mild illnesses account for a large proportion of the affected population, only a limited number of drugs are available in patients with mild illnesses who are not at risk of developing severe illnesses, and treatment is mainly based on symptomatic therapy.*2 Therefore, there is eagerly awaited for an easily accessible, safe, and effective treatment for COVID-19 in the community.
- What is L. lactis strain Plasma?
L. lactis strain Plasma was discovered by Kirin in 2010 as a lactic acid bacteria that activates plasmacytoid dendritic cells (pDC), which are a leader of the immune system. Previous basic studies showed that L.lactis Plasma stimulated pDC to have a first-line defense to viral infectious diseases. Previous clinical studies have also shown that L.lactis Plasma stimulated pDC and suppress the onset of an illness from influenza virus, rotavirus, and dengue. These scientific evidence of its immune function brought L. lactis Plasma registered as the first*4 Food with Functional Claims in Japan on August 2020.
- Specified Clinical Research Contents
Based on the results of Kirin Holdings’ research on L. lactis Plasma, Nagasaki University, as a research institute with significant achievements in the field of infectious diseases, interested in L. lactis strain Plasma which may effect in relieving symptoms in patientis with COVID-19, and has decided to conduct a specified clinical trial from December 2021.
Since December 2021, Kirin Holdings has been engaged in a specific clinical research project led by Dr. Kazuko Yamamoto, a lecturer at the Department of Respiratory Medicine, Nagasaki University Hospital (currently a professor and chair at the Division of Infectious Diseases, Respiratory and Gastroenterological Medicine (First Department of Internal Medicine), University of the Ryukyus Graduate School of Medicine). This is a multicenter, double-blinded, randomized controlled trial conducted at Nagasaki University Hospital as a core facility. The efficacy and safety of 14 days oral intake of 4 hard capsules containing L. lactis Plasma (400 billion L. lactis Plasma in total) or 4 hard capsules without L. lactis Plasma (placebo) was to be evaluated*5 by having 50 patients with COVID-19 in each group.
2 Approach to Pharmacotherapy for COVID-19 Version 15.1- the Japanese Association for Infectious Diseases
3 Secrets of Immunity - Kirin's L. lactis strain Plasma Research https://health.kirin.co.jp/en/about/about.html
4 The first brand in Japan to be registered with the Consumer Affairs Agency as a food with a functional claims for immune function.
5 Yamamoto K, et al. BMJ Open 2022;12:e061172
- Specified Clinical Trial Results
1, Change in subjective symptom overall score (primary endpoint)
The results of an overall score analysis of seven subjective symptoms (Cough, Shortness of breath, fatigue, Headaches, Anosmia and Dysgeusia, Anorexia, and Chest pain) on a 4-point scale (0 points: not affected, 1 points: little effect, 2 points: affected, 3 points: severely affected) showed no difference between the two groups.
2, Anosmia and Dysgeusia (secondary endpoints) (Graph1)
The percentage of patients who scored 0 (not affected) for smell and taste dysfunction among subjective symptoms were high in the L. lactis strain Plasma group compared to placebo group after day 9.
3, Percent change in blood pDC (secondary endpoint) (Graph2)
While the placebo group showed a significant decrease in % pDC in the blood during COVID-19 clinical course, the L. lactis strain Plasma group maintained % pDC in the blood.
4, Percent change in SARS-CoV-2 viral load (secondary endpoint) (Graph3)
The L. lactis strain Plasma group showed a significant reduction of SARS-CoV-2 viral load at day 4 of treatment whereas placebo group showed reduction at day 8.
5, Safety and adverse events
No critical adverse events of safety were observed in this study.
Although this study did not show an effect on the primary endpoint, the subjective symptom total score, these results suggested that maintained pDC by the intake of L. lactis strain Plasma may have resulted in an early reduction of SARS-CoV-2 and early recovery of smell and taste dysfunction.
Nagasaki University and Kirin hope that L. lactis Plasma will become one of the new treatment or adjunctive care to patients with mild COVID-19.
About Kirin Holdings
Kirin Holdings Company, Limited is an international company that operates in the Food & Beverages domain (Food & Beverages businesses), Pharmaceuticals domain (Pharmaceuticals businesses), and Health Science domain (Health Science business), both in Japan and across the globe.
Kirin Holdings can trace its roots to Japan Brewery which was established in 1885. Japan Brewery became Kirin Brewery in 1907. Since then, the company expanded its business with fermentation and biotechnology as its core technologies, and entered the pharmaceutical business in the 1980s, all of which continue to be global growth centers. In 2007, Kirin Holdings was established as a pure holding company and is currently focusing on boosting its Health Science domain.
Under the Kirin Group Vision 2027 (KV 2027), a long-term management plan launched in 2019, the Kirin Group aims to become A global leader in CSV*, creating value across our world of Food & Beverages to Pharmaceuticals. Going forward, the Kirin Group will continue to leverage its strengths to create both social and economic value through its businesses, with the aim of achieving sustainable growth in corporate value.
* Creating Shared Value. Combined added value for consumers as well as for society at large.
To view this piece of content from cts.businesswire.com, please give your consent at the top of this page.
View source version on businesswire.com: https://www.businesswire.com/news/home/20230510005547/en/
Corporate Communication Department
Kirin Holdings Company, Limited
Nakano Central Park South, 4-10-2 Nakano, Nakano-ku, Tokyo
General Affairs Section, Nagasaki University Hospital (Public Relations and Evaluations)
1-7-1 Sakamoto, Nagasaki, Nagasaki
About Business Wire
For more than 50 years, Business Wire has been the global leader in press release distribution and regulatory disclosure.
Subscribe to releases from Business Wire
Subscribe to all the latest releases from Business Wire by registering your e-mail address below. You can unsubscribe at any time.
Latest releases from Business Wire
European 100 Study Reveals: Despite Year-over-Year Improvements, Tremendous Opportunity to Enhance Hiring with AI, Automation and Experience Remains1.6.2023 12:00:00 EEST | Press release
Phenom released the second annual European Edition of its State of Candidate Experience Report, revealing significant improvement in the use of AI over one year and shining a spotlight on enormous opportunities for companies to enhance job seekers’ experiences through intelligence and automation. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20230601005156/en/ ‘State of Candidate Experience: 2023 Benchmarks Report — European Edition’ reveals, despite year-over-year improvements, tremendous opportunity to enhance hiring with AI, automation and experience remains. The second annual report provides recommendations, including small steps for making big impacts. (Photo: Business Wire) Phenom audited the top 100 European companies of the Global 500 list in three key areas of the talent journey: attraction, engagement and conversion, as well as the use of AI. By viewing their strengths, weaknesses and opportunities for improvement,
In Industry First, PUMA Creates Sustainability Report Podcast Series to Reach Out to Gen-Z1.6.2023 11:00:00 EEST | Press release
Sports company PUMA has created a podcast series to make its 2022 Sustainability Report more accessible and to reach a wider and younger audience. The RE:GEN REPORTS podcast features next-generation thinkers from six countries and distills the content of the report into 10 podcast episodes, of which the first three are available on all major podcast platforms on June 1. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20230601005537/en/ Sports company PUMA has created a podcast series to make its 2022 Sustainability Report more accessible and to reach a wider and younger audience. (Photo: Business Wire) The RE:GEN REPORTS podcast, as well as the recently announced Voices of a Re:Generation project, comes as a direct result of the feedback PUMA received at last year’s Conference of the People, which the company organized to discuss solutions for some of the fashion industry’s most pressing sustainability challenges with Gen-Z rep
invoX Pharma Increases Investment in pHion Therapeutics to Further Develop Next Generation of mRNA Vaccines1.6.2023 11:00:00 EEST | Press release
invoX Pharma Limited (“invoX”), a U.K.-based wholly-owned subsidiary of Sino Biopharmaceutical Limited (“Sino Biopharm”) (HKEX 1177 HK) with an advancing pipeline of innovative products, today announced that it has completed a second tranche of investment in pHion Therapeutics (“pHion”), a next-generation mRNA vaccine company. The transaction supports invoX’s strategy to be a fully integrated biopharmaceutical company and its ongoing commitment to deliver innovative life-saving therapies pHion is developing a pipeline of therapeutic and prophylactic vaccines focussed on oncology and infectious diseases. The company’s proprietary RALA platform can deliver anionic molecules such as mRNA and saRNA in a stealth-like way, evading detection, to generate a potent antigen-specific CD8+ T-cell response. The RALA peptide-based drug delivery system is based on a sequence of 30 amino acids which condenses anionic cargo, irrespective of size, into nanoparticles that are highly efficient at cellular
AVEVA Recognized as a Leader in the IDC MarketScape: Worldwide Process Manufacturing Execution System 2023 Vendor Assessment1.6.2023 10:00:00 EEST | Press release
AVEVA, a global leader in industrial software, driving digital transformation and sustainability, announced that it has been positioned in the Leaders Category in the IDC MarketScape: Worldwide Process Manufacturing Execution System 2023 Vendor Assessment (doc # EUR150526323, April 2023). This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20230601005060/en/ Keith Chambers, Vice-President, Operations Management Software, AVEVA. (Photo: Business Wire) According to the IDC MarketScape, “AVEVA MES is a model-driven solution that supports the modelling of operational workflows, production processes, and equipment. This configurable business process management approach enables standardization of operational processes across multisite operations and provides a centralized management platform for data analysis with visualization.” In explaining the strengths of AVEVA MES, the report said, “The model-driven and process-based approach have
Convincing Across the Board: LR Health & Beauty Receives Yet Another Award for Innovative Beauty Product1.6.2023 09:30:00 EEST | Press release
It’s been about four months since the top seller product “LR Zeitgard Pro Cosmetic Device” has been recognized for its outstanding design. Now, another award in the “Bath and Wellness” category has brought a cheerful mood to health & beauty product providers: Zeitgard Pro may now be presented with an additional “special mention” of the German Innovation Award 2023 – proving its ability to stand out among others as a cosmetic device for home use with exceptional user-centred design and surplus value. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20230531005576/en/ LR Health & Beauty receives the German Innovation Award for the Zeitgard Pro. (Graphic: Business Wire) “This renewed recognition proves that, with Zeitgard Pro, we managed to partially revolutionise the beauty industry”, Dr Andreas Laabs, CEO of LR Health & Beauty, pointed out. “I’m delighted that the renowned jury has acknowledged our ‘All-rounders’ user-friendlines
In our pressroom you can read all our latest releases, find our press contacts, images, documents and other relevant information about us.Visit our pressroom