PerkinElmer Launches Industry First No-Wash Immunoassay For Phospho Ubiquitin Ser65 to Help Drive Neuroscience Disease and Therapeutics Research Forward
PerkinElmer, Inc., a global leader committed to innovating for a healthier world, today launched the life science industry’s first no wash Ubiquitin phosphorylation at Serine 65 immunoassay for studying defective mitophagy biological mechanisms that have been broadly associated with diseases such as Parkinson’s and Alzheimer’s. The new PerkinElmer Cisbio HTRF® Phospho-Ubiquitin (Ser65) Cellular Kit takes analysis efficiency and accuracy to the next level compared to existing techniques such as Western blot and is aimed at helping scientists discover new therapeutic candidates earlier in the disease cycle.
The innovative assay leverages TR-FRET technology to bring high sensitivity across a wide range of analytes and greater study specificity to the Phospho-Ubiquitin (Ser65) intersection point that has been shown to play a key role in mitophagy dysfunction and breakdowns in the complex network between neurons and glial cells which can lead to neurodegenerative disease.
Efficient and streamlined workflows and accelerated data delivery are also provided by the immunoassay’s mix and read method approach and compatibility with microplate readers such as PerkinElmer’s VictorTM Nivo® or EnVision® systems. Analysis can also be automated and run in high throughput formats.
“With over 70 Million people around the world living with Alzheimer’s and Parkinson’s and the sheer complexity of how neurodegenerative disease develops in the brain, it is critical that scientists have the tools they need to help unlock promising avenues of study such as modulating mitophagy impairment,” said Alan Fletcher, VP and GM of Life Sciences, PerkinElmer. “With this new immunoassay, researchers now have a more efficient and effective way to study a key biomarker which could lead to exciting new therapeutic candidates.”
The new PerkinElmer Cisbio HTRF Phospho-Ubiquitin (Ser65) Cellular Kit, joins PerkinElmer’s range of immunoassay kits and reagents for neuroscience applications across HTRF, Alpha, LANCE® and DELFIA®. For more information please visit: https://learn.cisbio.com/lp/guide-neurodegenerative-diseases-and-neuroinflammation-pathways; https://uk.cisbio.eu/dd/by-universe/neuroscience
PerkinElmer enables scientists, researchers and clinicians to address their most critical challenges across science and healthcare. With a mission focused on innovating for a healthier world, we deliver unique solutions to serve the diagnostics, life sciences, food and applied markets. We strategically partner with customers to enable earlier and more accurate insights supported by deep market knowledge and technical expertise. Our dedicated team of about 13,000 employees worldwide is passionate about helping customers work to create healthier families, improve the quality of life, and sustain the wellbeing and longevity of people globally. The Company reported revenue of approximately $2.9 billion in 2019, serves customers in 190 countries, and is a component of the S&P 500 index. Additional information is available through 1-877-PKI-NYSE, or at www.perkinelmer.com.
+1 508 380 2902
About Business Wire
For more than 50 years, Business Wire has been the global leader in press release distribution and regulatory disclosure.
Subscribe to releases from Business Wire
Subscribe to all the latest releases from Business Wire by registering your e-mail address below. You can unsubscribe at any time.
Latest releases from Business Wire
Abionic Launches First Covid-19 Severity Test to Triage Patients Quickly and Accurately26.11.2020 07:00:00 EET | Press release
Abionic SA, a Swiss Medtech firm based in Lausanne, has developed the cSOFA score, a tool to assess the severity of Covid-19. The cSOFA score (Covid Sequential Organ Failure Assessment) measures the likelihood of clinical deterioration in Covid-19 patients, enabling triage and assignment to the general ward or intensive care units (ICU) upon admission and during the patients’ hospital stay. A low score allows medical decisions to be made on safely discharging patients from the hospital or moving them from the ICU to the general ward, freeing up much-needed ICU and hospital capacities. In the wake of the Covid-19 pandemic, countries around the globe are faced with increasing occupancy rates in hospitals, particularly in ICUs, and many ICUs at or near capacity. Patient triage, until now, has relied mostly on patient age, a criterion sometimes criticized for being discriminatory. The cSOFA score enables a shift from demographic to medical criteria, taking into account the severity of each
Mavenir and Airtel Demonstrate O-RAN RIC (RAN Intelligent Controller) at Global O-RAN ALLIANCE Plugfest hosted by Airtel in India26.11.2020 06:00:00 EET | Press release
Bharti Airtel (“Airtel”), India’s largest integrated telco, together with Mavenir, demonstrated O-RAN Intelligent Controller (RIC), at the recent Global O-RAN ALLIANCE Plugfest it hosted. The Global Plugfest, which was a first for the India region participation, showcased the growing maturity of the O-RAN ecosystem. The event allowed participants to integrate and validate conformance & interoperability of the solutions implemented based on O-RAN defined architecture & specifications to accelerate readiness of solutions for commercial deployments. The O-RAN Intelligent Controller (RIC) demonstrated by Mavenir and Airtel makes use of advanced machine learning algorithms to optimize network performance. This demonstration showed RIC in action, ingesting configuration data and performance metrics from a demonstration RAN, and iteratively optimizing the configuration parameters to achieve improvement in key performance indicators. The target objective function is configurable by the operato
MEDIROM Healthcare Technologies Inc. Announces Filing of Registration Statement for Proposed Initial Public Offering on NASDAQ25.11.2020 18:00:00 EET | Press release
MEDIROM Healthcare Technologies Inc. (“MEDIROM”), the healthcare company which runs branded relaxation salons in Japan, today announced it has publicly filed a registration statement on Form F-1 with the U.S. Securities and Exchange Commission (“SEC”) relating to a proposed initial public offering of its American Depositary Receipts which represent the common shares of the Company. The number of ADRs to be offered and the price range for the proposed offering have not yet been determined. MEDIROM has applied to list its ADR on Nasdaq Capital Market. Maxim Group LLC is acting as lead manager and representative of the underwriters for the offering. The proposed offering will be made only by means of a prospectus. Once available, a copy of the preliminary prospectus related to the offering may be obtained at the SEC's website at http://www.sec.gov or from the offices of Maxim Group LLC, Attention: Prospectus Department, 405 Lexington Ave Second Floor, New York, NY 10174, telephone: 1-212-
Xinhuanet: Chengdu’s Talent Appeal Spurs the City’s Embrace of the World25.11.2020 17:39:00 EET | Press release
“Chengdu is increasingly attracting skilled talent and entrepreneurs to integrate, put down roots, and start businesses in the city. The city continues to become more appealing, which in turn further promotes its international development,” said Xu Wen, head of Southwestern business at PwC’s Chengdu branch. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20201125005704/en/ Xu Wen, head of Southwestern business at PwC’s Chengdu branch, takes a media interview (Photo: Business Wire) In the “City of Opportunity 2020” report released by PwC this year, Chengdu ranked 5th in China, only surpassed by Beijing, Shanghai, Guangzhou, and Shenzhen. Xu sees Chengdu’s great advantage as a “new first-tier” city reflected in the city’s appeal to skilled talent. “With China’s economy undergoing transformation and upgrading, innovation capabilities are becoming more and more important. In this context, cultivating developmental advantages is a c
ViacomCBS to Sell Simon & Schuster to Penguin Random House for $2.175 Billion25.11.2020 17:00:00 EET | Press release
ViacomCBS Inc. (NASDAQ: VIAC, VIACA) today announced it has entered into a definitive agreement to sell the publishing business Simon & Schuster (“Simon & Schuster”) to Penguin Random House LLC (“Penguin Random House”), a wholly owned subsidiary of Bertelsmann SE & Co. KGaA, for $2.175 billion in cash. This divesture follows a strategic review of non-core assets ViacomCBS undertook early in 2020. Proceeds from the transaction will be used to invest in ViacomCBS’s strategic growth priorities, including in streaming, as well as to fund the dividend and pay down debt. This transaction is the outcome of a highly competitive auction that attracted interest from buyers around the world, reflecting Simon & Schuster’s position as one of the world’s best known publishing brands. Simon & Schuster has more than 30 publishing units across adult, children, audio and international. Its portfolio of best-selling authors includes Stephen King, Doris Kearns Goodwin and Jason Reynolds, and it owns a ric
Enhancing the HD-PLC™ Security Functions25.11.2020 17:00:00 EET | Press release
HD-PLC Alliance *1 has started standardization work that will allow the use of enhanced network security functions, with the aim of using High-Definition Power Line Communication technology in the fields of smart grids and distributed power management. HD-PLC™*2 (hereinafter referred to as HD-PLC) technology has already been standardized as IEEE 1901 (Broadband over Power Line Networks for MAC and PHY) by the IEEE Standards Association*3 . This technology is particularly attracting attention in Europe as a communication infrastructure that can be used for distributed power management of energy. Therefore, the current security functions will be enhanced and expanded, including making the technology compatible with strong authentication functions required for use in large-scale networks. Current HD-PLC technology offers extremely high security at the device level, including continuous encrypted communication and authentication between compatible devices. However, for PLC equipment to be
In our pressroom you can read all our latest releases, find our press contacts, images, documents and other relevant information about us.Visit our pressroom