Business Wire

Stallergenes Greer Initiates a European Paediatric Phase III Study With Staloral® Birch


Stallergenes Greer, a biopharmaceutical company specialising in the diagnosis and treatment of respiratory allergies, announced today the initiation of a Phase III clinical study (YOBI, YOung patients and BIrch allergy) to confirm the safety and efficacy of Staloral® Birch in children and adolescents with birch pollen-induced allergic rhino-conjunctivitis with or without asthma. The randomised, double-blind placebo-controlled Phase III study will involve approximately 80 sites in 12 European countries.

Allergic rhino-conjunctivitis is a worldwide disease and a global health burden affecting more than 500 million people, who are at higher risk of developing rhinitis exacerbation and asthma than the general population1..Birch is among the strongest allergy-producing trees in northern Europe. The allergic potential of other trees belonging to the birch homologous group, such as alder and hazel, is also increasing steadily2.

In children and adolescents, allergic rhino-conjunctivitis can lead to sleep problems, fatigue, missed school days and can complicate outdoor activities3. Individuals sensitised at a young age are also more at risk of developing asthma. The younger the children are, the higher their risk of developing asthma, which highlights the relevance of early causal treatment in paediatric patients to slow the worsening of allergy symptoms4. Allergen immunotherapy (AIT) is currently the only available therapeutic treatment that has the potential to uniquely alter the natural course of the disease5. In its liquid form, sublingual AIT can provide a needle-free and flexible treatment for children and adolescents.

Allergic rhino-conjunctivitis induced by birch and related trees can lead to a spiraling of respiratory symptoms and conditions in the paediatric population. The YOBI study will contribute to addressing a global health burden, while deepening our knowledge of AIT with the aim of improving patient outcomes for children and adolescents with birch-induced allergies,” said Professor Oliver Pfaar, International Coordinator of the YOBI study, Head of Rhinology and Allergy, Department of Otorhinolaryngology, Philipps-Universität Marburg, Germany.

Stallergenes Greer’s AIT treatments have proven their efficacy and safety in both clinical trials and the real world, stated Michele Antonelli, CEO of Stallergenes Greer. “ This paediatric Phase III study, illustrates our determination to further develop evidence-based solutions and build on robust datasets and cutting-edge research technologies to advance precision medicine combined with dose adaptation for the benefit of patients with allergies, the medical community, and health systems.


Staloral® is a sublingual solution of allergen extracts for AIT. It is indicated in the treatment of seasonal or perennial allergic rhinitis, rhino-conjunctivitis and mild to moderate allergic asthma in adults and, in certain territories, in the paediatric population (children over 5 years of age).

Clinical evidence of the efficacy of Staloral® is globally consistent over the clinical studies Stallergenes Greer conducted versus placebo. The effectiveness of Staloral® as a causal treatment for allergic rhino-conjunctivitis beyond clinical trials was also assessed by Stallergenes Greer’s real-world studies EfficAPSI and BREATH (Bringing Real-World Evidence to Allergy Treatment for Health).


Allergic rhinitis/allergic rhino-conjunctivitis (AR/ARC) is a chronic disorder of the upper airways that is caused by allergen exposure and the resulting IgE-mediated inflammation of the nose and, to a less extent, the eyes. Allergic rhinitis can notably include symptoms such as sneezing, a runny nose, wheezing, cough, itching, and watery/itchy eyes. Symptoms may be severe and significantly impact the patient’s quality of life, as well as worsen over time with progression towards asthma4.

First intention symptomatic treatments such as antihistamines and nasal corticosteroids provide temporary relief to patients. The primary therapeutic goals of AIT include reducing symptoms, reducing symptomatic medication use, and improving allergy-related quality of life. AIT achieves these goals and can alter the course of the disease, with benefits persisting in many patients for several years after treatment discontinuation6.


Headquartered in Baar (Switzerland), Stallergenes Greer International AG is a global healthcare company specialising in the diagnosis and treatment of allergies through the research, development and commercialisation of allergen immunotherapy products and services. Stallergenes Greer International AG is the parent company of Greer Laboratories, Inc. (whose registered office is in the United States) and Stallergenes SAS (whose registered office is in France). For more information, visit

1. Bousquet, J., et al., Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy, 2008. 63 Suppl 86: p. 8-160.
2. Biedermann, T., et al., Birch pollen allergy in Europe. Allergy, 2019. 74(7): p. 1237-1248.
3. Canonica GW, Bousquet J, Mullol J, Scadding GK, Virchow JC. A survey of the burden of allergic rhinitis in Europe. Allergy. 2007;62 Suppl 85:17-25. doi:10.1111/j.1398-9995.2007.01549.x
4. Klimek, L., et al., ARIA guideline 2019: treatment of allergic rhinitis in the German health system. Allergo journal international, 2019. 28(7): p. 255-276.
5. Roberts G, Pfaar O, Akdis CA, et al. EAACI Guidelines on Allergen Immunotherapy: Allergic rhinoconjunctivitis. Allergy. 2018;73(4):765-798. doi:10.1111/all.13317
6. Hesse, L., et al., Allergen immunotherapy for allergic airway diseases: Use lessons from the past to design a brighter future. Pharmacology & Therapeutics, 2022: p. 108115.

To view this piece of content from, please give your consent at the top of this page.

Contact information

Stallergenes Greer
Catherine Kress
Tel: +33 (0)1 55 50 26 05

About Business Wire

For more than 50 years, Business Wire has been the global leader in press release distribution and regulatory disclosure.

Subscribe to releases from Business Wire

Subscribe to all the latest releases from Business Wire by registering your e-mail address below. You can unsubscribe at any time.

Latest releases from Business Wire

Lenovo ranks Eighth in the Gartner® Supply Chain Top 25 for 202330.5.2023 20:11:00 EEST | Press release

Lenovo has once again been named in the Gartner Supply Chain Top 25 for 2023, ranking eighth in this list of global companies with supply chains. The Gartner Supply Chain Top 25 identifies, celebrates and profiles supply chain excellence on a global scale, and by target region and industry. Now in its 19th year, the global ranking is a peer benchmark for chief supply chain officers (CSCO) and their teams, inspiring innovation and leadership. The Supply Chain Top 25 ranking comprises two main components: business performance and opinion. Business performance in the form of public financial and ESG (environmental, social, governance) data provides a view into how companies have performed in the past three years, while the opinion component offers an eye to future potential and reflects leadership in the supply chain community. These two components are combined into a total composite score. Lenovo has fully embraced digital transformation within its complex and global supply chain, and by

Wemade’s MMORPG MIR M Reveals New Content ‘Monster Dungeon’30.5.2023 16:00:00 EEST | Press release

Wemade's MMORPG MIR M: Vanguard and Vagabond showcased new content, "Monster Dungeon," on May 30th. This press release features multimedia. View the full release here: MIR M reveals new “Monster Invasion” content on May 30. (Graphic: Wemade) Users can obtain the "Demonic Stones" of field monsters they have defeated. Each "Demonic Stone" can be used to summon that monster in Monster Dungeon. By defeating all summoned monsters, users can obtain "Essence" items as rewards. "Essence" items can be registered to the Monster Codex to increase character stats. MIR M will be holding the event "Grand Operation Defeat Giant Scarecrow" until the update on June 13th. Users can defeat the Giant Scarecrow that appears in the Ginkgo Valley area to obtain gifts such as "Giant Scarecrow Raid Chests" and "Giant Scarecrow Demonic Stones." By using "Giant Scarecrow Demonic Stones," users can obtain Demonic Stones that can be used to summon boss mons

Q4 Inc. Set to Transform IR Effectiveness with Generative AI on the Q4 Platform30.5.2023 14:30:00 EEST | Press release

Q4 Inc. (TSX: QFOR) (“Q4” or “the Company”), the leading capital markets access platform, is excited to announce progress on pioneering generative artificial intelligence (“AI”) that is purpose built for Investor Relations (“IR”) effectiveness to help automate common tasks and accelerate decision making. By combining AI with the industry’s only end-to-end IR platform, IROs will be able to find insights exclusive to them built on a pool of their own proprietary program data and capital markets data aggregated on the Q4 Platform. “We are embarking on one of the most exciting product cycles in our history,” remarked Darrell Heaps, Founder and CEO of Q4. “Our offerings will unlock tremendous new opportunities for our clients to benefit from the unmatched richness and scale of our proprietary data with the integration of generative AI. The result for clients will simply be effective investor relations and better insights for our investment banking and equity capital markets clients.” In the

Kinaxis RapidResponse Available on Google Cloud Marketplace30.5.2023 14:00:00 EEST | Press release

Kinaxis ® Inc. (TSX: KXS), the authority in driving agility for fast, confident decision-making in an unpredictable world, announced today announced that the market’s leading supply chain management solution, Kinaxis RapidResponse® is available on Google Cloud and in the Marketplace. RapidResponse supports key business processes such as demand and supply planning, integrated business planning, sales and operations planning (S&OP) and inventory management, and delivers end-to-end transparency with its control tower capabilities. Concurrent planning breaks down organizational silos, unifies disparate data under a single all-inclusive data model, and codifies business-wide trust through the continuous alignment of everyone and everything across a company’s end-to-end supply chain. “We’re pleased the Kinaxis platform is now available on Google Cloud,” said Dai Vu, Managing Director, Cloud Marketplace & ISV GTM Initiatives at Google Cloud. “Customers can deploy Kinaxis via the Google Cloud

New Clinical Data on Vuse Illustrates Beneficial Public Health Impact of Tobacco Harm Reduction30.5.2023 13:00:00 EEST | Press release

New results from one of the largest ever vapour product studies, which analysed BAT’s flagship vapour brand Vuse, have been published in the journal of Internal and Emergency Medicine ( This press release features multimedia. View the full release here: One of the largest ever vapour product studies compared clinical measurements from exclusive Vuse consumers with smokers (Graphic: Business Wire) The study compared clinical measurements from exclusive Vuse consumers with smokers. The results of the study show that participating Vuse consumers had favourable differences in biomarkers of exposure (BoE) and biomarkers of potential harm (BoPH) relevant to smoking-related diseases when compared to smokers. Vuse users have shown significantly lower biomarkers of exposure for priority cigarette smoke toxicants as defined by the World Health Organization (WHO)iii. The data al

In our pressroom you can read all our latest releases, find our press contacts, images, documents and other relevant information about us.

Visit our pressroom