numares’ Novel Multi-marker Kidney Function Testing Shows Promising Results in US Validation Study
numares today announced that its novel multi-marker approach for the accurate assessment of glomerular filtration rate (GFR) shows promising results in a US based clinical validation study. Using serum, GFRNMR evaluates a metabolite constellation of three metabolites combined with Cystatin C, age and sex. Compared to existing serum-based GFR methods, this multi-marker algorithm more accurately reflects gold-standard invasive clearance testing methods. GFRNMR will create an accessible, affordable, and reliable new diagnostic standard for patients.
The validation was performed in a retrospective study using US-based and European clinical data. The new test is based on numares’ metabolomics approach: a combination of serum biomarkers, forming a metabolite constellation, analyzed by advanced nuclear magnetic resonance (NMR) spectroscopy and evaluated by numares’ proprietary AI-driven diagnostic software. After training the test on US-based clinical data, 461 samples of international origin were used to validate the metabolite constellation.
“The outcome of this validation study surpasses the performance of the existing equations that are used to estimate kidney function,” says Dr. Volker Pfahlert, Chief Executive Officer of numares. “Our vision was to obtain a glomerular filtration rate (GFR) value from a simple blood sample that is comparable to the much more involved and invasive plasma clearance method. We are closer to the vision, as never before, to help identify and quantify reduced kidney function in patients with a more accurate, easy-to-access, and affordable diagnostic standard.”
Fifteen percent of U.S. adults (37 million people) are estimated to have chronic kidney disease*. Determining kidney function is important in many different medical conditions, e.g., patients with kidney transplants, late complications in diabetes management, patients with chronic congestive heart failure, or in dosing of nephrotoxic drugs.
The GFRNMR test will soon be further validated in additional clinical studies with ~1,500 patient samples comprised of additional clinical conditions and broader demographics. Based on these results, numares plans to submit the GFRNMR test for FDA Clearance in the first half 2021.
numares AG, based in Regensburg, Germany, is a fast-growing innovative diagnostics company that applies machine learning to metabolomics data to develop advanced analytical tests for high-throughput use in clinical diagnostics. The AXINON® System employs nuclear magnetic resonance (NMR) spectroscopy to create a “numaric” spectrum to evaluate metabolic constellations. Magnetic Group Signaling (MGS® ) is a proprietary technology that enables NMR for highly standardized and rapid throughput testing. Metabolic tests stand as an important pillar in precision medicine to address unmet needs in cardiovascular, kidney, liver, and neurological diseases. You will find more information at https://www.numares.com/
For further information
Tel.: +49 941 280 949-14
About Business Wire
For more than 50 years, Business Wire has been the global leader in press release distribution and regulatory disclosure.
Subscribe to releases from Business Wire
Subscribe to all the latest releases from Business Wire by registering your e-mail address below. You can unsubscribe at any time.
Latest releases from Business Wire
ONWARD Announces Publication in Nature Demonstrating Blood Pressure Stabilization in People with Spinal Cord Injury27.1.2021 19:00:00 EET | Press release
ONWARD today announced the publication of a study in the journal, Nature, which found targeted electrical spinal cord stimulation stabilizes blood pressure in people with spinal cord injury (SCI). “A serious and underrecognized result of spinal cord injury is unstable blood pressure, which can have devastating consequences that reduce quality of life and are life threatening. Unfortunately, there are no effective therapies for unstable blood pressure after spinal cord injury,” said Dr. Aaron Phillips, PhD, a member of the Hotchkiss Brain Institute and Libin Cardiovascular Institute at the Cumming School of Medicine (CSM) and co-lead author of the study. “We created the first platform to understand the mechanisms underlying blood pressure instability after spinal cord injury, which allowed us to develop a new cutting-edge solution.” Loss of movement and sensation are the most commonly known impacts of spinal cord injury, but SCI is also frequently accompanied by other effects that chall
Esri Launches ArcGIS Platform27.1.2021 19:00:00 EET | Press release
Esri, the global leader in location intelligence, today announced the launch of ArcGIS Platform, a geospatial platform as a service (PaaS) for developers that need to integrate location capabilities into their apps, business systems, and products. ArcGIS Platform gives developers direct access to Esri's powerful location services using the APIs and web frameworks of their choice. "ArcGIS Platform lets users build their own products or integrate Esri services into existing software," said Jack Dangermond, Esri founder and president. "This PaaS makes it easier for software developers to access geospatial technology." "With the release of ArcGIS Platform, developers now have access to professional-grade content and capabilities they can readily plug into their apps, allowing them to stay on budget while delivering enormous value by reducing time to market," said David Cardella, Esri product manager for developer technologies. Scaling with developers and their apps, ArcGIS Platform lets cu
Xsolla Establishes New Games Industry Collective, Xsolla Diamond Club27.1.2021 18:32:00 EET | Press release
Xsolla, the game commerce company powered by Transaction Engine and Business Engine to help developers and publishers market, sell, connect and optimize their games globally, is now accepting new members to the Xsolla Diamond Club, a professional community of like-minded video game developers and publishers looking to build successful businesses who can connect, learn proven methods and solve shared challenges. Membership to the collective is open to Xsolla clients and potential new partners. Diamond Club members can collaboratively tackle problems around funding, launching, distribution and monetization. To welcome new members, Xsolla is providing free tickets to upcoming sponsored virtual trade shows in 2021. Prospective members can apply to select the event that they would like to attend. After attending their first show, members will also have the benefit of purchasing discounted tickets to 40+ other future events in 2021, including: Taipei Game Show – January 28-31 Pocket Gamer –
C3 AI Reinvents No Code AI with the Introduction of C3 AI Ex Machina27.1.2021 17:00:00 EET | Press release
C3 AI (NYSE: AI), the world’s leading provider of enterprise AI software, today announced the general availability of C3 AI® Ex Machina, a next-generation predictive analytics application that empowers anyone to develop, scale, and produce AI-based insights without writing code. Analysts, operators, and subject matter experts across all industries and business functions are increasingly required to develop predictive and prescriptive insights compiled from vast and disparate datasets. While there are many no-code tools available that lower the barrier for users to build ML models and perform data analysis, none provide end-to-end capabilities that enable them to capture and process the volume and variety of data required, automatically generate interpretable AI models, and productize, deploy, and scale the results across their company. Current predictive analytics tools are typically complicated to use and limit the ability of their insights to drive real business outcomes. C3 AI Ex Ma
Philip Morris International Named to the 2021 Bloomberg Gender-Equality Index, Recognizing Company’s Commitment to Advancing Gender Equity27.1.2021 16:18:00 EET | Press release
Philip Morris International Inc. (PMI) (NYSE: PM) has today been added to the 2021 Bloomberg Gender-Equality Index (GEI) for its transparency in gender reporting and advancing women’s equity. This recognition underscores PMI’s work to progress gender equity in the workplace and to ensure equal opportunities for all employees. “I am delighted that PMI has been named to the 2021 Bloomberg Gender-Equality Index for our focus on advancing gender equity,” said Silke Muenster, Chief Diversity Officer at PMI. “We count on inclusion to better our organization and believe everyone has an important role to play in making PMI a more inclusive and diverse employer. From striving to improve our gender balance at all levels to maintaining our global leadership on equal pay, our efforts are not only an essential part of being a responsible corporate citizen and contributing to our shared global sustainability goals but also crucial to our progress toward delivering a smoke-free future.” The Bloomberg
Coty Announces Consolidation of Fragrance Manufacturing Operations with Intended Closure of Site in Cologne, Germany27.1.2021 16:10:00 EET | Press release
Coty Inc. (NYSE: COTY), one of the world’s leading beauty companies today announced the planned closure of its manufacturing site in Cologne, Germany. The move comes as Coty consolidates global fragrance operations. The Cologne site currently employs approximately 300 people and produces a range of fragrance products. The closure, which will occur in stages, will be preceded by the completion of all appropriate legal processes and is expected to be completed by Summer 2022. Richard Jones, Chief Global Supply Chain and R&D Officer at Coty, said: “We have taken this difficult decision to consolidate our fragrance manufacturing capacity in order to increase the efficiency of our operations. Coty is the world’s leader in fragrance, but our network has been operating over-capacity in recent years and the considerable impact of COVID-19 has accelerated the need to take action. This move will address the imbalance to increase our competitiveness and ensure we fully leverage our scale and rema
UnitedLex Integrates Microsoft Cloud to Globally Scale Digital Transformation of Legal Services27.1.2021 16:00:00 EET | Press release
UnitedLex, a leading technology and legal services company, has integrated Microsoft Cloud services to globally scale UnitedLex Vantage, a holistic, turnkey technology platform built to revolutionize the customer experience and transform the legal function into a first-class digital citizen. UnitedLex has integrated Microsoft solutions into its software portfolio since 2008 and has deep experience working closely with Microsoft. UnitedLex Vantage delivers a flexible, secure, and scalable platform, powering all enterprise legal workflows. Vantage comes with a vastly reduced implementation time (a matter of days versus months), a 20 percent increase in work efficiency, significant cost savings across overall legal and IT spend, and most crucially: new revenue opportunities for the business. UnitedLex Chief Technology Officer Sean Jennings said, “We are pleased to deepen our longstanding relationship with Microsoft. The Vantage platform represents a substantial investment for UnitedLex to
In our pressroom you can read all our latest releases, find our press contacts, images, documents and other relevant information about us.Visit our pressroom