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Novel Blood Pressure Stabilization Therapy Presented at Neuroscience 2021

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ONWARD Medical N.V. (Euronext: ONWD), a medical technology company creating innovative therapies to restore movement, independence, and health in people with spinal cord injury, today announced Grégoire Courtine, Ph.D., Professor of Neuroscience at the Swiss Federal Institute of Technology (EPFL) and co-Director of NeuroRestore, demonstrated the effectiveness of ONWARD’s ARC Therapy to stabilize blood pressure after spinal cord injury during his Presidential Special Lecture at NEUROSCIENCE 2021.

“Paralysis and loss of sensation are the more commonly known impacts of spinal cord injury, but a potentially more serious complication is orthostatic hypotension - low blood pressure tied to changes in body position,” said Professor Courtine. “We were excited to demonstrate and discuss how this new approach may provide a viable and important therapy for people with spinal cord injury.”

This novel therapy is currently being investigated in the STIMO HEMO study, building on a discovery first published in Nature that identifies the low thoracic spinal cord as a hemodynamic “hotspot”, which when stimulated via a proprietary algorithm called ARC Therapy, has the potential to restore blood pressure stability after spinal cord injury. ONWARD is developing and commercializing this therapy, leveraging its investigational ARCIM implantable device platform.

During his Presidential Special Lecture, Professor Courtine showed how stimulation of the hemodynamic hotspot elevated blood pressure in one of the STIMO HEMO participants. A video of that portion of the lecture can be viewed here.

More information about ONWARD’s investigational ARC Therapy can be found in this video.

About ONWARD

ONWARD Medical, N.V. (@onwdempowered) is a medical technology company creating innovative therapies to restore movement, independence, and health in people with spinal cord injury. ONWARD’s work builds on more than a decade of basic science and preclinical research conducted at the world’s leading neuroscience laboratories. ONWARD’s ARC Therapy, which can be delivered by implantable (ARCIM) or external (ARCEX) systems, is designed to deliver targeted, programmed stimulation of the spinal cord to restore movement and other functions in people with spinal cord injury, ultimately improving their quality of life. ONWARD has received three Breakthrough Device Designations from the FDA encompassing both ARCIM and ARCEX. The company’s first FDA pivotal trial for the ARCEX device, called Up-LIFT, commenced in January 2021 with plans to enroll 65 subjects at up to 15 centers worldwide.

ONWARD is headquartered at the High Tech Campus in Eindhoven, the Netherlands and the EPFL Innovation Park in Lausanne, Switzerland, with a growing U.S. presence in Boston, Massachusetts, USA. For additional information about the company, please visit ONWD.com and follow us on Twitter and LinkedIn.

Disclaimer

Certain statements, beliefs and opinions in this press release are forward-looking, which reflect the Company or, as appropriate, the Company directors’ current expectations and projections about future events. By their nature, forward-looking statements involve a number of risks, uncertainties and assumptions that could cause actual results or events to differ materially from those expressed or implied by the forward-looking statements. These risks, uncertainties and assumptions could adversely affect the outcome and financial effects of the plans and events described herein. A multitude of factors including, but not limited to, changes in demand, competition and technology, can cause actual events, performance or results to differ significantly from any anticipated development. Forward looking statements contained in this press release regarding past trends or activities should not be taken as a representation that such trends or activities will continue in the future. As a result, the Company expressly disclaims any obligation or undertaking to release any update or revisions to any forward-looking statements in this press release as a result of any change in expectations or any change in events, conditions, assumptions or circumstances on which these forward-looking statements are based. Neither the Company nor its advisers or representatives nor any of its subsidiary undertakings or any such person’s officers or employees guarantees that the assumptions underlying such forward-looking statements are free from errors nor does either accept any responsibility for the future accuracy of the forward-looking statements contained in this press release or the actual occurrence of the forecasted developments. You should not place undue reliance on forward-looking statements, which speak only as of the date of this press release.

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Contact information

For general inquiries:
info@onwd.com

For media inquiries:
Bryan Gibbs, Finn Partners
bryan.gibbs@finnpartners.com
+19737134709

For European Media and Investor Enquiries:
Gunther De Backer, Backstage Communication
gunther@backstagecom.be
Tel: +32 (0)475 903 909

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