Business Wire

Wellcome Sanger Institute Selects Arima Genomics as HiC Technology Partner; Company Announces Early Access Program for high-coverage HiC

Share

Arima Genomics, Inc., a biotechnology company accelerating the adoption of the genome structure information, announced today that its new high-coverage HiC technology has been evaluated and implemented at the Wellcome Sanger Institute for projects, including the Darwin Tree of Life project, in an effort to explore the true genetic diversity between species and between individuals within a species.

The Wellcome Sanger Institute is one of the world's leading genome science research hubs that advances the world’s understanding of the genetics of human health and disease. The Institute's research programs range from cancer genomics, single-cell human genetics, population human genetics and species evolution, and its findings have unlocked critical insights in the areas of drug development, new treatment options and novel biomaterials.

HiC data captures the three-dimensional folding patterns of genomes within cells, and consequently, it facilitates the assembly of its linear unfolded state. Such a linearized genome is the foundational representation of an organism’s DNA and is commonly used to compare genomes within and between species in order to elucidate the link between genetics and disease. The Wellcome Sanger Institute is using the next generation of Arima Genomics’ HiC kits developed to generate sequencing data with improved coverage uniformity. “The high-coverage HiC data provides more evenly distributed shotgun reads and associated long range linkages that aid the scaffolding of contigs to improve assembly contiguity,” said Michael Quail, Principal Scientific Manager, DNA Pipelines R&D at the Wellcome Sanger Institute. “The newer Arima kits are being used because we found them to be robust across a range of tissue types from diverse vertebrate and invertebrate species. Kit robustness to a diversity of samples is an essential requirement for the Darwin Tree of Life Project.”

Feedback and data generated by early customers helped to optimize toward low-input capability and varied sample storage conditions. “The high-coverage HiC kits generated high signal-to-noise libraries in samples with limited input amounts such as 2uL of zebra finch blood,” said Olivier Fedrigo, Director of the Vertebrate Genome Laboratory, The Rockefeller University. “Additionally, to mimic real world sample collection and storage conditions, we collected blood in ethanol tubes and preserved them at room temperature for a week – the Arima kits generated high-quality data despite potential sample degradation expected from such harsh conditions. Adaptability to field conditions is a key feature for the Vertebrate Genome Project (VGP), the Darwin Tree of Life Project, and the larger Earth BioGenome Project (EBP).”

In response to the community’s expectation that the production scale of genome assembly projects will get bigger, Arima is collaborating with academic partners to validate automation compatibility and optimize workflow speed to ensure quality, efficiency and convenience for the customer. “Nearly 20 years after the first draft assembly of the human genome was released, we are finally in a position to generate genome assemblies affordably at a cost less than $5,000 per gigabase genome size, nearly a million-fold down from $1 billion per gigabase two decades ago,” said Harris Lewin, Distinguished Professor at UC Davis and chair of the EBP. “Thanks to technological advances from industry partners, it is now possible to ascertain assemblies at very fine resolution in part because of the improved read coverage uniformity, and, also quickly in a span of days – creating an inflection point toward launching EBP with the aim to assemble DNA of all the planet’s eukaryote biodiversity, 1.5 million known species, over a period of 10 years.”

In addition to informing the linear unfolded states of genomes, HiC can also inform misfolded states of cancer genomes. In particular, cancer is a disease largely caused by genomic aberrations and such aberrations can be more accurately identified when the genome is observed from its innate three-dimensional structural state as captured by HiC. “Indeed, the folding information from HiC has proven to be an important component in our development of new algorithms for assembling structurally accurate cancer genomes,” said Shilpa Garg, K99 Fellow at Dana Farber Cancer Institute and Harvard Medical School. “More broadly, structurally accurate cancer genomes can help deconvolute the clonal architecture and evolution of tumor aberrations that impact therapeutics.”

As part of the plan to bring the latest Arima high-coverage kits to market, Arima Genomics today announced an Early Access Program. “Through this program, we aim to partner with the community to further validate the utility of genome structure information toward multiple areas of genomic science, from cancer evolution, T2T genome finishing, pan-genome analyses and species evolution, across a broad range of sample types and input amounts,” said Anthony Schmitt, Senior Vice President of Science at Arima Genomics. “We believe that the structural information of the genome is as fundamental as the sequence to shape the next generation of genomic discoveries – via launching relatable products, expanding structural applications, and financing our programs reliably from the proceeds of our Series A from earlier this year, we are excited to be part of this future.”

About Arima Genomics

Arima Genomics, Inc. is a biotechnology company that aims to accelerate the understanding of genome sequence and structure and their role in health, disease, and species evolution. For additional information, please visit: http://www.arimagenomics.com.

Contact information

Siddarth Selvaraj
CEO, Arima Genomics
sid@arimagenomics.com

About Business Wire

For more than 50 years, Business Wire has been the global leader in press release distribution and regulatory disclosure.

Subscribe to releases from Business Wire

Subscribe to all the latest releases from Business Wire by registering your e-mail address below. You can unsubscribe at any time.

Latest releases from Business Wire

Pacific Drilling Commences Voluntary Chapter 11 Proceedings; Restructuring Support Agreement to Eliminate All $1.1 Billion of Bond Debt; World-wide Operations Expected to Continue as Usual31.10.2020 02:52:00 EETPress release

Pacific Drilling S.A. (NYSE: PACD) announced today that it and certain of its domestic and international subsidiaries have filed voluntary petitions for relief under Chapter 11 of the United States Bankruptcy Code in the United States Bankruptcy Court for the Southern District of Texas and have entered into a restructuring support agreement with an ad hoc group of the largest holders of its outstanding bond debt. This consensual financial restructuring transaction will eliminate the Company’s approximately $1.1 billion in principal amount of outstanding bond debt through the cancellation and exchange of debt for new equity in the reorganized Company. The Company also announced today that it has repaid its $50 million first lien superpriority revolving credit agreement with Angelo, Gordon Energy Servicer, LLC, as administrative agent and the lenders party thereto. With approximately $120 million of cash and cash equivalents as of October 30, 2020, and seven of the most advanced high-spe

Homestead Capital Closes Fund III at Target, Surpasses $1 Billion in Cumulative AUM31.10.2020 02:07:00 EETPress release

Homestead Capital USA LLC (“Homestead”), a private equity firm investing in farmland in the United States, has held a final close of its third fund, Homestead Capital USA Farmland Fund III, L.P. (“Fund III”), with $596 million in capital commitments. With these additional commitments, the firm has surpassed $1 Billion in AUM across its three funds. “We are grateful for the support and opportunity to invest on behalf of our broad range of returning and new investors,” said Dan Little, Co-Founder and Co-CEO of Homestead. “We are humbled by our limited partners’ confidence in us as investors. Fund III represents an endorsement of our ability to drive positive investment outcomes and act as long-term stewards of our limited partners’ capital.” “The United States farmland market continues to undergo a transition that presents many attractive investment opportunities,” said Gabe Santos, also a Co-Founder and Co-CEO of Homestead. “Our strategy is uniquely suited to create value by utilizing o

Bennett Goodman and Avi Kalichstein Launch Hunter Point Capital to Invest in Alternative Investment Managers30.10.2020 21:03:00 EETPress release

Bennett Goodman and Avi Kalichstein today announced the formation of Hunter Point Capital LP (“HPC”), an independent investment firm seeking minority stakes in middle-market alternative asset managers. As part of the launch, HPC has formed a strategic partnership with a group of leading global investment entities associated with Jacob Rothschild. "I am thrilled to initiate this next phase of my career with such an exceptional team. Our HPC partnership seeks to leverage our collective expertise as investors and business builders to cultivate the next generation of outstanding investment franchises,” said Goodman. “Our goal is to help general partners achieve their long-term business objectives faster and with more certainty.” “At our core, Hunter Point Capital is focused on investment excellence. We seek managers with proven track records, who will benefit from a strategic, impact-oriented partner,” said Kalichstein. “There is an expanding universe of high-performing investment manageme

Code:n@xt: PROCAD to Lift the Veil on a New PLM Generation30.10.2020 19:31:00 EETPress release

On November 11, 2020, PRO.FILE next, the next product generation by PROCAD will be officially launched. At 11:00 AM EST, 10:00 AM CET, the groundbreaking, cloud-enabled platform for the digital transformation of business processes will be presented to the public for the first time at Code:n@xt, a must-attend event for anyone interested in digital transformation, information and product lifecycle management. PROCAD's managing directors, strategists, business developers, and developers will come together for Code:n@xt to present PRO.FILE next – whose code will change the world of PLM software. The online event will feature breakout sessions and a live demo of the new system, take a look at today's market demands and digital transformation trends, and give attendees the opportunity to chat with the company's experts. Where does digital transformation start? Where does a PLM platform as a Product Data Backbone fit into it? How do you build an information twin as a digital replica of a piec

INX Applies for Listing on the Canadian Securities Exchange (CSE)30.10.2020 16:00:00 EETPress release

INX Limited (“ INX ”) today announced its application for listing of its digital security, the INX Token, on the Canadian Securities Exchange (“CSE”). The listing application is subject to the approval of the CSE. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20201030005313/en/ Shy Datika, Co-Founder and President at INX (Photo: Business Wire) INX recently launched the first SEC-registered digital security IPO for both retail and institutional investors. INX intends to use the net proceeds from the IPO for a launch of a regulated trading platform for digital assets and provide novel trading and capital raising financial instruments to enterprises in collaboration with traditional exchanges worldwide. The CSE is a proponent of exchange-listed digital securities and continues to work towards additional services in connection with the post-trade processes for these securities. Richard Carleton, CEO of the CSE has stated that “Th

Cognite Collaborates With Microsoft to Transform Industry Through Digitalization and Becomes Global Independent Software Vendor (ISV)30.10.2020 15:44:00 EETPress release

Cognite announced it is working with Microsoft to catalyze the full-scale digital transformation of heavy-asset industries. The Cognite Data Fusion platform, hosted on Microsoft Azure, will deliver industrial data operations and OT/IT data contextualization for hybrid AI development, combining human and Artificial Intelligence to collectively achieve superior results and create faster time to value. This collaboration builds on the common goal to create transformation through digitalization as demonstrated by Microsoft’s recent commitment to The Center for Fourth Industrial Revolution for the Ocean (C4IR), and the Ocean Data Platform (ODP), which is also powered by Cognite technology. ODP is the open and collaborative platform that harnesses the power of data liberation and contextualization connecting data, people and technology for a healthy ocean and is run on Cognite Data Fusion. ODP is a cornerstone of Microsoft’s water sustainability commitment. Both companies are committed to te

In our pressroom you can read all our latest releases, find our press contacts, images, documents and other relevant information about us.

Visit our pressroom